Antifungal activity against anthracnose-causing species of homopterocarpin derivatives

Martinez, Janio; Ramirez, Cesar; González, Jesús Humberto Gil; Quiñones, Winston; Durango, Diego

doi:10.1016/j.heliyon.2023.e13082

Cited by 4 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dissolution, absorption, and binding of curcumin derivatives within the body are closely associated with their bioavailability and distribution. , Due to the formation of hydrogen bonds between hydroxyl groups and water molecules, there was an increase in water solubility. Conversely, the π–π conjugated structure and intramolecular hydrogen bonding resulted in decreased water solubility. − Among them, the C structural framework exhibited an optimal water solubility. Most curcumin derivatives exhibited low BBB permeability and high HIA.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Targeted Screening of Curcumin Derivatives as Pancreatic Lipase Inhibitors Using Computer-Aided Drug Design

Jing,

Luo,

Zeng

et al. 2024

ACS Omega

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…Conversely, the π–π conjugated structure and intramolecular hydrogen bonding resulted in decreased water solubility. 39 − 42 Among them, the C structural framework exhibited an optimal water solubility. Most curcumin derivatives exhibited low BBB permeability and high HIA.…”

Section: Discussionmentioning

confidence: 99%

Targeted Screening of Curcumin Derivatives as Pancreatic Lipase Inhibitors Using Computer-Aided Drug Design

Jing,

Luo,

Zeng

et al. 2024

ACS Omega

View full text Add to dashboard Cite

“…Subsequently, a sterile 6-mm paper disc soaked with the F14 extract was placed on the lid surface. The radial growth of G. boninense was monitored daily for five days, and the resulting data were presented in terms of colony growth (mm) and inhibition (%) compared to the control without extract [15]. The test was conducted in five replicates.…”

Section: Antifungal Assay and Voc Profilingmentioning

confidence: 99%

Antifungal potential of volatiles produced by Aspergillus neoniger F14 against Ganoderma boninense

Lutfia,

Rupaedah,

Hartanto

2024

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

Ganoderma boninense Pat. is a fungal pathogen that primarily afflicts oil palm, leading to decreased palm oil yield and significant economic losses. The recent focus on biocontrol agents producing acids and volatile compounds has gained momentum due to their straightforward synthesis and ease of interaction with the phytopathogen. This research is a component of a project aimed at exploring the local biodiversity of antagonistic fungi in the oil palm plantation environment, with a specific focus on volatile organic compounds (VOCs) detected using Gas Chromatography-Mass Spectrometry (GC-MS). Isolate F14, a collection in the Laboratory of Applied Microbiology, BRIN, Indonesia was identified as Aspergillus neoniger, a novel report as a soil-originating fungal community in Indonesian oil palm plantations. VOC profiling using GC-MS revealed five dominant compounds namely (Z)-9-Tricosene, 1,2,3,4,5-Pentamethylcyclopentane, Dihexyl carbonate, Pentadecane, and Tridecyl laurate. Based on aromatogram disc tests against G. boninense colonies, it was determined that VOCs from A. neoniger F14 inhibited growth by 48% on the fifth day. The findings of this study contribute supportive information for further investigations into VOCs produced by other local antagonistic isolates against G. boninense.

show abstract

“…7 In recent years, despite the development of numerous agricultural techniques to control phytopathogenic fungi, including biological control, utilization of botanical fungicides (such as plant extracts and essential oils), agronomy technology, and the application of ultraviolet light, 8,9 the use of chemical agents known as fungicides remains a predominant choice. 10 The preference for these chemical agents can be justified by their low cost, ease of application, and efficiency compared with other techniques. However, the indiscriminate application of fungicides poses health and environmental risks due to their residual chemical presence in fruits, soil, and water.…”

Section: ■ Introductionmentioning

confidence: 99%

Design and Synthesis of Eugenol Derivatives Bearing a 1,2,3-Triazole Moiety for Papaya Protection against Colletotrichum gloeosporioides

Almeida lima,

Moreira,

Gazolla

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

A series of 19 novel eugenol derivatives containing a 1,2,3-triazole moiety was synthesized via a two-step process, with the key step being a copper(I)-catalyzed azide–alkyne cycloaddition reaction. The compounds were assessed for their antifungal activities against Colletotrichum gloeosporioides, the causative agent of papaya anthracnose. Triazoles 2k, 2m, 2l, and 2n, at 100 ppm, were the most effective, reducing mycelial growth by 88.3, 85.5, 82.4, and 81.4%, respectively. Molecular docking calculations allowed us to elucidate the binding mode of these derivatives in the catalytic pocket of C. gloeosporioides CYP51. The best-docked compounds bind closely to the heme cofactor and within the channel access of the lanosterol (LAN) substrate, with crucial interactions involving residues Tyr102, Ile355, Met485, and Phe486. From such studies, the antifungal activity is likely attributed to the prevention of substrate LAN entry by the 1,2,3-triazole derivatives. The triazoles derived from natural eugenol represent a novel lead in the search for environmentally safe agents for controlling C. gloeosporioides.

show abstract

Antifungal activity against anthracnose-causing species of homopterocarpin derivatives

Cited by 4 publications

References 32 publications

Targeted Screening of Curcumin Derivatives as Pancreatic Lipase Inhibitors Using Computer-Aided Drug Design

Targeted Screening of Curcumin Derivatives as Pancreatic Lipase Inhibitors Using Computer-Aided Drug Design

Antifungal potential of volatiles produced by Aspergillus neoniger F14 against Ganoderma boninense

Design and Synthesis of Eugenol Derivatives Bearing a 1,2,3-Triazole Moiety for Papaya Protection against Colletotrichum gloeosporioides

Contact Info

Product

Resources

About