Antidopaminergic Effect of Estrogens at the Striatal Level

Euvrard, C.; Labrie, Fernand; Boissier, Jacques R.

doi:10.1016/b978-1-4832-8363-0.50386-4

Cited by 14 publications

(16 citation statements)

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“…It was subsequently fo und that prolactin producing pituitary grafts under the kidney capsule in the absence of estro gen reinstate the same effect as was obtained by giving the synthetic estrogens: i.e. apomorphine-induced elevation of ACh is reduced, suggest ing that a pituitary fa ctor (possibly prolactin) inhibits response of dopamin ergic receptors (124). Another estrogen effect, namely, to elevate binding of 3H spiperone, is reportedly abolished by hypophysectomy (125) and mi micked by prolactin administration (126).…”

Section: Striatummentioning

confidence: 75%

“…On the other hand, estrogen treatment can also apparently antagonize dopaminer gic fu nction: e.g. estrogen treatment potentiates catalepsy resulting from spiperone administration (134); it reduces the increase in striatal acetylcho line levels elicited by dopamine agonists (15); it reduces the amount of apomorphine-induced rotation in unilaterally-lesioned rats (124,135); it attenuates phenylethylamine and amphetamine-induced stereotypy in mice (136); it reduces the magnitude of apomorphine-elicited stereotyped behav ior in female rats chronically pretreated with haloperidol (137); and it has a biphasic effect on apomorphine-induced stereotypy in rats not treated with haloperidol (123).…”

Section: Striatummentioning

confidence: 99%

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Gonadal Steroid Action on the Brain: Neurochemistry and Neuropharmacology

McEwen¹,

Parsons²

1982

Annu. Rev. Pharmacol. Toxicol.

188

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INTRODUCTIONSteroid hormones of the gonads and adrenals influence the brain and alter the affective state as well as· overt behavior and neuroendocrine function. These actions are manifested in various ways and at various levels of obser vation and experimentation. For example, in female vertebrates of many species, estrogens prime the brain and pituitary gland and make possible the occurrence of ovulation and sexual receptivity. Androgens, On the other hand, facilitate male reproductive behavior including vocalizations (e.g. song in passerine birds, mate-calling in frogs), defense of territory and related aggressive displays, and copulatory behavior. At another level of analysis, estrogen treatment counteracts tardive diskinesia and L-DOPA induced diskinesia (1) and has antidepressant effects in women resistant to other kinds of antidepressant drug therapy (2). Moreover, changes in estro gen and progestin levels are often linked to the emotional lability associated with the premenstrual and postpartum periods (3, 4).Studies of the action of steroid honnones on the brain have progressed to a point where specific mechanisms and brain sites of action are now recognized. Especially important to the neurophannacologist are those aspects of mechanism which have begun to deal with hormonal modifica tion of properties and functions of synapses. Synaptic function and neuro transmission are indeed the common currency for the analysis of neuroendocrine events and honnone-regulated behaviors, as well as other aspects of brain function; and the study of drugs which modify neurotrans mission through blockade of synthesis, degradation, reuptake, and recep-555 0362-1642/82/0415-0555$02.00 Annu. Rev. Pharmacol. Toxicol. 1982.22:555-598. Downloaded from www.annualreviews.org Access provided by University of California -San Francisco UCSF on 02/04/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS 556 MCEWEN & PARSONStors has produced a substantial literature implicating certain neuro transmitter candidates in those neuroendocrine and behavioral events. This article will summarize both hormone (especially gonadal steroid) action on synaptic properties and functions and the neuropharmacology of two well studied hormone-regulated events, the control of feminine sexual behavior and ovulation in rodents. Out of this summary will emerge, we hope, some generalizations which will help to guide future research.

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Section: Striatummentioning

confidence: 75%

Section: Striatummentioning

confidence: 99%

Gonadal Steroid Action on the Brain: Neurochemistry and Neuropharmacology

McEwen¹,

Parsons²

1982

Annu. Rev. Pharmacol. Toxicol.

188

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“…Previous studies showed that in OVX rats, 17b-estradiol can reverse psychosis-mimicking abnormalities induced by dopamine agonists, including hyperactivity, stereotypy and circling (Becker and Beer, 1986;Becker and Rudick, 1999;Bedard et al, 1983;Bedard et al, 1978;Earley and Leonard, 1978;Euvrard et al, 1979;Euvrard et al, 1980;Gordon, 1980;Gordon and Diamond, 1981;Naik et al, 1978), disrupted PPI , and disrupted LI Weiner, 2009, 2010). To the best of our knowledge, this is the first demonstration that 17b-estradiol exerts an antipsychotic action in gonadally intact rats of both sexes.…”

Section: Reversal Of Disrupted Li: Putative Efficacy For Positive Symmentioning

confidence: 93%

Sex-Dependent Antipsychotic Capacity of 17β-Estradiol in the Latent Inhibition Model: A Typical Antipsychotic Drug in Both Sexes, Atypical Antipsychotic Drug in Males

