Antifungal activity of bioactive triterpenoid saponin from the seeds of<i>Cassia angustifolia</i>

Khan, Noor Afshan; Srivastava, Ashutosh

doi:10.1080/14786410802625279

Cited by 13 publications

(5 citation statements)

References 11 publications

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“…The current study also showed that C. angustifolia exhibits potential fungicidal property against C. albicans . It was shown earlier that saponins, active ingredients of C. angustifolia, were involved in antifungal activity against Colletotridium dematium [32]. It was reported earlier that a butanol extract of C. angustifolia exhibited antifungal activity against Aspergillus terrus , A. flavus and A. niger [31].…”

Section: Discussionmentioning

confidence: 99%

Pharmacologically active flavonoids from the anticancer, antioxidant and antimicrobial extracts of Cassia angustifolia Vahl

Ahmed

Hayat

Tahir

et al. 2016

BMC Complement Altern Med

171

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Background Cassia angustifolia Vahl. (commonly known as senna makkai or cassia senna), native to Saudi Arabia, Egypt, Yemen and also extensively cultivated in Pakistan, is a medicinal herb used traditionally to cure number of diseases like liver diseases, constipation, typhoid, cholera etc. This study was conducted to evaluate the in-vitro antimicrobial, antioxidant and anticancer assays and phytochemical constituents of aqueous and organic extracts of C. angustifolia leaves.MethodsThe antimicrobial activities of C. angustifolia aqueous and organic (methanol, ethanol, acetone, ethyl acetate) extracts were investigated by the disk diffusion method. These extracts were further evaluated for antioxidant potential by the DPPH radical scavenging assay. Anticancer activities of the extracts were determined by the MTT colorimetric assay. The total phenolic and flavonoid contents of C. angustifolia extracts were evaluated by the Folin-Ciocalteu method and aluminum chloride colorimetric assay, respectively. The structures of the bioactive compounds were elucidated by NMR and ESI-MS spectrometry.ResultsBioactivity-guided screening of C. angustifolia extracts, led to the isolation and identification of three flavonoids quercimeritrin (1), scutellarein (2), and rutin (3) reported for the first time from this plant, showed significant anticancer activity against MCF-7 (IC50, 4.0 μg/μL), HeLa (IC50, 5.45 μg/μL), Hep2 (IC50, 7.28 μg/μL) and low cytotoxicity against HCEC (IC50, 21.09 μg/μL). Significant antioxidant activity was observed with IC50 2.41 μg/mL against DPPH radical. Moreover, C. angustifolia extracts have the potential to inhibit microbial growth of E. cloacae, P. aeruginosa, S. mercescens and S. typhi.Conclusion C. angustifolia extracts revealed the presence of quercimeritrin (1), scutellarein (2), and rutin (3), all known to have useful bioactivities including antimicrobial, antioxidant and anticancer activities.

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Section: Discussionmentioning

confidence: 99%

Pharmacologically active flavonoids from the anticancer, antioxidant and antimicrobial extracts of Cassia angustifolia Vahl

Ahmed

Hayat

Tahir

et al. 2016

BMC Complement Altern Med

171

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“…The laxative effect of this natural product has been linked to its content of anthraquinone glycosides 5. The antifungal activity6 of senna has been demonstrated previously and linked to a triterpenoid glycoside present in the butanolic seed extracts of senna. In addition, a study has demonstrated that an aqueous extract of senna can produce DNA (deoxyribonucleic acid) lesions but cannot induce cytotoxic or mutagenic effects in Escherichia coli cultures; the senna extract has also exhibited an antioxidant/antimutagenic effect in Escherichia coli cultures 7.…”

Section: Introductionmentioning

confidence: 74%

An experimental model to study the effects of a senna extract on the blood constituent labeling and biodistribution of a radiopharmaceutical in rats

Souza

Pereira

Bernardo

et al. 2011

Clinics

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Cassia angustifolia Vahl (senna) is a natural product that contains sennosides, which are active components that affect the intestinal tract and induce diarrhea. Authors have shown that senna produces DNA (deoxyribonucleic acid) lesions in Escherichia coli cultures and can act as an antifungal agent. Natural drugs can alter the labeling of blood constituents with technetium-99m (99mTc) and can affect the biodistribution of radiopharmaceuticals. In this work, we have evaluated the influence of a senna extract on the radiolabeling of blood constituents and on the biodistribution of the radiopharmaceutical sodium pertechnetate (Na99mTcO4) in Wistar rats. Twelve animals were treated with senna extract for 7 days. Blood samples were withdrawn from the animals and the radiolabeling procedure was carried out. The senna extract did not modify the radiolabeling of the blood constituents. A biodistributional assay was performed by administering Na99mTcO4 and determining its activity in different organs and in blood. The senna extract altered the biodistribution of Na99mTcO4 in the thyroid, liver, pancreas, lungs and blood. These results are associated with properties of the chemical substances present in the aqueous senna extract. Although these assays were performed in animals, our findings suggest that caution should be exercised when nuclear medicine examinations using Na99mTcO4 are conducted in patients who are using senna extract.

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“…The flavonoids kaemferol, kaemperin, rhein and isorhamnetin are also present in cassia ( Nair et al, 2002 ). Additionally, butanolic triterpenoid glycoside has been isolated from seeds extracts ( Khan and Srivastava, 2009 ). Various compounds such as nigrin, cathartic acid, Rhamnetin, gluco-sennin, emodin and salicyclic acid are also extracted from cassia ( Sorina et al, 2017 ) and could be used as an alternative medicine to treat the symptoms of COVID-19 ( Biswas et al, 2021 , Khan et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

A comprehensive perspective of traditional Arabic or Islamic medicinal plants as an adjuvant therapy against COVID-19

Ahmed

Jamil

Ismatullah

et al. 2023

Saudi Journal of Biological Sciences

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Antifungal activity of bioactive triterpenoid saponin from the seeds ofCassia angustifolia

Cited by 13 publications

References 11 publications

Pharmacologically active flavonoids from the anticancer, antioxidant and antimicrobial extracts of Cassia angustifolia Vahl

Pharmacologically active flavonoids from the anticancer, antioxidant and antimicrobial extracts of Cassia angustifolia Vahl

An experimental model to study the effects of a senna extract on the blood constituent labeling and biodistribution of a radiopharmaceutical in rats

A comprehensive perspective of traditional Arabic or Islamic medicinal plants as an adjuvant therapy against COVID-19

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