Antifertility activity of volatile fraction of neem oil

Potential antifertility agents from plants: A comprehensive review

“…Literature survey of the cited plants confirmed that Abrus precatorius (Ross, 2005;Okoko et al, 2010), Acalypha indica (Hafez, 1970;Shivayogi et al, 1999), Ailanthus excelsa (Ravichandran et al, 2007), Ananas comosus (Bhaduri et al, 1968;Garó et al, 1970;Näf-Müller and Willhalm, 1971), Aristolochia bracteolata (Natraj et al, 2007), Azadirachta indica (Riar et al, 1991;Sinha et al, 1984a,b), Bambusa vulgaris (Yakubu and Bukoye, 2009), Embelia ribes (Radhakrishnan and Alam, 1975;Garg and Garg, 1978;Prakash, 1981), Hibiscus rosa-sinensis (Pakrashi et al, 1986;Vasudeva and Sharma, 2008), Plumbago zeylanica (Premakumari et al, 1977;Chowdhury et al, 1982;Edwin et al, 2009), Vicoa indica (Dhall and Dogra, 1988;Rao et al, 1996) potent antifertility effects.…”

“…Neem tree is reported as antiviral (Gogati and Marathe, 1989), antibacterial (Singh andSastry, 1997), hypolipidaemic (Purohit andDaradka, 1999), anti-inflammatory, antipyretic (Okpanyi and Ezeukwu, 1981), antiseptic, antiparalitic (Allan et al, 1991) and antioxidant agents. Along with leaves, bark, seeds, NIM-76, a volatile fraction from neem oil is reported to have post-coital antifertility activity in rats, rabbits and monkeys (Riar et al, 1991). In another study, intrauterine application of neem oil caused a pre-implantation block in fertility (Upadhay et al, 1990).…”

Essential oils rich in monoterpenes are unsuitable as additives to boar semen extender

“…Malo, Gil, Cano, Martinez, and Gale (2011) showed that the addition of rosemary EO to freezing extender improved the post-thaw quality of epididymal spermatozoa, showing a significant correlation between rosemary concentration and lipoperoxidation. (Meliaceae) (Riar et al, 1991), Phytolacca dodecandra Hérit. Differently, other studies have shown that some plants have spermicidal activity such as Azadirachta indica A. Juss.…”

Azadirachta indica

“…Intravaginal application of NIM-76 in rabbits showed no irritation to the vaginal mucosa. NIM-76 was found to have antifertility effects in rats, rabbits and rhesus monkeys when applied before coitus but not so when applied during post-coital stages (Riar et al 1991 ). Thus, it appeared to act mainly by its spermicidal effect.…”