Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a network meta-analysis

Piechotta, Vanessa; Adams, Anne; Haque, M Zahirul; Scheckel, Benjamin; Kreuzberger, Nina; Monsef, Ina; Jordan, Karin; Kuhr, Kathrin; Skoetz, Nicole

doi:10.1002/14651858.cd012775.pub2

Cited by 37 publications

(40 citation statements)

References 293 publications

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“…In this case, network meta-analysis (NMA) can provide direct and indirect comparisons among multiple interventions. 22 Therefore, this study attempts to compare the effects of different modalities of rTMS on upper limb motor function and activities of daily living in patients with stroke through NMA with both direct and indirect evidence. The first research question is: what isthe most effective rTMS modality on upper limb movement function and activities of daily living in patients with stroke?…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“…However, limited by the availability of pairwise comparisons between interventions, it is difficult to draw a conclusion about which is the most comparatively effective and safe stimulation modalities. In this case, network meta-analysis (NMA) can provide direct and indirect comparisons among multiple interventions 22. Therefore, this study attempts to compare the effects of different modalities of rTMS on upper limb motor function and activities of daily living in patients with stroke through NMA with both direct and indirect evidence.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Repetitive transcranial magnetic stimulation for upper limb motor function and activities of daily living in patients with stroke: a protocol of a systematic review and Bayesian network meta-analysis

Lü

Xia

et al. 2022

BMJ Open

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IntroductionPatients with stroke usually suffer from varying degrees of movement dysfunction, which seriously affects their quality of life, especially for the upper limb dysfunction. Therefore, this study aims to compare the effects of different repetitive transcranial magnetic stimulation (rTMS) modalities on upper limb motor function and daily activities in patients with stroke.Methods and analysisRelevant research will be collected systematically from PubMed, Web of Science, Embase, Cochrane Library, ProQuest, Wanfang Database, China National Knowledge Infrastructure and Chinese Scientific and Journal Database (VIP) about randomised controlled trials of rTMS in the stroke treatment range from the establishment to November 2020. Primary outcomes will be obtained from scales measuring the upper limb motor function like Upper Extremity Fugl-Meyer Assessment Scale, Wolf Motor Function Test, Jebsen-Taylor Hand Function Test, Action Research Arm Test and Box and Block Test. The secondary outcomes include modified Barthel Index and adverse events (such as vertigo, headache and epilepsy), with the goal of assessing patients’ activities of daily living and the safety of treatment. In order to avoid personal bias in the included studies, two reviewers will conduct the data extraction and quality evaluation independently, and all data analyses will be performed by Generate Mixed Treatment comparison software V.0.14.3 and Stata V.16.0.Ethics and disseminationThe network meta-analysis (NMA) in this study does not require ethical approval because the data analysis will be used only to evaluate the rTMS treatment efficacy without patients’ private information. In addition, the results will be disseminated in international conference reports and peer-reviewed manuscripts.PROSPERO registration numberCRD42020212253.

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Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation for upper limb motor function and activities of daily living in patients with stroke: a protocol of a systematic review and Bayesian network meta-analysis

Lü

Xia

et al. 2022

BMJ Open

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“…NK1 receptor antagonists are highly effective for treatment of nausea and vomiting, including highly emetogenic chemotherapy and post-operative nausea and vomiting as documented in systematic reviews and meta-analyses. [2][3][4] These effects are predominantly attributed to effects on NK1 receptors in the vomiting centre in the brainstem.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, tachykinins can inhibit motor activity by stimulating either inhibitory neuronal pathways or interrupting excitatory relays 1 . Therefore, the effects of an NK1 antagonist on regional gastrointestinal motor functions cannot be accurately predicted, and formal studies are needed to assess the potential pharmacodynamic effects of such pharmacological agents. NK1 receptor antagonists are highly effective for treatment of nausea and vomiting, including highly emetogenic chemotherapy and post‐operative nausea and vomiting as documented in systematic reviews and meta‐analyses 2–4 . These effects are predominantly attributed to effects on NK1 receptors in the vomiting centre in the brainstem. A review has summarised the important effects of NK receptor modulation on the neuromuscular apparatus in the gastrointestinal tract 5 .…”

