“…Given its pKa, Ketoprofen could be secreted with pancreatic and intestinal juice in agreement with the pH-partition theory, following a driving force given by the blood-juice difference of pHs. [18] , [19] , [20] R-to-S conversion of secreted drug following meal intakes with subsequent reabsorption into the systemic circulation could explain the evident S/R ratio increase. Ibuprofen, the most widely consumed NSAID, on the other hand, exhibits a much higher chiral inversion ratio of 63% of the oral administered drug and was therefore chosen for the present study.…”