Antidiuretic Action of the Urine of Patients in Cardiac Failure

Bercu, Bernard A.; Rokaw, Stanley N.; Massie, Edward

doi:10.1161/01.cir.2.3.409

Cited by 62 publications

(9 citation statements)

References 28 publications

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“…In support of these hypotheses are the reported findings of an elevated amount of antidiuretic substances in the urine or blood of patients with such conditions. Elevated values have been reported in cirrhosis (10)(11)(12), congestive heart failure (13,14), hypertension (15), and Addison's disease (11). However, these substances are not the same in all instances, nor have they been shown conclusively to be identical with ADH (13), Perry and Fyles (16) found no correlation between levels of an antidiuretic substance and edema or liver damage, and no significant difference in antidiuretic activity between the sera of normals and patients with congestive failure or cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Studies on Alcohol Diuresis. Iii. The Response to Ethyl Alcohol in Certain Disease States Characterized by Impaired Water Tolerance 1

Lamdin¹,

Rubini²,

Epstein³

1956

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Studies on Alcohol Diuresis. Iii. The Response to Ethyl Alcohol in Certain Disease States Characterized by Impaired Water Tolerance 1

Lamdin¹,

Rubini²,

Epstein³

1956

J. Clin. Invest.

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“…The etiology of the altered fluid balance in CHF can be attributed to both hemodynamic (1,3,5,7) and hormonal factors (4,(8)(9)(10)(11). Evidence has been presented by several investigators that the secretion of antidiuretic hormone (ADH) may be altered during CHF or related disease states (12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

“…In addition to the modulation of ADH secretion, enhanced left atrial stretch receptor activity has been shown to depress renal efferent sympathetic nerve activity (55,56), an effect that would increase renal blood flow and glomerular filtration rate, thereby enhancing the ability of the kidney to reduce plasma volume. In spite of the potent stimulus on left atrial stretch receptors in CHF, ADH titers remain high and renal blood flow remains low (12,(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

The Mechanism of Adaptation of Left Atrial Stretch Receptors in Dogs with Chronic Congestive Heart Failure

Zucker

Earle²,

Gilmore³

1977

J. Clin. Invest.

163

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“…Brod and Fejfar (20) (38), cirrhosis (39), acute hepatitis (40), nephrotic edema (41), and hypertension (42). Although a diurnal variation in the secretion of ADH by the posterior pituitary could account for the nocturia in these conditions, it would fail to explain the changes in glomerular filtration rate and renal plasma flow.…”

Section: Discussionmentioning

confidence: 99%

Reversal of Diurnal Variation in Renal Function in Cases of Cirrhosis With Ascites 12

Jones¹,

McDonald²,

Last³

1952

J. Clin. Invest.

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The mechanism for control of diurnal rhythm of water and electrolyte excretion remains obscure, though the fact that such a cycle occurs was reported by Quincke (1) in 1877 who pointed out that urinary output was appreciably higher during the day in contrast to night. Campbell and Webster (2,3) observed that the excretion of chlorides and urea was also higher during the day, though creatinine excretion remained more or less at the same level. Subsequent studies (Table I) by Kleitman (4), Simpson (5, 6), Norn (7), Manchester (8), Gerritzen (9), Brod (10), and Sirota, Baldwin, and Villarreal (11) confirmed the observations that urine flow and excretion of certain electrolytes decreased during the hours of deepest sleep in normal individuals.This rhythm was not reversed when normal subjects slept in the daytime and took food and worked at night as reported by Campbell and Webster (2, 3), and confirmed in studies of a night watchman by Jores (12). Gerritzen (13) studied the effect of exposure of four subjects to artificial daylight during the night, and darkness during the day. In three subjects duplication of the rhythm in water and chloride excretion resulted, with two maxima occurring at noon and at midnight. In the fourth subject the rhythm was completely reversed. Borst and de Vries (14) have pointed out the difficulty in evaluating the effect of daylight and of waking on diurnal rhythm, though in some of their subjects the response to the stimulus of daylight was prompt. Jores (12) reported the relative difficulty in reversing a rhythm by a reversal of routine, and this was further supported by Joslings' (15) observation that a subject on a boat going from east to west showed a peak urinary excretion one hour earlier every day, the peak remaining at the same hour on local time. Addis and associates (16) reported nocturnal depression of endogenous creatinine clearances.On the basis of U/P inulin ratios and creatinine clearance data, Sirota, Baldwin, and Villarreal (11) attributed the decrease in urine flow during sleep almost wholly to water reabsorption. The mechanisms of increased tubular reabsorption of water at night were not elucidated and significant diurnal variations in effective renal plasma flow were not noted (11).Reports of a reversal of renal function (Table II) began with Wilson's (17) observation that the day and night rates of excretion of water and solids were approximately the same in the presence of debility, and especially so in cardiac or renal disease. Quincke (18) confirmed these observations several years later, noting that patients with heart or kidney disease often had a peak of ditiresis during the night. Fishberg (19) attributed the nocturnal increase in urine flow in patients with nephritis and congestive heart failure to decreased renal venous pressure and increased cardiac output in the prone position. Subsequent work by Brod and Fejfar (20) and by Baldwin, Sirota, and Villarreal (21), employing clearance techniques, revealed an increased glomerular filtration rate and decrea...

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Antidiuretic Action of the Urine of Patients in Cardiac Failure

Cited by 62 publications

References 28 publications

Studies on Alcohol Diuresis. Iii. The Response to Ethyl Alcohol in Certain Disease States Characterized by Impaired Water Tolerance 1

Studies on Alcohol Diuresis. Iii. The Response to Ethyl Alcohol in Certain Disease States Characterized by Impaired Water Tolerance 1

The Mechanism of Adaptation of Left Atrial Stretch Receptors in Dogs with Chronic Congestive Heart Failure

Reversal of Diurnal Variation in Renal Function in Cases of Cirrhosis With Ascites 12

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