Antifouling Activity of Meroterpenes Isolated from the Ascidian Aplidium aff. densum

Levert, Annabel; Foulon, Valentin; Fauchon, Marilyne; Tapissier‐Bontemps, Nathalie; Banaigs, Bernard; Hellio, Claire

doi:10.1007/s10126-020-10000-9

Cited by 12 publications

(10 citation statements)

References 86 publications

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“…The high-standing genetic variation in OctA gene in B. improvisus could similarly provide the ground for development of medetomidine-tolerant populations. It would therefore be advisable to use multiple strategies with different modes of action, e.g., ivermectin (Pinori et al 2011) or cardiochromene A (Levert et al 2020) in combination with medetomidine, for long-term resilient antifouling control.…”

Section: Discussionmentioning

confidence: 99%

Genomic Characterization of the Barnacle Balanus improvisus Reveals Extreme Nucleotide Diversity in Coding Regions

et al. 2021

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Barnacles are key marine crustaceans in several habitats, and they constitute a common practical problem by causing biofouling on man-made marine constructions and ships. Despite causing considerable ecological and economic impacts, there is a surprising void of basic genomic knowledge, and a barnacle reference genome is lacking. We here set out to characterize the genome of the bay barnacle Balanus improvisus (= Amphibalanus improvisus) based on short-read whole-genome sequencing and experimental genome size estimation. We show both experimentally (DNA staining and flow cytometry) and computationally (k-mer analysis) that B. improvisus has a haploid genome size of ~ 740 Mbp. A pilot genome assembly rendered a total assembly size of ~ 600 Mbp and was highly fragmented with an N50 of only 2.2 kbp. Further assembly-based and assembly-free analyses revealed that the very limited assembly contiguity is due to the B. improvisus genome having an extremely high nucleotide diversity (π) in coding regions (average π ≈ 5% and average π in fourfold degenerate sites ≈ 20%), and an overall high repeat content (at least 40%). We also report on high variation in the α-octopamine receptor OctA (average π = 3.6%), which might increase the risk that barnacle populations evolve resistance toward antifouling agents. The genomic features described here can help in planning for a future high-quality reference genome, which is urgently needed to properly explore and understand proteins of interest in barnacle biology and marine biotechnology and for developing better antifouling strategies.

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Section: Discussionmentioning

confidence: 99%

Genomic Characterization of the Barnacle Balanus improvisus Reveals Extreme Nucleotide Diversity in Coding Regions

et al. 2021

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“…For example, effective antifoulants against barnacles and microfoulants (Oguri et al 2017) have been found in the red alga Laurencia sp. (Oguri et al 2017), tunicates (Levert et al 2020), the mollusk Phidiana militaris (Levert et al 2020), holothurians (Kamyab et al 2020), and sponges (Tintillier et al 2020). Antifoulants may improve the success of marine invasive tunicates (Utermann et al 2020;Nagai et al 2021).…”

Section: Chemical Defensementioning

confidence: 99%

Chemical cues for intraspecific chemical communication and interspecific interactions in aquatic environments: applications for fisheries and aquaculture

2021

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Aquatic organisms detect chemical cues to sense the local environment, for example, to find a mate, locate food, and identify danger. Knowledge of chemical cues can be used in aquaculture, in practical applications such as controlling mating behavior to increase fertility, enhance feeding, and decrease stress; in fisheries, by catching selected species with low-cost artificial attractants; and to address maritime issues, by decreasing biofouling. Aquatic organisms also detect chemical cues related to global environmental changes, ocean acidification, and increases in ocean plastics, all of which can affect their chemosensory behaviors. Here we discuss the nature of chemical cues and chemosensory biology and ecology of aquatic organisms, and potential applications with an emphasis on sex pheromones in commercially important and well-studied animals, namely, decapod crustaceans and fish.

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“…Thus, it is important to carefully think about the desired mode of action and, if necessary, to work on the development of innovative methods to evaluate the activity. Within the framework of the development of new antifouling solutions that are eco-friendly and in order to avoid secondary effects on non-target organisms as much as possible, the biological activity sought is not a biocidal activity (as it was usually done) but an adhesion-inhibitory or deterrent activity [2,[21][22][23][24][25]. This approach is also interesting in the context of marketing authorization applications.…”

Section: Evaluation Of Antifouling Activitymentioning

confidence: 99%

“…Thus, secondary metabolites with significant levels of anti-epibiosis activity have been isolated and could be incorporated in antifouling paints [17][18][19][20]. These molecules have the advantage of exhibiting targeted activities and acting at very low concentrations, and thus their use in paint compositions is promising from this point of view [2,[21][22][23][24][25]. The ideal solution would be to use natural products to prevent the settlement of fouling organisms rather than inhibiting their growth [2,[21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

“…These molecules have the advantage of exhibiting targeted activities and acting at very low concentrations, and thus their use in paint compositions is promising from this point of view [2,[21][22][23][24][25]. The ideal solution would be to use natural products to prevent the settlement of fouling organisms rather than inhibiting their growth [2,[21][22][23][24][25]. Settlement inhibitors are not considered as biocides, and thus regulations for their market authorization are less restrictive, allowing for faster development and deployment.…”

Section: Introductionmentioning

confidence: 99%

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Antifouling Activity of Halogenated Compounds Derived from the Red Alga Sphaerococcus coronopifolius: Potential for the Development of Environmentally Friendly Solutions

et al. 2021

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Nowadays, biofouling is responsible for enormous economic losses in the maritime sector, and its treatment with conventional antifouling paints is causing significant problems to the environment. Biomimetism and green chemistry approaches are very promising research strategies for the discovery of new antifouling compounds. This study focused on the red alga Sphaerococcus coronopifolius, which is known as a producer of bioactive secondary metabolites. Fifteen compounds, including bromosphaerol (1), were tested against key marine biofoulers (five marine bacteria and three microalgae) and two enzymes associated with the adhesion process in macroalgae and invertebrates. Each metabolite presented antifouling activity against at least one organism/enzyme. This investigation also revealed that two compounds, sphaerococcinol A (4) and 14R-hydroxy-13,14-dihydro-sphaerococcinol A (5), were the most potent compounds without toxicity towards oyster larvae used as non-target organisms. These compounds are of high potential as they are active towards key biofoulers and could be produced by a cultivable alga, a fact that is important from the green chemistry point of view.

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Antifouling Activity of Meroterpenes Isolated from the Ascidian Aplidium aff. densum

Cited by 12 publications

References 86 publications

Genomic Characterization of the Barnacle Balanus improvisus Reveals Extreme Nucleotide Diversity in Coding Regions

Genomic Characterization of the Barnacle Balanus improvisus Reveals Extreme Nucleotide Diversity in Coding Regions

Chemical cues for intraspecific chemical communication and interspecific interactions in aquatic environments: applications for fisheries and aquaculture

Antifouling Activity of Halogenated Compounds Derived from the Red Alga Sphaerococcus coronopifolius: Potential for the Development of Environmentally Friendly Solutions

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