Antidiarrhoeal activity of fractions of aqueous extract of Mangifera indica L. leaves in castor oil-induced diarrhoeal female Wistar rats

Salimon, Saoban S.; Yakubu, Musa Toyin

doi:10.4102/jomped.v4i1.88

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Medicinal plants have serve as source of therapeutic agents for the treatments of various ailments, some of which are without scientific credence to substantiate or refute such claims. The preliminary pharmacological screening of crude extracts of medicinal plants, which is a step towards the successful isolation of bioactive principles, will serve as lead for drug development and promote conservation and sustainability of ancient knowledge [23].…”

Section: Resultsmentioning

confidence: 99%

Spathodea companulata (African tulip tree) stem and root barks extracts ameliorated N-nitroso diethylamine induced hepatic impairment in male rats

Muhammed¹

2021

BIOMED nat. appl. sci.

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Spathodea campanulata Beauv. is an important plant widely used in traditional medicine for the treatment of hepatic disease. In the present study, we evaluate the phytochemical composition and hepatoprotective potential effect of the stem and root bark extracts of Spathodea companulata on dimethylnitrosamine (DEN) induced hepatic impairment in albino rats. Phytochemical compositions were analyzed using standard protocols. Forty-five male rats were grouped into 9 (A-I) of 5 rats each. Groups A-F were treated with stem bark extract, root bark extract, quercetin, DEN + stem bark extract, DEN + root bark extract, DEN + quercetin respectively while groups G-1 serve as control groups and were treated with corn oil only (Vehicle control), DEN only (Toxicant control), and distilled water (normal control) respectively. DEN was given at 25 mg/kg b.w., i.p on a weekly basis while all treatments were administered at 100 mg/kg BW orally for 60 days. Serum transaminase activities, body weight, and liver body weight ratio were evaluated. Results revealed the presence of alkaloids, cardiac glycoside, saponins, anthraquinone, steroids, and flavonoids in stem bark extract of Spathodea companulata, while the root bark contains cardiac glycoside, saponins, anthraquinonoid, steroids, and flavonoid. The DEN non-treated rat exhibited significant (p<0.05) weight loss and increase serum alanine transaminase (ALT) and aspartate transaminase (AST) activities when compared with the normal control. Treatment with stem and root bark extracts of Spathodea companulata significantly ameliorated the toxicant induce alterations in the transaminase activity and body weight loss when compared with the DEN nontreated rats. In conclusion, this study provides scientific validation of the use of this plant in traditional medicine for the management of hepatic disorders

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Section: Resultsmentioning

confidence: 99%

Spathodea companulata (African tulip tree) stem and root barks extracts ameliorated N-nitroso diethylamine induced hepatic impairment in male rats

Muhammed¹

2021

BIOMED nat. appl. sci.

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Hydroethanolic extract of Piliostigma thonningii leaves extenuates the severity of diarrhoea in female Wistar rats

Nurudeen,

Yusuf,

Salimon

et al. 2024

Journal of Complementary and Integrative Medicine

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Objectives Nigeria ranks second in the global prevalence of diarrhoea with most cases concentrated in the Northern-region of the country. This research explored the antidiarrhoeal efficacy of the hydroethanolic extract of Piliostigma thonningii leaves (HEPTL), locally used to manage diarrhoeal conditions in Kebbi State, Nigeria. Methods P. thonningii leaves were screened for their secondary metabolites and mineral constituents. Using 3 standard-diarrhoea models, female Wistar rats completely-randomised into six-groups of six animals each were utilised for probing the antidiarrhoeal activity of HEPTL. Animals in groups I and II served as the negative and positive controls, whereas the rats in groups III, IV and V respectively received 50, 100, and 200 mg/kg body weight-(bw) of HEPTL. Results Six secondary metabolites and eight minerals were found in the extract, with flavonoids and calcium being the most abundant while steroids and zinc were the least prevalent, respectively. High performance liquid chromatographic analysis revealed the presence of 19 bioactive substances. Furthermore, there was a significant (p<0.05) and dose-related reduction in diarrhoea onset, water content, and wet faeces count. Similarly, the amount of intestinal fluid and average distance traversed by the charcoal-meal were decreased dose-dependently by the HEPTL with a commensurate rise in the suppression of intestinal fluid accrual and peristalsis. Acetylcholinesterase, Na+/K+-ATPase, reduced glutathione, intestinal-alkaline phosphatase and protein levels increased significantly (p<0.05) whereas superoxide-dismutase, catalase, intestinal-nitric oxide and malondialdehyde levels all fell significantly (p<0.05). However, the level of intestinal glucose was not significantly altered. Conclusions Overall, the HEPTL exhibited a profound effect in the alleviation of the severity of diarrhoea, notably at 200 mg/kg bw.

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Antidiarrhoeal activity of fractions of aqueous extract of Mangifera indica L. leaves in castor oil-induced diarrhoeal female Wistar rats

Cited by 2 publications

References 13 publications

Spathodea companulata (African tulip tree) stem and root barks extracts ameliorated N-nitroso diethylamine induced hepatic impairment in male rats

Spathodea companulata (African tulip tree) stem and root barks extracts ameliorated N-nitroso diethylamine induced hepatic impairment in male rats

Hydroethanolic extract of Piliostigma thonningii leaves extenuates the severity of diarrhoea in female Wistar rats

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