Antidiuretic Effect of 1-Propyl-3-p-chlorobenzene-sulfonylurea (Chlorpropamide)<sup>1</sup>

Membrives, J Reforzo; Moledo, Luis I.; Lanaro, Aldo E.; Megías, Alicia

doi:10.1210/jcem-28-3-332

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Cited by 37 publications

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“…Through the lens of ISNs, the balance between thirst vs. hunger would be expected to gravitate toward food consumption, as osmolality falls following pharmacological glucose lowering. In addition, sulfonylurea exhibits an antidiuretic effect, reducing free water clearance (8). The net result is relative hypoosmolality that could trigger an ISN-mediated orexigenic response.…”

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confidence: 99%