Antiepileptic effect of uridine may be caused by regulating dopamine release and receptor expression in corpus striatum

Wang, Tianlin; Zhou, Xin; Bai, Yan; Zhang, Lan; Li, Lin; Wu, Chunfu

doi:10.1016/j.brainres.2018.03.011

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…Uridine, an endogenous neuromodulator, produced an antiepileptic effect against the status epilepticus model induced by lithium-pilocarpine (PC), and this action is related to the decreased expression of Drd2. 39) Given that Q808 also decreased the expression of Drd2, Q808 may be effective in controlling the seizure induced by PC. In addition, Q808 may affect schizophrenia, a neurological disorders which can be controlled with D2 antagonists.…”

Section: Discussionmentioning

confidence: 99%

Effects of Long-Term Administration of Q808 on Hippocampal Transcriptome in Healthy Rats

Wang

Zhang

et al. 2022

Chem. Pharm. Bull.

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Epilepsy treatment with antiepileptic drugs (AEDs) is usually requires for many years. Q808 is an innovative antiepileptic chemical. It exerts effective antiepileptic effect against various epilepsy models. Exploring the gene transcriptomic profile of long-term treatment of Q808 is necessary. In the present study, hippocampus RNAsequencing was performed to reveal the transcriptome profile of rats before and after treatment of Q808 for 28 days. Results confirmed 51 differentially expressed genes (DEGs) between Q808 and healthy control groups. Gene cluster analysis showed that most upregulated DEGs linked to response to drug and nucleus, most downregulated DEGs linked to locomotory, neuronal cell body, and drug binding. Most of DEGs were enriched in the signaling transduction, substance dependence, nervous system, and neurodegenerative disease pathways. Furthermore, quantitative real-time PCR analysis confirmed that Q808 significantly increased the expression of neuroprotective genes, such as Mdk, and decreased the mRNA levels of Penk, Drd1, and Adora2a, which are highly expressed in epilepsy models. In addition, Q808 decreased the mRNA expression of Pde10A and Drd2, which are known to be closely associated with schizophrenia. Our study may provide a theoretical basis to explore the effect of Q808 on the susceptibility to epilepsy and other neurological diseases.

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Section: Discussionmentioning

confidence: 99%