Antiepileptic effects of antioxidant potent extract from Urtica dioica Linn. root on pentylenetetrazole and maximal electroshock induced seizure models

Loshali, Aanchal; Joshi, B. C.; Sundriyal, Ankush; Uniyal, Sushmita

doi:10.1016/j.heliyon.2021.e06195

Cited by 13 publications

(6 citation statements)

References 38 publications

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“…In particular, extracts from Urtica dioica Linn. root or Lactuca serriola (Asteraceae) can cause antiepileptic effects in pentylenetetrazole-induced seizure models ( Loshali et al, 2021 ). Among flavonoids, chrysin, resveratrol, baicalein, quercetin, and rutin produced significant anti-seizure activity or mild sedative and anxiolytic effects ( Ullah et al, 2022 ; Karioti et al, 2016).…”

Section: Phenols and Neuropsychiatric Disordersmentioning

confidence: 99%

Phenols and GABAA receptors: from structure and molecular mechanisms action to neuropsychiatric sequelae

Menzikov,

Zaichenko,

Moskovtsev

et al. 2024

Front. Pharmacol.

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γ-Aminobutyric acid type A receptors (GABAARs) are members of the pentameric ligand-gated ion channel (pLGIC) family, which are widespread throughout the invertebrate and vertebrate central nervous system. GABAARs are engaged in short-term changes of the neuronal concentrations of chloride (Cl−) and bicarbonate (HCO3−) ions by their passive permeability through the ion channel pore. GABAARs are regulated by various structurally diverse phenolic substances ranging from simple phenols to complex polyphenols. The wide chemical and structural variability of phenols suggest similar and different binding sites on GABAARs, allowing them to manifest themselves as activators, inhibitors, or allosteric ligands of GABAAR function. Interest in phenols is associated with their great potential for GABAAR modulation, but also with their subsequent negative or positive role in neurological and psychiatric disorders. This review focuses on the GABAergic deficit hypotheses during neurological and psychiatric disorders induced by various phenols. We summarize the structure–activity relationship of general phenol groups concerning their differential roles in the manifestation of neuropsychiatric symptoms. We describe and analyze the role of GABAAR subunits in manifesting various neuropathologies and the molecular mechanisms underlying their modulation by phenols. Finally, we discuss how phenol drugs can modulate GABAAR activity via desensitization and resensitization. We also demonstrate a novel pharmacological approach to treat neuropsychiatric disorders via regulation of receptor phosphorylation/dephosphorylation.

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Section: Phenols and Neuropsychiatric Disordersmentioning

confidence: 99%

Phenols and GABAA receptors: from structure and molecular mechanisms action to neuropsychiatric sequelae

Menzikov,

Zaichenko,

Moskovtsev

et al. 2024

Front. Pharmacol.

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“…In a study evaluating the antiepileptic effect of UD, the antioxidant activity of UD root extract was studied in different solvents using the DPPH assay. The highest antioxidant activity was observed using ethyl acetate as a solvent, and this was selected for further antiepileptic study on a mouse model of seizure [ 63 ].…”

Section: Antioxidant Potential Of Udmentioning

confidence: 99%

Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities

Jaiswal

Lee

2022

Antioxidants

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Urtica dioica (UD) is a multi-functional plant known to be used as both food and medicine from ancient times. The plant has the potential to be used as a fertilizer and for biological pest control. It is also used in textile and related industries for its quality fibers. In the recent past, the plant has received great attention for its numerous important biological activities and food applications. The antioxidant activity of UD is the crucial factor supporting its important biological activities, such as anticancer, antidiabetic and anti-inflammatory properties. The antioxidant activity of UD is also found to be protective in different organs, including the brain, liver, lungs, kidney, ovary, and uterus, and may also be protective against diseases associated with these organs. Few clinical studies have endorsed the antioxidant potential of UD in patients. The current work is an attempt to comprehensively compile and discuss the antioxidant activity of UD from in vitro, in vivo and human studies. The insights of the current study would be helpful in getting a panoramic view of the antioxidant potential of UD, and provide direction for optimizing and developing it for therapeutic applications against important diseases and conditions in the near future.

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“…Yes (both hypoglycemic and anticonvulsant effects) (Kavalali et al, 2003;Loshali et al, 2021) -Urticarial rash -Increased sensitivity of breast cancer cells to paclitaxel -Upset stomach (Setty and Sigal, 2005) -Nettle seed extract may have the potential to inhibit and/or induce the metabolism of certain coadministered drugs due to effects on enzymes like CYP2C6 and CYP2E1 (Agus et al, 2009;Mohammadi et al, 2016) Gurmar (Gymnema sylvestre)…”

Section: European Blueberry (Vaccinium Myrtillus)mentioning

confidence: 99%

Use of Complementary and Alternative Medicine Among Patients With Epilepsy and Diabetes Mellitus, Focusing on the Outcome of Treatment

et al. 2022

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Introduction: Millions all over the world live with epilepsy, and they may require long-term drug treatment. The use and interest in complementary and alternative medicine (CAM) have grown over the previous years. Coadministration of herbal products with medicines may result in adverse drug reactions (ADRs) and/or unfavorable interactions. The aims of this study were to determine the prevalence of CAM use among patients with epilepsy, to compare the results to those of the patients with diabetes mellitus (DM), to reveal factors that may drive the use of CAM, and to measure outcomes and adherence. It was also our intent to have state-of-the-art information on CAM use in our region among patients with the two diseases above.Materials and Methods: We conducted a non-interventional study using a self-developed questionnaire. It was distributed among adult patients with either epilepsy or DM who also suffered from cardiovascular consequences. A database was compiled from the anonymous questionnaires filled in voluntarily by the patients. Basic statistics were used to analyze this database.Results: A total of 227 questionnaires were filled in by 127 patients (55.9%) with epilepsy and 100 patients (44.1%) with DM. Mean age was 54.54 ± 17.33 years. Of the patients, 50.2% were male. Average body weight was 80.3 ± 17.3 kg. Of the patients, 22 (9.7%) used CAM because they believed in CAM. Two of them reported ADRs. Among the patients with epilepsy, the ratio was only 7.9% compared to 12% among those with DM. While the number of CAM users was higher among younger patients with epilepsy, it was the elderly patients with DM who tended to use CAM.Conclusion: Attention should be paid to reliance on CAM during the follow-up. Our finding that health-conscious patients tend to use CAM more often (than the general population) may indicate it is necessary to discuss CAM usage sincerely. CAMs modulating cytochrome P450 (CYP) enzymes were the most common, leading to interactions with medication used and resulting in ADRs. This shows the importance of educating patients and treating team including clinical pharmacists in this field.

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Antiepileptic effects of antioxidant potent extract from Urtica dioica Linn. root on pentylenetetrazole and maximal electroshock induced seizure models

Cited by 13 publications

References 38 publications

Phenols and GABAA receptors: from structure and molecular mechanisms action to neuropsychiatric sequelae

Phenols and GABAA receptors: from structure and molecular mechanisms action to neuropsychiatric sequelae

Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities

Use of Complementary and Alternative Medicine Among Patients With Epilepsy and Diabetes Mellitus, Focusing on the Outcome of Treatment

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