Antifungal Activity of Gentamicin B1 against Systemic Plant Mycoses

Bánfalvi, Gáspár

doi:10.3390/molecules25102401

Cited by 5 publications

(11 citation statements)

References 26 publications

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“…Among all the tested fungal specimens, M. gypseum was highly sensitive to both compounds from C. occidentalis and A. racemosus , followed by M. nanum and T. terestre . When compared to the antifungal activity of antibiotics reported by Banfalvi ( 2020 ), M. gypseum was more susceptible to gentamicin B1 (MIC 3.1 µg/mL). However, evidence shows antifungal topicals are more expensive when used in combination with corticosteroid and less effective as single-agent antifungals (Wheat et al 2017 ).…”

Section: Discussionmentioning

confidence: 69%

In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

2021

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Fungal infections are among the most difficult diseases to manage in humans. Eukaryotic fungal pathogens share many similarities with their host cells, which impairs the development of antifungal compounds. Therefore, it is desirable to harness the pharmaceutical potential of medicinal plants for antifungal drug discovery. In this study, the antifungal activity of sixteen plant extracts was investigated against selected dermatophytic fungi. Of the sixteen plants, the cladode (leaf) of Asparagus racemosus, and seed extract of Cassia occidentalis showed antifungal activity against Microsporum gypseum, Microsporum nanum, Trichophyton mentagrophytes and Trichophyton terrestre. The plant antifungal compounds were located by direct bioassay against Cladosporium herbarum. IR and NMR spectrometry analyses of these compounds identified the presence of saponin (in A. racemosus) and hydroxy anthraquinone (in C. occidentalis) in these antifungal compounds. The antidermatophytic activity of plant anthraquinone and saponins with reports of little or no hemolytic activity, makes these compounds ideal for alternative antifungal therapy and warrants further in-depth investigation in vivo.

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Section: Discussionmentioning

confidence: 69%

In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

2021

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“…Gentamicin is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora purpurea bacteria and is effective against Gram-negative bacterial infections. Major fractions of the gentamicin complex (C1, C1a, C2, C2a) possess weak antifungal activity, but one of the minor components (A, A1-A4, B, B1, X) of gentamicin B1was found to exert strong in vitro antifungal activity against plant pathogenic fungi [25]. The in vitro antifungal activity of aminoglycosides, among them gentamicin major and minor fractions, was detected with gentamycin B1 as the most active minor fraction.…”

Section: Functional Groups Of Aminoglycosides Against Plant Pathogenic Fungimentioning

confidence: 99%

“…The most frequently occurring lethal infec-tion is aspergillosis, especially in neutropenic patients with hematologic malignancy [22]. Disseminated fusariosis is the second most frequent lethal fungal infection [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

“…Major fractions of the gentamicin complex (C1, C1a, C2, C2a) are toxic and possess only moderate antifungal activity. However, among minor gentamicin components (A, A1-A4, B, B1, X), gentamicin B1 was found to be an efficient antifungal agent in vitro, maintaining some of its useful in vivo antifungal potential in mice, either alone or in combination with amphotericin B [25].…”

Section: Introductionmentioning

confidence: 99%

“…Gentamicin B1 is a minor gentamicin component that was reported to be a major nonsense mutation suppressor [25,26]. In addition to gentamicin, the G418 readthrough inducer was reported to counteract the effects of nonsense mutations [26,27].…”

Section: Introductionmentioning

confidence: 99%

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Janus-Faced Molecules against Plant Pathogenic Fungi

Bánfalvi

2021

IJMS

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The high cytotoxicity of the secondary metabolites of mycotoxins is capable of killing microbes and tumour cells alike, similarly to the genotoxic effect characteristic of Janus-faced molecules. The “double-edged sword” effect of several cytotoxins is known, and these agents have, therefore, been utilized only reluctantly against fungal infections. In this review, consideration was given to (a) toxins that could be used against plant and human pathogens, (b) animal models that measure the effect of antifungal agents, (c) known antifungal agents that have been described and efficiently prevent the growth of fungal cells, and (d) the chemical interactions that are characteristic of antifungal agents. The utilization of apoptotic effects against tumour growth by agents that, at the same time, induce mutations may raise ethical issues. Nevertheless, it deserves consideration despite the mutagenic impact of Janus-faced molecules for those patients who suffer from plant pathogenic fungal infections and are older than their fertility age, in the same way that the short-term cytotoxicity of cancer treatment is favoured over the long-term mutagenic effect.

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Apoptotic Janus-faced mycotoxins against thoracal and breast metastases

Bánfalvi

2023

Apoptosis

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Abdominal organs (liver, kidney, spleen) are frequent targets of cancer cell invasion but their primary tumours are less known for their metastatic potential to other organs e.g. to the breast. Despite the known connection of the pathogenesis from breast cancer to liver metastasis, the study of the spread in the opposite direction has been neglected. The notion that breast cancer could be a metastasis besides being a primary tumour is based on rodents’ tumour models upon implantation of tumour cells under the capsule of the kidney or under the Glisson’s capsule of the liver of rats and mice. Tumour cells develop into a primary tumour at the site of subcutaneous implantation. The metastatic process starts with peripheral disruptions of blood vessels near the surface of primary tumours. Tumour cells released into the abdomen cross the apertures of the diaphragm, enter the thoracal lymph nodes and accumulate in parathymic lymph nodes. Abdominal colloidal carbon particles injected into the abdomen faithfully mimicked the migration of tumour cells and deposited in parathymic lymph nodes (PTNs). An explanation is provided why the connection between abdominal tumours and mammary tumours escaped attention, notably, parathymic lymph nodes in humans were referred to as internal mammary or parasternal lymph nodes. The apoptotic effect of Janus-faced cytotoxins is suggested to provide a new approach against the spread of abdominal primary tumours, and metastatic development.

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Antifungal Activity of Gentamicin B1 against Systemic Plant Mycoses

Cited by 5 publications

References 26 publications

In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

Janus-Faced Molecules against Plant Pathogenic Fungi

Apoptotic Janus-faced mycotoxins against thoracal and breast metastases

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