Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, against<i>Trichophyton rubrum</i>involves inhibition of ergosterol biosynthesis

Pereira, Fillipe de Oliveira; Mendes, Juliana Moura; Lima, Igara Oliveira; Mota, Kelly Samara de Lira; Oliveira, Wylly Araújo de; Lima, Edeltrudes de Oliveira

doi:10.3109/13880209.2014.913299

Cited by 111 publications

(72 citation statements)

References 40 publications

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“…origin (Pereira et al 2015;de Oliveira Lima et al 2017). One example of terpenoids is linalool (3,7-dimethyl-1,6octadiene-3-ol), which is a monoterpenic alcohol with diverse biological activity, including antibacterial (Klein et al 2013), anxiolytic (Linck et al 2010), cholesterollowering (Cho et al 2011) and anticonvulsant effects (de Sousa et al 2010).…”

Section: Alternative and New Forms Of Therapymentioning

confidence: 99%

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

2020

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Dermatophytes are the aetiological factors of a majority of superficial fungal infections. What distinguishes them from other pathogenic filamentous fungi is their unique ability to degrade keratin. The remarkable ability of this group of fungi to survive in different ecosystems results from their morphological and ecological diversity as well as high adaptability to changing environmental conditions. Paradoxically, despite the progress in medicine, the prevalence of dermatophyte infections is increasing from year to year. At the beginning of the third millennium, practical diagnostic and therapeutic options are still very limited. This review focuses on understanding the major problems in this aspect of dermatophyte infections and indicates future strategies and perspectives for novel approaches to identification and drugs for elimination of dermatophytes. Particular importance is placed on development of a strategy for a diagnostic pathway and implementation of rapid and reliable diagnostics methods designed by international teams. Furthermore, among compounds that currently arouse great interest, representatives of terpenoids, alkaloids, saponins, flavonoids and essential oils deserve attention. Many of these compounds are undergoing clinical trials as potential antifungal agents, and future research should focus on attempts at determination of the applicability of tested substances. Finally, the advantages and disadvantages in implementation of new diagnostic paths and medicinal substances for routine use are indicated. Journal of Applied Microbiology

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Section: Alternative and New Forms Of Therapymentioning

confidence: 99%

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

2020

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“…It has shown promotion of wound healing, anti‐cancer, anti‐inflammatory, analgesic, and antioxidant benefits . Citronellol has anti‐hypertensive, antifungal, and antibacterial effects . It also acts as an insect repellent.…”

Section: Terpenes (Terpenoids)mentioning

confidence: 99%

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

2018

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There is accumulating evidence for various therapeutic benefits of cannabis/cannabinoids, especially in the treatment of pain, which may also apply to the treatment of migraine and headache. There is also supporting evidence that cannabis may assist in opioid detoxification and weaning, thus making it a potential weapon in battling the opioid epidemic. Cannabis science is a rapidly evolving medical sector and industry with increasingly regulated production standards. Further research is anticipated to optimize breeding of strain-specific synergistic ratios of cannabinoids, terpenes, and other phytochemicals for predictable user effects, characteristics, and improved symptom and disease-targeted therapies.

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“…The tween 80 and the DMSO were solubilized in a proportion that did not exceed 0.5% in the test, and was posteriorly diluted in sterile distilled water in order to reach the initial concentration of 2048µg/mL (HOOD et al, 2003, BRUNI et al, 2004NASCIMENTO et al, 2007;PEREIRA et al, 2014). Furthermore, ketoconazole, fluconazole, itraconazole and miconazole were respectively, purchased from Control Center and Products for Diagnosis (CECON) Ltd. (São Paulo, SP, Brazil).…”

Section: Phytoconstituent Antifungal Standards and Substancesmentioning

confidence: 99%

Study of the antifungal potential of (r)-(+)-citronellal and its association with therapeutic agents used in the treatment of vulvovaginal candidiasis

Medeiros¹,

Silva²,

Pérez³

et al. 2017

Biosci. J.

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ABSTRACT:Vulvovaginal candidiasis (VVC) is a common fungal infection that affects healthy women of all ages. At least 75% of women will develop one or more infections once during their lifetime, with 6 to 9% of those individuals developing recurrent infections. In view of this context, this study sought to evaluate the antifungal potential of the isolated (R)-(+)-citronellal [(R)-(+)-CT] and associated to therapeutic agents of clinical importance. The enantiomer was solubilized in tween 80 and dimethylsulfoxide (DMSO). Posteriorly diluted in sterile distilled water up to the concentration of 2048µg/mL. The minimum inhibitory concentration (MIC) of the product was determined by microdilution in RPMI-1640 obtaining dilutions of 1024-4µg/mL. The minimum fungicidal concentration (MFC) was determined by the Sabouraud dextrose agar (SDA) depletion technique from aliquots of 1µL of the MIC, MIC × 2 and MIC × 4. The MIC and the MFC values of (R)-(+)-CT for 90% of the C. albicans strains were 16 and 32µg/mL respectively. In the susceptibility test, C. albicans presented a high resistance to fluconazole and to itraconazole, 12 (92.30%) of the strains. However, for ketoconazole and miconazole the resistance was of 4 (30.76%) and 3 (23.07%) of the strains respectively. In the combination testing of the (R)-(+)-CT with ketoconazole and miconazole, the resistance was completely reverted. For fluconazole and itraconazole, the resistance was reverted in 9 (75%) and 7 (58.33%) of the strains respectively. The (R)-(+)-CT presented fungicide activity with MFC of MIC × 2. When in combination with ketoconazole, fluconazole, itraconazole and miconazole increased the inhibition zones of these antifungal drugs, reducing the resistance against C. albicans.

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Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, againstTrichophyton rubruminvolves inhibition of ergosterol biosynthesis

Abstract: This study confirms that geraniol and citronellol can be regarded as potential drugs for controlling T. rubrum growth, with great potential against agents of dermatophytosis.

Cited by 111 publications

References 40 publications

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

Study of the antifungal potential of (r)-(+)-citronellal and its association with therapeutic agents used in the treatment of vulvovaginal candidiasis

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