Antifeedant effect of polygodial and drimenol derivatives against <scp><i>Spodoptera frugiperda</i></scp> and <i>Epilachna paenulata</i> and quantitative structure‐activity analysis

Montenegro, Iván; Corral, Soledad del; Napal, Georgina Natalia Díaz; Carpinella, María Cecilia; Mellado, Marco; Madrid, Alejandro; Villena, Joan; Palacios, Sara M.; Cuéllar, Mauricio

doi:10.1002/ps.4853

Cited by 11 publications

(8 citation statements)

References 44 publications

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“…The decrease in consumption rate may be due to antifeedant effect of the compound. The same trend was observed in S. litura treated with methanolic flower extract of Chrysanthemum fuscatum [ 27 ] and secondary metabolite treatment of S. litura [ 28 , 29 ]. Similarly, Koul et al [ 30 ] observed that aglaroxin A inhibited the food intake.…”

Section: Discussionsupporting

confidence: 69%

Toxicity of Bioactive Molecule Andrographolide against Spodoptera litura Fab and Its Binding Potential with Detoxifying Enzyme Cytochrome P450

et al. 2021

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Spodoptera litura Fab. is a polyphagous pest causing damage to many agriculture crops leading to yield loss. Recurrent usage of synthetic pesticides to control this pest has resulted in resistance development. Plant-derived diterpenoid compound andrographolide was isolated from the leaves of Andrographis paniculata. It was analysed by gas chromatography-mass spectroscopy and quantified by HPLC. Nutritional indices and digestive enzymatic profile were evaluated. Third, fourth and fifth instar larvae were treated with different concentrations of andrographolide. At 3, 6 and 9 ppm-treated concentrations the larvae showed decreased RGR, RCR, ECI, ECD values with adverse increase in AD. The digestive enzymes were significantly inhibited when compared with control. Conspicuously, andrographolide showed pronounced mortality of S. litura by inhibition of enzyme secretion and intake of food. The binding ability of andrographolide with CYTP450 showed high affinity with low binding energy. Andrographolide has the potential to be exploited as a biocontrol agent against S. litura as an eco-friendly pesticide.

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Section: Discussionsupporting

confidence: 69%

Toxicity of Bioactive Molecule Andrographolide against Spodoptera litura Fab and Its Binding Potential with Detoxifying Enzyme Cytochrome P450

et al. 2021

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“…Canelo bioactivity has been reported from its compounds and EOs obtained from its stems, leaves and bark. Phytochemical studies have shown the activity of polygodial and drimenol sesquiterpenes for medical applications [23], as well as pest control [24,25]. Moreover, the D. winteri EO has produced insecticidal activity against aphids [26], stored grain insects [27] and weevils [28], showing great potential as a natural pesticide.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Drimys winteri (Canelo) Essential Oil as Insecticide against Acanthoscelides obtectus (Coleoptera: Bruchidae) and Aegorhinus superciliosus (Coleoptera: Curculionidae)

Tampe

Espinoza

Chacón-Fuentes

et al. 2020

Insects

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Adverse effects caused by synthetic pesticides have increased interest in plant-derived insecticidal compounds, in particular essential oils, as a more compatible and ecofriendly alternative for pest control of economic importance. For this reason, the essential oil isolated from leaves and shoots of Drimys winteri (J.R. Forster & G. Forster)—also named canelo (CEO)—was investigated for its chemical profile and insecticidal action against Acanthoscelides obtectus (Say)—one of the most important post-harvest pests of dry beans in the world—and Aegorhinus superciliosus (Guérin)—a significant pest of fruit trees in Chile. The analysis by gas chromatography, paired with mass spectrometry (GC/MS) determined 56 compounds, corresponding to 92.28% of the detected compounds. Elemol (13.54%), γ-eudesmol (11.42%), β-eudesmol (8.49%), α-eudesmol (6.39%), α-pinene (7.92%) and β-pinene (5.17%) were the most abundant. Regarding the bioactivity of the CEO, the results demonstrated toxicological effects against A. obtectus. A concentration of 158.3 µL L−1 had a mortality rate of 94% after 24 h exposure. The LC50 and LC90 values at 24 h were 60.1 and 163.0 µL L−1. Moreover, behavioral bioassays showed a repellent effect against A. superciliosus with a dose of one microliter of CEO. Both sexes of the raspberry weevil stayed for very short times in the treated area with the oil (<0.8 min), showing a homogeneous repellency in the species. The overall data suggest that canelo leaves and shoots essential oil has an insecticide effect and is worth exploring to better understand the synergistic relationship between the compounds present in the essential oil.

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“…Apart from the anti-feedant activity against a number of pests [ 1 , 2 , 3 ], polygodial ( Figure 1 ) has been reported to possess biological activities such as antifungal [ 4 , 5 , 6 ], antibacterial [ 7 ], anti-tumor [ 8 ], larvicidal [ 9 ], antihelminthic [ 10 ], antifouling [ 11 ], anti-inflammatory [ 12 ], analgesic [ 13 ], antitrypanosomal, and antileishmanial activities [ 14 ]. As a bioactive constituent, it is produced in several plants of the Canellaceae [ 1 ], Polygonaceae [ 15 ], and Winteraceae [ 16 ] families, as well as in marine animals such as sponges and molluscs [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae

Kipanga

Demuyser

Vrijdag

et al. 2021

IJMS

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Polygodial is a “hot” peppery-tasting sesquiterpenoid that was first described for its anti-feedant activity against African armyworms. Using the haploid deletion mutant library of Saccharomyces cerevisiae, a genome-wide mutant screen was performed to shed more light on polygodial’s antifungal mechanism of action. We identified 66 deletion strains that were hypersensitive and 47 that were highly resistant to polygodial treatment. Among the hypersensitive strains, an enrichment was found for genes required for vacuolar acidification, amino acid biosynthesis, nucleosome mobilization, the transcription mediator complex, autophagy and vesicular trafficking, while the resistant strains were enriched for genes encoding cytoskeleton-binding proteins, ribosomal proteins, mitochondrial matrix proteins, components of the heme activator protein (HAP) complex, and known regulators of the target of rapamycin complex 1 (TORC1) signaling. WE confirm that polygodial triggers a dose-dependent vacuolar alkalinization and that it increases Ca2+ influx and inhibits glucose-induced Ca2+ signaling. Moreover, we provide evidence suggesting that TORC1 signaling and its protective agent ubiquitin play a central role in polygodial resistance, suggesting that they can be targeted by polygodial either directly or via altered Ca2+ homeostasis.

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Antifeedant effect of polygodial and drimenol derivatives against Spodoptera frugiperda and Epilachna paenulata and quantitative structure‐activity analysis

Cited by 11 publications

References 44 publications

Toxicity of Bioactive Molecule Andrographolide against Spodoptera litura Fab and Its Binding Potential with Detoxifying Enzyme Cytochrome P450

Toxicity of Bioactive Molecule Andrographolide against Spodoptera litura Fab and Its Binding Potential with Detoxifying Enzyme Cytochrome P450

Evaluation of Drimys winteri (Canelo) Essential Oil as Insecticide against Acanthoscelides obtectus (Coleoptera: Bruchidae) and Aegorhinus superciliosus (Coleoptera: Curculionidae)

Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae

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