Antifertility effects of EP‐1 (quinestrol and levonorgestrel) on Pacific rats (<i>Rattus exulans</i>)

LIU, Jing; TU, Feiyun; LIU, Ming; WANG, Jichao; ZHANG, Zhibin

doi:10.1111/1749-4877.12774

Cited by 2 publications

(2 citation statements)

References 45 publications

(121 reference statements)

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“…Research on these steroids for rodent fertility control was pioneered in China by Professor Zhibin Zhang (host of the 1st ICRBM in Beijing) (see recent review by Jacoblinnert et al 2022b) and has led to research on EP-1 in other rodent species in Africa, Indonesia, and South Asia. In this volume, Liu et al (2023a) showed that the effects of EP-1 on the Pacific rat, Rattus exulans, were greatest in males, but that the dose and palatability of food baits containing the steroids require further development before field studies on islands would be feasible. Liu J. et al's results reflect the need to directly assess the response of a species to a control agent that has been tested in several other species (Jacoblinnert et al 2022;Massei et al 2023).…”

Section: Fertility Controlmentioning

confidence: 99%

“…In this volume, Liu et al. (2023a) showed that the effects of EP‐1 on the Pacific rat, Rattus exulans , were greatest in males, but that the dose and palatability of food baits containing the steroids require further development before field studies on islands would be feasible. Liu J. et al.’ s results reflect the need to directly assess the response of a species to a control agent that has been tested in several other species (Jacoblinnert et al.…”

Section: Re‐emergence Of Interest In Fertility Controlmentioning

confidence: 99%

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Rodent biology and ecologically based rodent management (EBRM)—25 years of progress through promoting multidisciplinary research

SINGLETON,

HINDS,

MAKUNDI

et al. 2023

Integr. Zool.

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Rodent biology and ecologically based rodent management (EBRM)-25 years of progress through promoting multidisciplinary research"During rodent outbreak years in eastern Africa, locally, more than 80% of the potential harvest may be lost, but even in non-outbreak periods, rodents cause chronic damage to crops…. The pest rodent story in Africa involves several species embedded in a broad and variable landscape with highly variable densities." (Leirs et al. 2010).Rodents make up approximately 42% of mammalian species and their domestication has provided many scholarly and health benefits (Singleton & Krebs 2007). However, rodents are better known as frightful pests, a scourge of human populations. Their presence in urban, rural, and natural environments causes major negative economic, social, health, and biodiversity impacts. Interestingly, less than 10% of rodent species are involved in these negative impacts at a global scale ) and less than 5% of rodent species in Africa (Makundi et al. 1999). Nevertheless, the impacts are of major concern to both smallholder farmers in developing countries (Leirs 2002;Massawe et al. 2011;Singleton et al. 2021) and broadscale farmers in developed countries (Brown 2007), and the effects on health and food security are concerning (Meerburg et al. 2009a,b).The quote above together with the broad framework of impacts of rodents provide an apposite framework for this special issue of papers from the 7th International Conference on Rodent Biology and Management (ICRBM) that was held in July 2022 in Arusha, Tanzania. The conference was hosted by the

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Section: Fertility Controlmentioning

confidence: 99%

Section: Re‐emergence Of Interest In Fertility Controlmentioning

confidence: 99%

Rodent biology and ecologically based rodent management (EBRM)—25 years of progress through promoting multidisciplinary research

SINGLETON,

HINDS,

MAKUNDI

et al. 2023

Integr. Zool.

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The impact of clarithromycin, a CYP3A4 inhibitor, on quinestrol inhibition of male mice reproduction

Ji,

Wang,

Liu

et al. 2024

Preprint

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Pest rodents persistently undermine crop yields and food security. Fertility control could be a viable alternative for managing rodent populations. This study investigates the antifertility effects of various concentrations of clarithromycin combined with 1.0 mg/kg quinestrol on male rodents to determine an effective contraceptive dose that minimizes quinestrol usage, addressing concerns such as environmental residue and poor palatability. Male mice were divided into five groups and administered different doses of clarithromycin or clarithromycin and quinestrol for three consecutive days, while the control group received sunflower seed oil only. After seven days, organ weights, reproductive organ weights, sperm density, serum hormone levels, CYP3A4, and proteins in the liver and small intestine were measured to assess persistent effects. Compared with the control group, all treatment groups had significant reductions in epididymal weight, seminal vesicle weight, and serum T levels. Quinestrol, alone or combined with clarithromycin, increased liver and spleen weight. Co-administration of clarithromycin further reduced sperm density and serum LH levels compared to quinestrol alone. The combination of 2.0 mg/kg clarithromycin and quinestrol mitigates issues such as organ enlargement caused by quinestrol alone. Moreover, it reduces the elevation in total enzyme content, diminishing quinestrol's induction of the CYP3A4 enzyme, enhancing the sterilizing effectiveness and efficiency of rodent population control.

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Antifertility effects of EP‐1 (quinestrol and levonorgestrel) on Pacific rats (Rattus exulans)

Cited by 2 publications

References 45 publications

Rodent biology and ecologically based rodent management (EBRM)—25 years of progress through promoting multidisciplinary research

Rodent biology and ecologically based rodent management (EBRM)—25 years of progress through promoting multidisciplinary research

The impact of clarithromycin, a CYP3A4 inhibitor, on quinestrol inhibition of male mice reproduction

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