Section: Introductionmentioning

confidence: 99%

Clinical trial: a single‐centre, randomised, controlled trial of tradipitant on satiation, gastric functions, and serum drug levels in healthy volunteers

Khanna

Zheng

Atieh

et al. 2022

Aliment Pharmacol Ther

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Summary Background Tradipitant, an NK1 receptor antagonist, improved symptoms in patients with gastroparesis. It is unclear whether these effects are mediated centrally (e.g., vomiting centre) or on gastric functions. As a class, NK1 antagonists may retard gastric emptying (GE) or increase fasting and postprandial gastric volumes (GV). Aim To evaluate the effects of tradipitant relative to placebo on gastric motor functions, satiation, postprandial symptoms, and pharmacokinetics. Methods We conducted a randomised, double‐blind, placebo‐controlled, single‐centre study of tradipitant 85 mg or matching placebo b.i.d. for 9 consecutive days in 24 healthy volunteers. During the last 2 days of treatment, participants underwent scintigraphic measurements of GE of 320 kcal egg meal, fasting and postprandial GV by SPECT, and satiation by nutrient drink ingested to maximum tolerated volume (MTV) and symptoms 30 min later. Treatments were compared by Wilcoxon rank sum test. The study had 80% power to detect group differences of 23.6% in GV and 29.2% in GE T1/2. Results The two groups of healthy participants were well balanced based on demographic features, age, and BMI. There were nonsignificant positive correlations between blood levels of tradipitant and accommodation GV and GE at 4 h. There were no significant effects of tradipitant, 85 mg b.i.d. for 9 days compared to placebo on GE, GV, satiation, or symptoms 30 min after MTV. Conclusion Tradipitant, 85 mg b.i.d., does not significantly affect gastric motor functions (GV or GE). Importantly, there was no retardation of GE by tradipitant, which is important in relation to its potential use in patients with gastroparesis. Clinic trials registry http://clinicaltrials.gov #NCT04849559.

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“…However, beware of catecholamine-induced QTc prolongation and avoid 5-HT 3 receptor antagonists as the QTc interval approaches >500 ms [17]. Neurokinin-1 receptor antagonists (e.g., aprepitant) which antagonize the binding of substance P, though costly, may be particularly useful as an antiemetic in these patients, as chromaffin tumors may secrete substance P [18][19][20].…”

Section: Catecholamine Excess and Management: Gastrointestinal Systemmentioning

confidence: 99%

Supportive management of patients with pheochromocytoma/paraganglioma undergoing noninvasive treatment

Talvacchio¹,

Nazari²,

Pacák³

2022

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of reviewMany publications review perioperative management of pheochromocytomas/paragangliomas (PPGLs); however, a large population, including 10--20% of metastatic PPGL patients, have inoperable disease. This has necessitated the development of noninvasive treatments (e.g., radio/chemotherapy), which, in affording disease-modification, have led to an ever-growing population of surviving patients with inoperable PPGL. These patients experience debilitating symptoms arising from discomforts related to the masses themselves (e.g., pain from osseous metastasis) and symptoms from tumoral catecholamine production and release. Unfortunately, management of these conditions is not yet well-defined. Adding further insult-to-injury, these noninvasive treatments can trigger catecholamine release, worsening catecholamine-induced symptoms. Herein, we detail these ailments and their management, especially while patients receive these noninvasive treatments. Recent findingsImproved diagnostic evaluations have allowed for earlier detection of PPGL, prolonging survival in patients with inoperable PPGLs. Accordingly, noninvasive treatment strategies have rapidly evolved alongside stateof-the-art theranostics and genetic testing, which inform ongoing management and therapeutic response.

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Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a network meta-analysis

Cited by 37 publications

References 293 publications

Repetitive transcranial magnetic stimulation for upper limb motor function and activities of daily living in patients with stroke: a protocol of a systematic review and Bayesian network meta-analysis

Repetitive transcranial magnetic stimulation for upper limb motor function and activities of daily living in patients with stroke: a protocol of a systematic review and Bayesian network meta-analysis

Clinical trial: a single‐centre, randomised, controlled trial of tradipitant on satiation, gastric functions, and serum drug levels in healthy volunteers

Supportive management of patients with pheochromocytoma/paraganglioma undergoing noninvasive treatment

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