Antifouling properties of poly(dimethylsiloxane) surfaces modified with quaternized poly(dimethylaminoethyl methacrylate)

Tu, Qin; Wang, Jian-Chun; Li, Rui; He, Juan; Zhang, Yanrong; Shen, Shaofei; Xu, Juan; Li, Jianjun; Yuan, Mao-Sen; Wang, Jinyi

doi:10.1016/j.colsurfb.2012.08.033

Cited by 70 publications

(53 citation statements)

References 46 publications

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“…35 A hydrophilic quaternized poly(dimethylaminoethyl methacrylate) coating for PDMS channels was applied using a surface-initiated atom transfer radical polymerization (SI-ATRP). 36 The coating significantly reduced nonspecific protein adsorption and cell and bacterial adhesion. All of the above the coatings increased the hydrophilicity of the surface to mediate analyte-wall interactions.…”

Section: Fundamentalsmentioning

confidence: 99%

Micro Total Analysis Systems: Fundamental Advances and Biological Applications

et al. 2013

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Section: Fundamentalsmentioning

confidence: 99%

Micro Total Analysis Systems: Fundamental Advances and Biological Applications

et al. 2013

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“…After MPC grafting, the WCA of the surface decreased to 65°. Hydrophilic poly(N-vinylpyrrolidone) (PVP) grafted PDMS elastomer surfaces were fabricated by SI-ATRP for the preparation of anti-biofouling PDMS materials by Wu et al 128 . A new chlorosilane ATRP initiator was synthesized and covalently attached to the hydroxylated PDMS without any pretreatment for surface activation to generate hydroxyl groups on the surface.…”

Section: Pdms Surface Modification Strategiesmentioning

confidence: 99%

Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology

et al. 2017

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In the last decade microfabrication processes including rapid prototyping techniques have advanced rapidly and achieved a fairly mature stage. These advances have encouraged and enabled the use of microfluidic devices by a wider range of users with applications in biological separations and cell and organoid cultures. Accordingly, a significant current challenge in the field is controlling biomolecular interactions at interfaces and the development of novel biomaterials to satisfy the unique needs of the biomedical applications. Poly(dimethylsiloxane) (PDMS) is one of the most widely used materials in the fabrication of microfluidic devices. The popularity of this material is the result of its low cost, simple fabrication allowing rapid prototyping, high optical transparency, and gas permeability. However, a major drawback of PDMS is its hydrophobicity and fast hydrophobic recovery after surface hydrophilization. This results in significant nonspecific adsorption of proteins as well as small hydrophobic molecules such as therapeutic drugs limiting the utility of PDMS in biomedical microfluidic circuitry. Accordingly, here, we focus on recent advances in surface molecular treatments to prevent fouling of PDMS surfaces towards improving its utility and expanding its use cases in biomedical applications.

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“…However, bonding between the SU-8 and PDMS surfaces has proven to be much more difficult [16,17]. Moreover, SU-8/PDMS hybrid microfluidic system is susceptible to channel surface fouling, especially when it is used to handle samples that contain blood, proteins or cells [18]. Therefore, developing a facile method to prepare a SU-8/PDMS heterogeneous microfluidic system with an excellent surface non-fouling performance is important to explore its full potentials in detection and diagnostic applications.…”

Section: Introductionmentioning

confidence: 99%