Antifertility effect of gossypol in male Japanese quail

Lin, Yi‐Chia; Dietrick, Tim; Rikihisa, Yasuko; Beane, W. L.

doi:10.1016/0024-3205(88)90381-5

Cited by 7 publications

(4 citation statements)

References 33 publications

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“…Surprisingly, replacing soybean meal with CSM had a positive effect on sperm motility in catfish. This would be in major contrast to mammals, in which gossypol administered orally inhibited the fertility of male rats [9,10], birds [11], and humans [12]. Spermicidal effects were also demonstrated in vitro on human, monkey, and mouse spermatozoa.…”

Section: Introductionmentioning

confidence: 63%

Effects of Diets Containing Gossypol on Reproductive Capacity of Rainbow Trout (Oncorhynchus mykiss)1

Dąbrowski

Rinchard

Lee

et al. 2000

Biology of Reproduction

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We evaluated five practical diets in which 0%, 25%, 50%, 75%, and 100% (dietary treatments 1-5) of fish meal protein was replaced by solvent-extracted cottonseed meal protein. Adult rainbow trout (initial average weight 247 +/- 8 g) were fed the diets over a period of 131 days during which a general 2-fold body weight increase occurred. The total diet gossypol concentration (free and protein-bound) showed a gradual increase with increased cottonseed meal substitution. Blood samples were collected on Days 0, 64, 112, and 131 for hematological and steroid hormone determination in plasma of males and females. Hemoglobin content was significantly reduced in fish from treatment 5 (7.9 +/- 0.3 g/dl) in comparison to treatments 1-3 (10.3-10.9 g/dl). After 112 and 131 days of feeding, testis weights, concentrations of testosterone, and 11-ketotestosterone were elevated in fish from dietary treatments 2 and 3 in comparison to control and diets 4 and 5. On Day 71, sperm were collected from 6 fish per dietary treatment to assess sperm quality. No significant differences in sperm concentrations (7.2-9.8 x 10(9)/ml), motility (78-89%), and standardized (300 x 10(5) sperm/egg) fertilizing ability (18.9-22.6% hatched embryos) were found. Total gossypol concentrations in blood plasma differed significantly among treatments, and the levels were among the highest ever recorded in animals fed cottonseed-supplemented diets (2.9 +/- 0.2, 11.7 +/- 4.1, 21.7 +/- 1.4, and 29.9 +/- 3.9 microg/ml, for treatments 2-5, respectively). The major portion of gossypol in blood plasma was protein-bound (81-93%). This was in contrast to minute amounts of gossypol present in seminal plasma, mostly in free form (0.02-0.18 microg/ml), which indicates the presence of a barrier between general circulation and the testis with respect to gossypol distribution in lower vertebrates. Thus, the reproductive parameters of male rainbow trout examined in this study were not significantly affected by feeding cottonseed meal for 131 days.

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Section: Introductionmentioning

confidence: 63%

Effects of Diets Containing Gossypol on Reproductive Capacity of Rainbow Trout (Oncorhynchus mykiss)1

Dąbrowski

Rinchard

Lee

et al. 2000

Biology of Reproduction

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“…Cottonseed meal contains gossypol, a phenolic chemical compound that is found in the pigment glands of the cotton plant. Gossypol is not only toxic to fish but has also been reported to interfere with physiological processes of reproduction, including inhibition of steroidogenesis in animals (Hadley, Lin & Dym 1981; Coutinho, Segal, Melo & Barbosa 1985; Lin, Dietrick & Rikihisa 1988). Salaro, Pezzato, Barros and Vicentini (1999) observed lowered number of spermatozoa in the testis lumen when O. niloticus was fed on diets containing 24% CSM.…”

Section: Discussionmentioning

confidence: 99%

Growth and economic performance of Nile tilapia (Oreochromis niloticus L.) fed on two formulated diets and two locally available feeds in fertilized ponds

et al. 2005

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Lack of suitable diets for semi‐intensive production of Oreochromis niloticus in Kenya has necessitated use of expensive diets designed for intensive production. To address this problem, two isonitrogenous (24% protein) diets were formulated and evaluated for production of O. niloticus in fertilized ponds. One diet contained vitamins and minerals premix (CV) while the other had no premix (CW). Growth of fish fed on the formulated feeds was compared with groups of fish fed on commercial pig pellets (PP) and wheat bran (WB). There were significant differences in mean weights, growth rates and feed conversion ratios between the formulated and the other diets. No significant differences in these parameters were observed between CV and CW and also between PP and WB. Fish that fed on the formulated feeds produced significantly lower number of juveniles than those fed on PP and WB. Fish fed on WB gave the best economic returns while those on PP had the least returns. Present results suggest that vitamins and minerals premix may not be necessary in diets for semi‐intensive production of O. niloticus. Present results showed that the formulated feeds produced higher yields than PP and WB, but WB had the best economic returns among the test diets.

