Antifibrotic Effect of Boric Acid in Rats with Epidural Fibrosis

Bozkurt, Hüseyin; Bektaşoğlu, Pınar Kuru; Börekci, Ali; Öztürk, Özden Çağlar; Kertmen, Hayri; Eğılmez, Reyhan; Yuce, Mehmet Fatih; Gürer, Bora

doi:10.1016/j.wneu.2018.10.187

Cited by 8 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the study conducted by H. Bozkurt et al, it was demonstrated that the antifibrotic effect of 5% boric acid could reduce epidural fibrosis. [16] This study aimed to reduce intra-abdominal adhesions, whose basic formation mechanisms include inflammation and fibrosis, through a similar mechanism.…”

Section: Discussionmentioning

confidence: 99%

Effect of intra-abdominal boric acid in the experimental adhesion model

Kabalar

2024

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

BACKGROUND:The continuous advancement in medical and surgical techniques has led to a rise in the frequency of abdominal operations, subsequently increasing the incidence of intra-abdominal adhesions. Over 90% of laparotomies result in postoperative intra-abdominal adhesions. This study investigates the effect of a 5% boric acid solution on the development of intra-abdominal adhesions in rats, using an adhesion model. METHODS:This study was conducted with two groups: a control group, in which the adhesion model was applied without any treatment, and a boric acid group, which was treated with a 5% boric acid solution. Each group comprised 16 rats. On the 14th postoperative day, the rats were sacrificed, re-explored, and the developed adhesions were evaluated both macroscopically and microscopically. The data from macroscopic and microscopic scoring were analyzed using the Mann-Whitney U test in the IBM Statistical Package for the Social Sciences (SPSS) Statistics 24 program. A p-value of less than 0.05 was considered statistically significant. This research was supported by the Manisa Celal Bayar University Scientific Research Projects Commission. RESULTS:A statistically significant difference was observed between the boric acid-treated group and the control group, with the boric acid group showing a significant decrease in adhesion development both macroscopically and microscopically (p<0.05). CONCLUSION:In the future, boron could play a significant role in reducing and preventing intra-abdominal adhesions after surgery. This investigation could pave the way for further research into the mechanism by which boric acid prevents the development of intra-abdominal adhesions. Moreover, it is imperative to explore the potential side effects of intra-abdominal boron application at the optimum concentration of the solution.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of intra-abdominal boric acid in the experimental adhesion model

Kabalar

2024

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

show abstract

“…Laminectomy is a surgical procedure typically employed in the treatment of numerous spinal disorders such as lumbar disk herniation, spinal stenosis, and tumor excision [ 1 ]. Although this treatment is generally effective and relieves neural compression, 8–40% of patients suffer from failed back surgery syndrome (FBSS), with 4–9% undergoing revision surgery [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Antifibrotic Effect of Bletilla striata Polysaccharide-Resveratrol-Impregnated Dual-Layer Carboxymethyl Cellulose-Based Sponge for The Prevention of Epidural Fibrosis after Laminectomy

et al. 2021

View full text Add to dashboard Cite

The application of antifibrotic materials can alleviate epidural fibrosis by restricting excessive fibroblast proliferation and mitigating scar tissue formation. Here, a biodegradable carboxymethyl cellulose (CMC)-Bletilla striata polysaccharide (BSP)-resveratrol (RES) sponge was fabricated to inhibit scar tissue formation post laminectomy surgery. Fibroblasts NIH/3T3, myoblasts C2C12, neural cells PC-12, and Schwann cells RSC96 were used to evaluate the in vitro cytocompatibility. Laminectomies on 10 Sprague–Dawley rats with/without the application of the CMC-BSP-RES sponge were performed. The severity of adhesion between the dura mater and formed scar tissue was qualitatively scored. All cell lines exhibited good viability with no significant difference in cytotoxicity when cultured with variable extractions of the CMC-BSP-RES sponge. S100a4 and P4hb expressions were downregulated in NIH/3T3 cultured in the CMC-BSP-RES sponge, implying that this sponge potentially inhibits fibroblast activity. No post-operative shrinkage or dura mater expansion along the surgical site was detected. The peel-off tests revealed that the tenacity of adhesion de-creased. Histopathological examinations verified that the average number of fibroblasts in the CMC-BSP-RES group considerably decreased. The CMC-BSP-RES sponge is a biocompatible and effective material for alleviating post-operative epidural fibrosis and mitigating fibroblast expression following laminectomy.

show abstract

“…The oxidative damage impaired endothelium-dependent vasodilatation and endothelial cell growth, causing apoptosis, stimulating endothelial cell migration, and activating adhesion molecules, finally leading to tissue adhesion and scar tissue formation. 25,26 Decreasing the oxidative stress has been proved to inhibit the epidural fibrosis and adhesion formation. 27,28 There are various antiadhesion barriers with the ability to regulate oxidative stress.…”

mentioning

confidence: 99%

“…An accumulation of reactive oxygen species (ROS) after tissue injury contributes to vascular dysfunction and remodeling through oxidative damage. The oxidative damage impaired endothelium-dependent vasodilatation and endothelial cell growth, causing apoptosis, stimulating endothelial cell migration, and activating adhesion molecules, finally leading to tissue adhesion and scar tissue formation. , Decreasing the oxidative stress has been proved to inhibit the epidural fibrosis and adhesion formation. , There are various antiadhesion barriers with the ability to regulate oxidative stress . Wang et al developed a multifunctional supramolecular hydrogel with antioxidant properties for epidural adhesion prevention.…”

mentioning

confidence: 99%

Organism-Inspired Antioxidant Bioadhesive with Strong Sealing Ability to Prevent Epidural Adhesion

Gong,

Zhu,

Chen

et al. 2024

ACS Nano

View full text Add to dashboard Cite

Epidural adhesion or epidural fibrosis is the major reason for postoperative pain, which remains a clinically challenging problem. Current physical barriers fail to provide a satisfactory therapeutic outcome mainly due to their lack of adhesion, inability to prevent fluid leakage, and exhibiting limited antioxidant properties. Herein, we fabricated a cysteine-modified bioadhesive (SECAgel) with improved sealing and antioxidant properties for epidural adhesion prevention, inspired by the organism's antioxidant systems. The resulting SECAgel showed good injectability and in situ adhesion ability, effectively covering every corner of the irregular wound. Besides, it possessed efficient sealing properties (395.2 mmHg), effectively stopping blood leakage in the rabbit carotid artery transection model. The antioxidant experiments demonstrated that the SECAgel effectively scavenged various radicals and saved the cells from oxidative stress. Two animal models were used to show that the SECAgel effectively inhibited adhesion in both situations with and without cerebrospinal fluid leakage. The RNA sequencing analysis showed that SECAgel treatment effectively inhibited the expression of key genes related to adhesion development, inflammatory response, and oxidative stress. The SECAgel, together with good biocompatibility, can be a good candidate for preventing epidural adhesion in the clinic.

show abstract

Antifibrotic Effect of Boric Acid in Rats with Epidural Fibrosis

Cited by 8 publications

References 31 publications

Effect of intra-abdominal boric acid in the experimental adhesion model

Effect of intra-abdominal boric acid in the experimental adhesion model

Antifibrotic Effect of Bletilla striata Polysaccharide-Resveratrol-Impregnated Dual-Layer Carboxymethyl Cellulose-Based Sponge for The Prevention of Epidural Fibrosis after Laminectomy

Organism-Inspired Antioxidant Bioadhesive with Strong Sealing Ability to Prevent Epidural Adhesion

Contact Info

Product

Resources

About