Antiestrogen inhibition of estradiol-induced alterations in hypothalamic catecholamine turnover

Hiemke, Christoph; Hinze, Jonas; Ghraf, Rüdiger

doi:10.1530/acta.0.114s152a

Cited by 1 publication

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“…There is evidence that peripherally administered tamoxifen does indeed have central effects. For example, peripheral injections of monohydroxytamoxifen antagonize the estradiol-induced alterations in noradrenalin turnover in female rats (Hiemke, Poetz, and Ghraf, 1985), and peripherally administered tamoxifen blocks the estradiol-induced fivefold increase in dopamine turnover in the female rat medial basal hypothalamus (Toney and Katzenellenbogen, 1986). Thus, we predicted that if tamoxifen had its effects on the song system by acting in the brain, we would observe accumulation of tamoxifen or its metabolites in brain regions rich in estrogen-concentrating cells.…”

Section: Introductionmentioning

confidence: 99%

Tamoxifen fails to block estradiol accumulation, yet is weakly accumulated by the juvenile zebra finch anterior hypothalamus: An autoradiographic study

Mathews

Arnold

1991

J. Neurobiol.

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In experiment 1, we used autoradiographic procedures to examine whether tamoxifen could displace 3H-estradiol labeling in the anterior hypothalamus and the caudal nucleus of the ventral hyperstriatum (HVc) of ovariectomized 20-day-old female zebra finches. There was no significant reduction in labeling of cells by 3H-estradiol in birds preinjected with unlabeled tamoxifen. In experiment 2, we found that injections of 3H-tamoxifen caused-weak labeling of cells in the anterior hypothalamus of 20-day-old male and female zebra finches. These results are compatible with the idea that tamoxifen does not block the action of estradiol in the brain of zebra finches, and suggest that the effects of early tamoxifen treatment on the morphology of the song system may reflect central actions of tamoxifen.

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Section: Introductionmentioning

confidence: 99%