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“…Based on several previous studies, the toxic effects of gossypol on male reproductive performance have varied among species [ 9 ], such as enhancing sperm abnormalities in bulls [ 10 ], reducing sperm count and motility in rats [ 11 ], and increasing spermatocyte degeneration in hamsters [ 12 ]. Such toxicities also show dose-dependent, time-dependent, and even reversible characteristics [ 10 , 13 , 14 ]. Studies in avian species also supported the unique reversible characteristics of gossypol toxicity in a species-specific manner.…”

Section: Introductionmentioning

confidence: 99%

“…For example, domestic cocks fed with an effective dose of gossypol at 40 mg/kg body weight (BW) per day for 18 days had a full recovery of semen quality within 4 weeks after cessation of gossypol treatment [ 15 ]. In Japanese quail, the supplement gossypol at a dose of 25 mg/kg BW per day for 12 and 24 days resulted in severe infertility of the birds by which their complete recovery could be acquired after 11 and 20 days of gossypol withdrawal, respectively [ 14 ]. Due to the species-dependent characteristics of gossypol, its dose-dependent and time-dependent effects require separate investigation whenever applied to a novel bird species.…”

Section: Introductionmentioning

confidence: 99%

The reversible effects of gossypol toxicity on male pigeons' reproductive performance

et al. 2022

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Background and Aim: Gossypol, a cotton seed derivative, is well known for its reversible antifertility in male reproduction across species. Its antifertility and reversibility effects on male reproductive function vary among species in dose-and time-dependent manners. In this study, the antifertility potential of gossypol in pigeons was evaluated for the first time to determine whether it might be used as a dietary supplement for pigeon population control. Materials and Methods: Male pigeons were assigned into three experimental groups: The gossypol-treated group (n = 12), the sham control group (n = 6), and the negative control group (n = 6). There were two experimental periods: A gossypol-feeding period of 28 days and a gossypol-free period of 28 days. During the gossypol-feeding period, birds in the gossypol-treated group were fed 4 mg of gossypol extract per day. Birds in the sham control group were fed 0.5 mL of mixed ethanol and sunflower oil, while those in the negative control group were fed 0.5 mL of phosphate buffer saline. After the gossypol-feeding phase was completed, all remaining pigeons in all groups continued to receive their regular diet for an additional 28 days (gossypol-free phase). The body weight and semen quality of the birds in the experimental groups were compared to evaluate gossypol's antifertility effect. Results: In the gossypol-treated group as compared to the control groups, the percentages of sperm motility and viability were significantly lower at 21 days, and the percentage of normal sperm morphology was significantly lower at 28 days during the gossypol-feeding period. After gossypol withdrawal, these antifertility effects were resumed and reached a comparable semen quality to the control groups within 14 days. Conclusion: Gossypol supplementation (4 mg/day for 28 days) could lower male pigeons' reproductive performance in terms of sperm motility, viability, and sperm morphology. Such infertility was, however, reversible within 14 days after gossypol withdrawal without any side effects on the pigeons, suggesting its application as a safe contraceptive feeding for male pigeons.

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Antifertility effect of gossypol in male Japanese quail

Cited by 7 publications

References 33 publications

Effects of Diets Containing Gossypol on Reproductive Capacity of Rainbow Trout (Oncorhynchus mykiss)1

Effects of Diets Containing Gossypol on Reproductive Capacity of Rainbow Trout (Oncorhynchus mykiss)1

Growth and economic performance of Nile tilapia (Oreochromis niloticus L.) fed on two formulated diets and two locally available feeds in fertilized ponds

The reversible effects of gossypol toxicity on male pigeons' reproductive performance

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