Antifertility effect of calcium channel blockers on male rats: association with oxidative stress

Morakinyo, Ayodele Olufemi; Iranloye, Bolanle; Daramola, A O; Adegoke, OA

doi:10.2478/v10039-011-0018-y

Cited by 32 publications

(23 citation statements)

References 57 publications

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“…Oxidative analyses of part of the serum were carried out using previously described standard methods [25]. Briefly, the activity of the superoxide dismutase (SOD) enzyme was determined according to the method described by Sun and Zigman [26].…”

Section: Assessment Of Antioxidant Enzymes Level and Lipid Peroxidationmentioning

confidence: 99%

Protective but Non-Synergistic Effects of Nigella Sativa and Vitamin E against Cisplatin-Induced Renal Toxicity and Oxidative Stress in Wistar Rats

Busari¹,

Adejare

Shodipe³

et al. 2018

Drug Res (Stuttg)

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Section: Assessment Of Antioxidant Enzymes Level and Lipid Peroxidationmentioning

confidence: 99%

Protective but Non-Synergistic Effects of Nigella Sativa and Vitamin E against Cisplatin-Induced Renal Toxicity and Oxidative Stress in Wistar Rats

Busari¹,

Adejare

Shodipe³

et al. 2018

Drug Res (Stuttg)

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“…Thus, ROS contribute to angiogenic signalling [6]. The negative ROS effects consist in the contribution to the disease pathology and complication [7]. After implantation, the skeletal muscles surrounding the biomaterials are affected by different particle sizes and morphologies.…”

Section: Introductionmentioning

confidence: 99%

Biological therapy of strontium-substituted bioglass for soft tissue wound-healing: Responses to oxidative stress in ovariectomised rats

Jebahi

Oudadesse

Jardak

et al. 2013

Annales Pharmaceutiques Françaises

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“…Single-nucleotide polymorphisms in AKR1C3 have been associated with disease progression and aggressiveness in prostate carcinomas (Izumoto et al , 2005; Richards et al , 2006). AKR1C3 polymorphisms have also been shown to modulate the risk of other cancers, including bladder cancer, childhood leukaemias and diffuse large B-cell lymphoma (Bauman et al , 2004; Morakinyo et al , 2011; Adegoke et al , 2012c). Separately, it has been shown that AKR1C3 can inactivate and induce resistance to the anticancer drugs doxorubicin, oracin and cisplatin (Adegoke and Nyokong, 2012; Adegoke et al , 2012a, 2012b), whereas elevated AKR1C3 protein levels were associated with radioresistance in non-small cell lung carcinomas (Jamieson et al , 2012).…”

mentioning

confidence: 99%

Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate

et al. 2014

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Background:We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer and leukaemia. As a consequence, significant effort is being invested in the development of AKR1C3-selective inhibitors.Methods:We report the screening of an in-house drug library to identify known drugs that selectively inhibit AKR1C3 over the closely related isoforms AKR1C1, 1C2 and 1C4. This screen initially identified tetracycline as a potential AKR1C3-selective inhibitor. However, mass spectrometry and nuclear magnetic resonance studies identified that the active agent was a novel breakdown product (4-methyl(de-dimethylamine)-tetracycline (4-MDDT)).Results:We demonstrate that, although 4-MDDT enters AML cells and inhibits their AKR1C3 activity, it does not recapitulate the anti-leukaemic actions of the pan-AKR1C inhibitor medroxyprogesterone acetate (MPA). Screens of the NCI diversity set and an independently curated small-molecule library identified several additional AKR1C3-selective inhibitors, none of which had the expected anti-leukaemic activity. However, a pan AKR1C, also identified in the NCI diversity set faithfully recapitulated the actions of MPA.Conclusions:In summary, we have identified a novel tetracycline-derived product that provides an excellent lead structure with proven drug-like qualities for the development of AKR1C3 inhibitors. However, our findings suggest that, at least in leukaemia, selective inhibition of AKR1C3 is insufficient to elicit an anticancer effect and that multiple AKR1C inhibition may be required.

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Antifertility effect of calcium channel blockers on male rats: association with oxidative stress

Cited by 32 publications

References 57 publications

Protective but Non-Synergistic Effects of Nigella Sativa and Vitamin E against Cisplatin-Induced Renal Toxicity and Oxidative Stress in Wistar Rats

Protective but Non-Synergistic Effects of Nigella Sativa and Vitamin E against Cisplatin-Induced Renal Toxicity and Oxidative Stress in Wistar Rats

Biological therapy of strontium-substituted bioglass for soft tissue wound-healing: Responses to oxidative stress in ovariectomised rats

Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate

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