Antidiuretic Effects of ATP Induced by Microinjection into the Hypothalamic Supraoptic Nucleus in Water-Loaded and Ethanol-Anesthetized Rats

Mori, Mayumi; Tsushima, Hiromi; Matsuda, Takehisa

doi:10.1254/jjp.66.445

Cited by 16 publications

(5 citation statements)

References 23 publications

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“…ATP injected into the supraoptic nucleus of the hypothalamus has antidiuretic effects (Mori et al, 1994). Purinergic and adrenergic synergism for vasopressin and oxytocin release is consistent with ATP cotransmission in the hypothalamus (Kapoor and Sladek, 2000).…”

Section: A Neuroprotectionmentioning

confidence: 75%

Pathophysiology and Therapeutic Potential of Purinergic Signaling

2006

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Section: A Neuroprotectionmentioning

confidence: 75%

Pathophysiology and Therapeutic Potential of Purinergic Signaling

2006

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“…In addition to neuropeptides, MNC neurosecretory vesicles contain large amounts of ATP and MNCs express various P2X receptors , as well as P2Y receptors , providing further potential mechanisms for somato‐dendritic regulation of MNC activity . ATP injection into the SON induces anti‐diuresis in anaesthetised rats presumably via increased vasopressin secretion because ATP increases vasopressin (and oxytocin) secretion from hypothalamic explants . The ATP‐induced increase in hormone secretion likely arises from a direct ATP‐induced depolarisation of MNCs in combination with an ATP‐induced increase in glutamate and GABA release from presynaptic neurones .…”

Section: Somato‐dendritic Secretion From Mncsmentioning

confidence: 99%

Physiological Regulation of Magnocellular Neurosecretory Cell Activity: Integration of Intrinsic, Local and Afferent Mechanisms

Brown

Bains

Ludwig

et al. 2013

J Neuroendocrinology

142

133

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The hypothalamic supraoptic and paraventricular nucleus contain magnocellular neurosecretory cells (MNCs) that project to the posterior pituitary gland where they secrete either oxytocin or vasopressin (the anti-diuretic hormone) into the circulation. Oxytocin is important for delivery at birth and is essential for milk ejection during suckling. Vasopressin primarily promotes water reabsorption in the kidney to maintain body fluid balance, but also increases vasoconstriction. The profile of oxytocin and vasopressin secretion is principally determined by the pattern of action potentials initiated at the cell bodies. While it has long been known that the activity of MNCs depends upon afferent inputs that relay information on reproductive, osmotic and cardiovascular status, it has recently become clear that activity depends critically on local regulation by glial cells, as well as intrinsic regulation by the MNCs themselves. Here, we provide an overview of recent advances in our understanding of how intrinsic and local extrinsic mechanisms integrate with afferent inputs to generate appropriate physiological regulation of oxytocin and vasopressin MNC activity.

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“…Microinjection of ATP in PVN and SON causes VP release (Mori et al, 1992; Mori et al, 1994), indicating the presence of functional purinergic receptors on neuronal cell bodies. Moreover, caudal medulla neurons that project to VP neurons in SON release ATP as a cotransmitter with norepinephrine (Day et al, 1993).…”

Section: Purinergic Regulation Of the Hypothalamic-pituitary Unitmentioning

confidence: 99%

Purinergic signaling pathways in endocrine system

Bjelobaba

Janjic

Stojilković

2015

Autonomic Neuroscience

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Adenosine-5′-triphosphate is released by neuroendocrine, endocrine, and other cell types and acts as an extracellular agonist for ligand-gated P2X cationic channels and G protein-coupled P2Y receptors in numerous organs and tissues, including the endocrine system. The breakdown of ATP by ectonucleotidases not only terminates its extracellular messenger functions, but also provides a pathway for the generation of two additional agonists: adenosine 5′-diphosphate, acting via some P2Y receptors, and adenosine, a native agonist for G protein-coupled adenosine receptors, also expressed in the endocrine system. This article provides a review of purinergic signaling pathways in the hypothalamic magnocellular neurosecretory cells and neurohypophysis, hypothalamic parvocellular neuroendocrine system, adenohypophysis, and effector glands organized in five axes: hypothalamic-pituitary-gonadal, hypothalamic-pituitary-thyroid, hypothalamic-pituitary-adrenal, hypothalamic-pituitary-growth hormone, and hypothalamic-pituitary-prolactin. We attempted to summarize current knowledge of purinergic receptor subtypes expressed in the endocrine system, including their roles in intracellular signaling, hormone secretion, and other cell functions. We also briefly review the release mechanism for adenosine-5′-triphosphate by neuroendocrine, endocrine and surrounding cells, the enzymes involved in adenosine-5′-triphosphate hydrolysis to adenosine-5′-diphosphate and adenosine, and the relevance of this pathway for sequential activation of receptors and termination of signaling.

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Antidiuretic Effects of ATP Induced by Microinjection into the Hypothalamic Supraoptic Nucleus in Water-Loaded and Ethanol-Anesthetized Rats

Cited by 16 publications

References 23 publications

Pathophysiology and Therapeutic Potential of Purinergic Signaling

Pathophysiology and Therapeutic Potential of Purinergic Signaling

Physiological Regulation of Magnocellular Neurosecretory Cell Activity: Integration of Intrinsic, Local and Afferent Mechanisms

Purinergic signaling pathways in endocrine system

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