Antifouling activity of synthesized peptide analogs of the sponge metabolite barettin

Sjögren, Martin; Johnson, A. E.; Hedner, Erik; Dahlström, Mia; Göransson, Ulf; Shirani, Hamid; Bergman, Jan; Jonsson, Per R.; Bohlin, Lars

doi:10.1016/j.peptides.2006.03.027

Cited by 45 publications

(37 citation statements)

References 35 publications

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“…A number of pharmaceuticals and veterinary medicines have been screened for anti-settlement activity [25] and one of these, Medetomidine, is being developed as an anti-foulant [26]. However, pharmaceuticals and veterinary medicines are in general, designed to be stable, both chemically and metabolically—The former to improve the shelf life of the compounds, while the latter to ensure that the drug reaches the desired target(s) for maximal therapeutic effects.…”

Section: Resultsmentioning

confidence: 99%

Searching for “Environmentally-Benign” Antifouling Biocides

Cui

Teo

Leong

et al. 2014

IJMS

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As the result of the ecological impacts from the use of tributyltins (TBT) in shipping, environmental legislation for the registration of chemicals for use in the environment has grown to a monumental challenge requiring product dossiers to include information on the environmental fate and behavior of any chemicals. Specifically, persistence, bioaccumulation and toxicity, collectively known as PBT, are properties of concern in the assessment of chemicals. However, existing measurements of PBT properties are a cumbersome and expensive process, and thus not applied in the early stages of the product discovery and development. Inexpensive methods for preliminary PBT screening would minimize risks arising with the subsequent registration of products. In this article, we evaluated the PBT properties of compounds reported to possess anti-fouling properties using QSAR (quantitative structure-activity relationship) prediction programs such as BIOWIN™ (a biodegradation probability program), KOWWIN™ (log octanol-water partition coefficient calculation program) and ECOSAR™ (Ecological Structure Activity Relationship Programme). The analyses identified some small (Mr < 400) synthetic and natural products as potential candidates for environmentally benign biocides. We aim to demonstrate that while these methods of estimation have limitations, when applied with discretion, they are powerful tools useful in the early stages of research for compound selection for further development as anti-foulants.

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Section: Resultsmentioning

confidence: 99%

Searching for “Environmentally-Benign” Antifouling Biocides

Cui

Teo

Leong

et al. 2014

IJMS

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“…It is worth noting that the most toxic compounds included in this study were the agelasimine analogs AV1217 and AV1213. The structure-activity relationship information available from the screening of the compounds included in this study is limited, but as previously shown, small changes in compounds, for example the position of bromine, have substantial effects on the inhibition of larval settlement (Sjogren et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Antifouling activity of the sponge metabolite agelasine D and synthesised analogs onBalanus improvisus

et al. 2008

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This study reports a screening study for antifouling (AF) activity of the natural compound agelasine D isolated from marine sponges of the genus Agelas and 20 synthesised analogs of agelasines and agelasimines. Agelasine D, together with two of the analogs, ie AV1003A and AKB695, displayed a strong inhibitory effect on settlement of Balanus improvisus cypris larvae. Agelasine D had an EC50 value of 0.11 microM while the two analogs AV1033A and AKB695 had EC50 values of 0.23 and 0.3 microM, respectively. None of these three compounds affected larval mortality as was the case with several of the analogs tested. Moreover, the effect of AV1033A and AKB695 was reversible. When cyprids after 24 h exposure to the compounds were transferred to fresh seawater, the settlement frequency compared with the controls was completely recovered. The properties of the agelasine D analogs AV1003A and AKB695 make them highly attractive candidates as AF agents in future marine coatings.

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“…These include capsaicin and zosteric acid [47][48][49], tannins [18], tannin-aluminium complexes [50] and cupric tannate [51]. Synthetic analogues of naturally occurring antifoulants have also been found to deter fouling [52,53].…”

Section: Natural Antifoulantsmentioning

confidence: 99%

New Directions in Antifouling Technology

Chisholm

2009

Biofouling

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The aim of this chapter is to survey approaches being explored to combat or mitigate fouling, with a primary focus on coating systems. Biocidal coating systems (systems which release biocidal chemicals into the environment) are surveyed, beginning with current self-polishing coatings technology, continuing with new approaches being explored for self-polishing and erodible binder systems, and concluding with a discussion on the use of natural antifoulants and their synthetic analogues as a low-toxicity approach to antifouling. Approaches to non-toxic coating systems are then surveyed beginning with a discussion of the fouling-release concept. Non-toxic coating systems containing bound biocides, hybrid-coating systems, coatings having amphiphilic surfaces and other approaches reported in the literature are also discussed. Many of these new approaches are still in the research stage. By reviewing current research efforts in this field, it is hoped that additional innovative approaches will be stimulated, which can lead to environmentally responsible antifouling coating systems.

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Antifouling activity of synthesized peptide analogs of the sponge metabolite barettin

Cited by 45 publications

References 35 publications

Searching for “Environmentally-Benign” Antifouling Biocides

Searching for “Environmentally-Benign” Antifouling Biocides

Antifouling activity of the sponge metabolite agelasine D and synthesised analogs onBalanus improvisus

New Directions in Antifouling Technology

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