Antiepileptic effects of electroacupuncture vs vagus nerve stimulation on cortical epileptiform activities

Zhang, Jian Liang; Zhang, Shi Ping; Zhang, Hong Qi

doi:10.1016/j.jns.2008.02.015

Cited by 15 publications

(4 citation statements)

References 25 publications

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“…They did not find that VNS reduced interictal spikes and provided negative results [22][23][24]. Moreover, it is still on argument that whether this effect of VNS on interictal EEG is immediate/acute or chronic [12,22,25,26]. This is a pilot study that describes the long-term interictal EEG changes through the first group of VNS patients with refractory epilepsy in two departments (in Harbin and Shanghai, China).…”

Section: Introductionmentioning

confidence: 99%

Long-term effect of vagus nerve stimulation on interictal epileptiform discharges in refractory epilepsy

Wang

Chen

Lin

et al. 2009

Journal of the Neurological Sciences

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Section: Introductionmentioning

confidence: 99%

Long-term effect of vagus nerve stimulation on interictal epileptiform discharges in refractory epilepsy

Wang

Chen

Lin

et al. 2009

Journal of the Neurological Sciences

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“…Investigations involving various acupuncture points have highlighted their effects on the thalamus. For instance, stimulating the Dazhui (GV14) point has been shown to mainly inhibit epileptiform activities prompted by pentylenetetrazole (PTZ) within ventrobasal thalamic neurons [ 30 ]. Similarly, stimulating the Yanglingquan (GB34) point can modulate thalamic gene expression [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Effect on Satisfactory Seizure Control and Heart Rate Variability of Thread-Embedding Acupuncture for Drug-Resistant Epilepsy: A Patient-Assessor Blinded, Randomized Controlled Trial

Nguyen,

Pham,

et al. 2023

Behavioural Neurology

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This randomized controlled trial investigates the efficacy of thread-embedding acupuncture (TEA) compared to sham TEA in treating drug-resistant epilepsy (DRE). Fifty-four DRE outpatients were randomly divided into two groups: TEA (27 patients) and sham TEA (27 patients). Both groups received four sessions of TEA or sham TEA, spaced four weeks apart, targeting GV20, GV14, BL15, BL18, ST40, and GB34 acupoints. Antiseizure medications were maintained at consistent doses throughout the study. Outcome measures included satisfactory seizure control, seizure freedom, and heart rate (HR) and heart rate variability (HRV) measurements. TEA demonstrated a significantly higher rate of satisfactory seizure control at follow-up compared to the sham TEA group (37% vs. 3.7%, p = 0.003 ). While no significant intergroup differences were observed in HR, HRV, and HRV components at each stage, the TEA group experienced a significant decrease in HR and a significant increase in HRV posttreatment. This study demonstrates TEA’s effectiveness in managing DRE and suggests its impact may relate to heightened parasympathetic nerve activity. Further research with extended follow-up periods is necessary to validate these findings.

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“…Stimulation of the vagus nerve decreased immobility in the FST in mice in a 5-HT-dependent manner [117], while it also reduced PTZ-induced cortical electrographic spiking in rats [118]. Consistent with the antidepressant and anticonvulsant properties of NE discussed in section 3.1.5, multiple effects of VNS were dependent upon an intact locus coeruleus [86], suggesting the augmentation of noradrenergic function underlies its therapeutic efficacy.…”

Section: Potential Mechanisms and Therapeutic Targetsmentioning

confidence: 98%

Rhythm and blues: Animal models of epilepsy and depression comorbidity

Epps

Weinshenker

2013

Biochemical Pharmacology

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Clinical evidence shows a strong, bidirectional comorbidity between depression and epilepsy that is associated with decreased quality of life and responsivity to pharmacotherapies. At present, the neurobiological underpinnings of this comorbidity remain hazy. To complicate matters, anticonvulsant drugs can cause mood disturbances, while antidepressant drugs can lower seizure threshold, making it difficult to treat patients suffering from both depression and epilepsy. Animal models have been created to untangle the mechanisms behind the relationship between these disorders and to serve as screening tools for new therapies targeted to treat both simultaneously. These animal models are based on chemical interventions (e.g. pentylenetetrazol, kainic acid, pilocarpine), electrical stimulations (e.g. kindling, electroshock), and genetic/selective breeding paradigms (e.g. Genetically Epilepsy-Prone Rats (GEPRs), Genetic Absence Epilepsy Rat from Strasbourg (GAERS), WAG/Rij rats, Swim Lo-Active rats (SwLo)). Studies on these animal models point to some potential mechanisms that could explain epilepsy and depression comorbidity, such as various components of the dopaminergic, noradrenergic, serotonergic, and GABAergic systems, as well as key brain regions, like the amygdala and hippocampus. These models have also been used to screen possible therapies. The purpose of the present review is to highlight the importance of animal models in research on comorbid epilepsy and depression and to explore the contributions of these models to our understanding of the mechanisms and potential treatments for these disorders.

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Antiepileptic effects of electroacupuncture vs vagus nerve stimulation on cortical epileptiform activities

Cited by 15 publications

References 25 publications

Long-term effect of vagus nerve stimulation on interictal epileptiform discharges in refractory epilepsy

Long-term effect of vagus nerve stimulation on interictal epileptiform discharges in refractory epilepsy

Effect on Satisfactory Seizure Control and Heart Rate Variability of Thread-Embedding Acupuncture for Drug-Resistant Epilepsy: A Patient-Assessor Blinded, Randomized Controlled Trial

Rhythm and blues: Animal models of epilepsy and depression comorbidity

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