Antifeedant Activity of Metabolites from Viguiera Tucumanensis

Vaccarini, Clarisa E.; Palacios, Sara M.; Meragelman, Karina M.; Sosa, Virginia E.

doi:10.1080/10575630290030711

Cited by 3 publications

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“…Owing to the little quantity obtained of this compound, no bioassays were developed assessing its activity. Concerning the activity of this compound against insects, to our knowledge, there is in literature only one report of its activity against E. paenulata [62]. Moreover, the group of the clerodanes has been described mainly from Lamiaceae and Asteraceae, and they have exhibited a wide range of anti-insect properties as it has been reviewed previously [63]- [65].…”

Section: Resultsmentioning

confidence: 99%

Differential Deterrent Activity of Natural Products Isolated from <i>Allophylus edulis</i> (Sapindaceae)

Díaz¹,

Castillo²,

Díaz³

et al. 2014

ABC

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The phytochemical study of Uruguayan specimens of Allophylus edulis (Sapindaceae) yielded the isolation of various natural products being some of them reported for the first time in this species. Although most of them are ubiquitous in the plant kingdom, some revealed in this study to have anti insect properties. Two sesquiterpenes (6,7-Epoxicaryophyllene and spathulenol), two phytosterols (sitosterone and sitosterol), a pentacyclic triterpene (lupeol) and a clerodane diterpene were isolated. 6,7-Epoxycaryophyllene, lupeol and sitosterol showed to be deterrent against the aphid Myzus persicae and the coleopteran Epilachna paenulata. Moreover, the crude ethanolic extract of twigs of A. edulis showed to be deterrent against both insect species being some of its fractions also active against another aphid, Rhopalosiphum padi. Various active compounds against different insect models have been isolated from the twigs extract of A. edulis. The results evidenced synergic as well as antagonistic effects in the mixture, summed to differential activity against the insects, a desirable attribute when developing botanical pesticides.

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Section: Resultsmentioning

confidence: 99%

Differential Deterrent Activity of Natural Products Isolated from <i>Allophylus edulis</i> (Sapindaceae)

Díaz¹,

Castillo²,

Díaz³

et al. 2014

ABC

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Cytotoxic Activity of Extracts from Plants of Central Argentina on Sensitive and Multidrug‐Resistant Leukemia Cells: Isolation of an Active Principle from Gaillardia megapotamica

González

Joray

Laiolo

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Plants are a significant reservoir of cytotoxic agents, including compounds with the ability to interfere with multidrug-resistant (MDR) cells. With the aim of finding promising candidates for chemotherapy, 91 native and naturalized plants collected from the central region of Argentina were screened for their cytotoxic effect toward sensitive and MDR P-glycoprotein (P-gp) overexpressing human leukemia cells by means of MTT assays. The ethanol extracts obtained from Aldama tucumanensis, Ambrosia elatior, Baccharis artemisioides, Baccharis coridifolia, Dimerostemma aspilioides, Gaillardia megapotamica, and Vernonanthura nudiflora presented outstanding antiproliferative activity at 50 μg/mL, with inhibitory values from 93 to 100%, when tested on the acute lymphoblastic leukemia (ALL) cell line CCRF-CEM and the resistant derivative CEM-ADR5000, while 70–90% inhibition was observed against the chronic myelogenous leukemia (CML) cell K562 and its corresponding resistant subline, Lucena 1. Subsequent investigation showed these extracts to possess marked cytotoxicity with IC50 values ranging from 0.37 to 29.44 μg/mL, with most of them being below 7 μg/mL and with ALL cells, including the drug-resistant phenotype, being the most affected. G. megapotamica extract found to be one of the most effective and bioguided fractionation yielded helenalin (1). The sesquiterpene lactone displayed IC50 values of 0.63, 0.19, 0.74, and 0.16 μg/mL against K562, CCRF-CEM, Lucena 1, and CEM/ADR5000, respectively. These results support the potential of these extracts as a source of compounds for treating sensitive and multidrug-resistant leukemia cells and support compound 1 as a lead for developing effective anticancer agents.

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Secondary metabolites in Viguiera (Compositae, Heliantheae, Helianthinae) and segregated genera. A review of their biological activities with chemotaxonomic observations

et al. 2022

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Background: The first monograph of the genus Viguiera was published in 1918 by Blake, including about 141 species. Schilling & Panero based on studies of molecular sequences of nuclear Internal Transcribed Spacer and External Transcribed Spacer, as well as cpDNA, proposed to reclassify the genus, relocating its species in at least other nine genera. Question: Is it possible to identify distinctive patterns between the species of the new classification of Viguiera s. l. and the results of the chemical studies reported? Species considered: Sixty-seven species within the wide Viguiera circumscription with chemical studies and biological activities reported. Results: The species of the genus Viguiera synthesize terpenoids represented mainly by sesquiterpene lactones and diterpenes, with triterpenes, polyacetylenes, volatile terpenoids and flavonoids also present. The main types of secondary metabolites were present in the studied species, although some compounds were more frequent than others in some clades. Conclusion: Germacrolides, heliangolides, furanoheliangolides, tetracyclic diterpenes and flavonoids are the main constituents of Viguiera and segregated genera. Some interesting chemotaxonomic relationships are noted. Nevertheless, nondistinctive clear patterns were observed between clades and chemical groups. These results may be a consequence of the reported chemical studies of the species of Viguiera s. l., which have not agreed on objetives or methodologies.

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Antifeedant Activity of Metabolites from Viguiera Tucumanensis

Abstract: Several terpenoids and clerod-14-ene-3alpha, 4beta,13xi-triol (1), the main compound of V. tucumanensis, were isolated and bioassayed. The clerodane 1 showed higher antifeedant activity than other related compounds. Structure-activity relationships are also discussed.

Cited by 3 publications

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Differential Deterrent Activity of Natural Products Isolated from <i>Allophylus edulis</i> (Sapindaceae)

Differential Deterrent Activity of Natural Products Isolated from <i>Allophylus edulis</i> (Sapindaceae)

Cytotoxic Activity of Extracts from Plants of Central Argentina on Sensitive and Multidrug‐Resistant Leukemia Cells: Isolation of an Active Principle from Gaillardia megapotamica

Secondary metabolites in Viguiera (Compositae, Heliantheae, Helianthinae) and segregated genera. A review of their biological activities with chemotaxonomic observations

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Antifeedant Activity of Metabolites from Viguiera Tucumanensis

Abstract: Several terpenoids and clerod-14-ene-3alpha, 4beta,13xi-triol (1), the main compound of V. tucumanensis, were isolated and bioassayed. The clerodane 1 showed higher antifeedant activity than other related compounds. Structure-activity relationships are also discussed.

Cited by 3 publications

References 0 publications

Differential Deterrent Activity of Natural Products Isolated from &lt;i&gt;Allophylus edulis&lt;/i&gt; (Sapindaceae)

Differential Deterrent Activity of Natural Products Isolated from &lt;i&gt;Allophylus edulis&lt;/i&gt; (Sapindaceae)

Cytotoxic Activity of Extracts from Plants of Central Argentina on Sensitive and Multidrug‐Resistant Leukemia Cells: Isolation of an Active Principle from Gaillardia megapotamica

Secondary metabolites in Viguiera (Compositae, Heliantheae, Helianthinae) and segregated genera. A review of their biological activities with chemotaxonomic observations

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Differential Deterrent Activity of Natural Products Isolated from <i>Allophylus edulis</i> (Sapindaceae)

Differential Deterrent Activity of Natural Products Isolated from <i>Allophylus edulis</i> (Sapindaceae)