Antifertility Activity and Toxicity of a-Chlorohydrin Aromatic Ketal Analogues in Male Rats

Brown‐Woodman, P. D. C.; White, I. G.; Ridley, Damon D.

doi:10.1071/bi9860187

Cited by 5 publications

References 11 publications

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3‐Chlor‐1,2‐propandiol [MAK Value Documentation in German language, 1992]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 18. Lieferung, Ausgabe 1992 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Angaben zur Pharmakokinetik Erfahrungen beim Menschen Tierexperimentelle Befunde Akute Toxizität Subchronische und chronische Toxizität In vivo ‐Untersuchungen In vitro‐Untersuchungen Teratogenitätsstudien Untersuchungen zur gentoxischen Wirkung Untersuchungen zur kanzerogenen Wirkung Zur Frage eines MAK‐Wertes

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3‐Chlor‐1,2‐propandiol [MAK Value Documentation in German language, 1992]

2012

The MAK‐Collection for Occupational Health and Safety

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α‐Chlorohydrin [MAK Value Documentation, 1993]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 5 (1993) The article contains sections titled: Toxic Effects and Modes of Action Pharmacokinetics Effects in Man Effects on Animals Acute toxicity Subchronic and chronic toxicity Antifertility effects Genotoxicity Carcinogenicity Manifesto (MAK value, classification)

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Antifertility Potential of Ornidazole Analogues in Rats

COOPER,

YEUNG,

SKUPIN

et al. 1997

Journal of Andrology

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In order to determine which part of the ornidazole molecule [1‐(3‐chloro‐2‐hydroxy)propyhl‐2‐methyl‐5‐nitroimidazole] is responsible for its antifertility action, structural analogues were fed to male rats of proven fertility at doses equivalent to the antifertility dose of ornidazole (1.82 mmol/kg/day). The fertility of the males was tested, before oral gavage (control mating) and after 10 and 14 days of feeding, by counting the number of fetuses and corpora lutea present in females 12 days after mating. The day after the last mating, the kinematic parameters of sperm from the cauda epididymldis were assessed objectively with a Hamilton‐Thome motility analyzer. Analogues bearing the 2‐nitro and 5‐methyl groups on the imidazole ring were inactive if the (chlorohydroxy)propyl group were substituted by proton or methyl, hydroxyethyl, chloroethyl, or (sulfonylethyl)ethyl groups, indicating that the three‐carbon side chain of ornidazole was necessary for the antifertility action. Only ornidazole and its acetate were effective antifertility agents, but a compound bearing the (chlorohydroxy)propyi side chain attached to a nitrogen atom of a heterocyclic phthalimide produced a partial but temporary reduction in fertility. Similarities of the action of ornidazole with the male antifertility agent, α‐chbrohydrin [3‐chloro‐1,2‐propanediol], are discussed.

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Antifertility Activity and Toxicity of a-Chlorohydrin Aromatic Ketal Analogues in Male Rats

Cited by 5 publications

References 11 publications

3‐Chlor‐1,2‐propandiol [MAK Value Documentation in German language, 1992]

3‐Chlor‐1,2‐propandiol [MAK Value Documentation in German language, 1992]

α‐Chlorohydrin [MAK Value Documentation, 1993]

Antifertility Potential of Ornidazole Analogues in Rats

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