Arad

Weiner

2010

Neuropsychopharmacol

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The estrogen hypothesis of schizophrenia suggests that estrogen is a natural neuroprotector in women and that exogenous estrogen may have antipsychotic potential, but results of clinical studies have been inconsistent. We have recently shown using the latent inhibition (LI) model of schizophrenia that 17β-estradiol exerts antipsychotic activity in ovariectomized (OVX) rats. The present study sought to extend the characterization of the antipsychotic action of 17β-estradiol (10, 50 and 150 μg/kg) by testing its capacity to reverse amphetamine- and MK-801-induced LI aberrations in gonadally intact female and male rats. No-drug controls of both sexes showed LI, ie, reduced efficacy of a previously non-reinforced stimulus to gain behavioral control when paired with reinforcement, if conditioned with two but not five tone-shock pairings. In both sexes, amphetamine (1 mg/kg) and MK-801 (50 μg/kg) produced disruption (under weak conditioning) and persistence (under strong conditioning) of LI, modeling positive and negative/cognitive symptoms, respectively. 17β-estradiol at 50 and 150 μg/kg potentiated LI under strong conditioning and reversed amphetamine-induced LI disruption in both males and females, mimicking the action of typical and atypical antipsychotic drugs (APDs) in the LI model. 17β-estradiol also reversed MK-induced persistent LI, an effect mimicking atypical APDs and NMDA receptor enhancers, but this effect was observed in males and OVX females but not in intact females. These findings indicate that in the LI model, 17β-estradiol exerts a clear-cut antipsychotic activity in both sexes and, remarkably, is more efficacious in males and OVX females where it also exerts activity considered predictive of anti-negative/cognitive symptoms.

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“…In addition to reproductive and sexual behavior, a variety of behavioral patterns are organized and sexually differentiated in rodents under the influence of perinatal gonadal hormones (Beatty 1979;McClusky 1981;McEwen 1992). Recent advances in the neurosciences have shown that estrogens interact with the dopaminergic (Alderson and Baum 1981;Becker 1999;Euvrard et al 1980;Hruska and Pitman 1982;Menniti and Baum 1981;Peris et al 1991) and the serotonergic (Osterlund et al 2000;Osterlund and Hurd 1998) brain systems. Perinatal exposure to estrogenic pollutants could hence alter development of these major neurochemical pathways (see, e.g., Christian and Gillies 1999;Lilienthal et al 1997), leading to permanent neurobehavioral alterations in the offspring.…”

mentioning

confidence: 99%

Altered profiles of spontaneous novelty seeking, impulsive behavior, and response to D-amphetamine in rats perinatally exposed to bisphenol A.

Adriani

Seta²,

Dessì‐Fulgheri³

et al. 2003

Environ Health Perspect

107

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Bisphenol A (BPA) is an environmental estrogen with potentially averse effects on public health. We studied the long-term effects of perinatal exposure to BPA on later behavior in adult rats of both sexes. BPA or vehicle was administered orally to mother rats from mating to pups' weaning, at a concentration (0.040 mg/kg) within the range of human exposure. The offspring of both sexes were tested at adolescence (postnatal days 35-45) for novelty preference (experiment 1). After a 3-day familiarization to one side of a two-chamber apparatus, on day 4 rats were allowed to freely explore the whole apparatus. BPA-exposed females spent significantly less time than did controls in exploration of the novel side (i.e., increased neophobia), whereas no effect was found in the male group. At adulthood, the same animals were food deprived and tested for profiles of impulsive behavior (experiment 2), in operant chambers provided with two nose-poking holes (delivering either five or one food pellet). After the establishment of a baseline preference for the large reinforcer, a delay was introduced before the delivery of the five food pellets, which was progressively increased each day (10, 20, 30, 45, 60, 80, 100 sec). As expected, all animals exhibited a progressive shift toward the immediate but smaller reinforcer. A reduced level of impulsive behavior (i.e., a shift to the right in the intolerance-delay curve) was evidenced in BPA-treated rats. The frequency of inadequate responding (during the length of the delay) also provided a measure of restless behavior. Interestingly, the profile of BPA-treated males was feminized, strongly resembling that of control females. Animals were then tested (experiment 3) for the response to an amphetamine challenge (1 mg/kg, subcutaneously). The drug-induced increment activity was significantly less marked in BPA-treated male rats compared with controls. These findings provide clear indirect evidence of long-term alterations in brain monoaminergic function after perinatal BPA exposure. This may be a cause for concern for public health, confirming that exposure to a weak environmental estrogen in the period of sexual differentiation of the brain can influence adult behavior.

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Antidopaminergic Effect of Estrogens at the Striatal Level

Cited by 14 publications

References 4 publications

Gonadal Steroid Action on the Brain: Neurochemistry and Neuropharmacology

Gonadal Steroid Action on the Brain: Neurochemistry and Neuropharmacology

Sex-Dependent Antipsychotic Capacity of 17β-Estradiol in the Latent Inhibition Model: A Typical Antipsychotic Drug in Both Sexes, Atypical Antipsychotic Drug in Males

Altered profiles of spontaneous novelty seeking, impulsive behavior, and response to D-amphetamine in rats perinatally exposed to bisphenol A.

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