Antidiarrhoeal activity of bisnordihydrotoxiferine isolated from the root bark of <i>Strychnos trinervis</i> (Vell.) Mart. (Loganiaceae)

Melo, M. De F. F.; Thomas, George P.; Mukherjee, Rabindranath

doi:10.1111/j.2042-7158.1988.tb05163.x

Cited by 22 publications

(12 citation statements)

References 9 publications

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“…The doses of the extracts of C. tamala (25, 50 and 100 mg/kg) were administered orally to different groups. The non-specific antidiarrhoeal reference drug diphenoxylate HCl (5 mg/kg) and physiological saline (10 mg/kg) were administered to two groups and later served as controls [4]. The total amount of faecal matter in each group was assessed every hour for the next 4 h. Percent reductions in the total amount of faeces in the treated groups were obtained by comparison with control animals.…”

Section: Effect On Normal Defecationmentioning

confidence: 99%

Antidiarrhoeal activity of the standardised extract of Cinnamomum tamala in experimental rats

et al. 2008

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The present study was designed to investigate the antidiarrhoeal potential of 50% ethanolic extract of Cinnamomum tamala on experimentally induced castor oil diarrhoea, gastric emptying of phenol red meal, gastrointestinal transit of charcoal meal and in vitro mast cell degranulation activity. C. tamala extract (25, 50 and 100 mg/kg, orally) produced a dose-dependent reduction in the total amount of faecal matter in castor oil-induced diarrhoea. The mean distance travelled by charcoal meal at 50 and 100 mg/kg of extract showed a significant reduction in the secretion of gastrointestinal fluid accumulation by 32.5-65.0%. The Na(+) and K(+) concentrations on castor oil-induced fluid accumulation showed a greater inhibitory effect on Na(+) levels than on K(+) concentrations. C. tamala significantly reduced the lipid peroxidation (P < 0.001) and increased the catalase (P < 0.01) activity in comparison to the castor oil-induced groups. C. tamala leaf extract did not show any significant effect at a higher dose (15 mg/ml) on mast cell degranulation. However, the extract in the dose of 5 and 10 mg/ml conferred significant mast cell protective action (P < 0.001). The percentage of eugenol in extract is 3.8% w/w, and total tannin is 247.5 mg/g. The result indicates the Indian spice C. tamala is useful for diarrhoea.

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Section: Effect On Normal Defecationmentioning

confidence: 99%

Antidiarrhoeal activity of the standardised extract of Cinnamomum tamala in experimental rats

et al. 2008

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“…Increasing doses (2.5 mg/kg and 5 mg/kg) of methanol extract of Albizzia lebbeck seeds were given intraperitoneally to different groups while one group served as a control (received normal saline). The number of faeces were counted every 2 h for the next 4 h. The percent reduction in the number of faeces in the treated groups was compared with the control (Melo et al, 1988).…”

Section: Intraluminal Fluid Accumulation In Ratmentioning

confidence: 99%

Antidiarrhoeal activity of seed extract of Albizzia lebbeck Benth.

Besra

Gomes

Chaudhury

et al. 2002

Phytotherapy Research

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The antidiarrhoeal activity of the seed extract of Albizzia lebbeck (Benth.) was investigated employing conventional rodent models of diarrhoea, i.e. castor oil-induced diarrhoea, upper gastrointestinal transit (u.g.t.) and fluid secretion. It was found that the aqueous methanol extract of Albizzia lebbeck seeds (2.5-5 mg/kg i.p.) possessed antidiarrhoeal activity which strengthens the earlier use of the seeds in the treatment of diarrhoea and dysentery. The antidiarrhoeal dose of the extract was at least 10-30 times less than the LD(50) dose. The extract (2.5-5 mg/kg i.p.) potentiated the antidiarrhoeal activity of loperamide (1 mg/kg i.p.). Nalaxone (0.5 mg/kg i.p.) significantly inhibited the antidiarrhoeal activity of the extract as well as loperamide, thus indicating a role of the opioid system in the antidiarrhoeal activity of the extract.

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“…Adult Wistar rats, weighing approximately 200 g each, were divided into groups of 12 animals each. Different doses of the decoction were given orally to every group, and 30 min later one of the following laxatives was administered: magnesium sulphate (Merck, Darmstadt, Germany) (1.8 g/kg) (de Melo et al, 1988) or sodium picosulphate (Boehringer Ingelheim, Barcelona, Spain) (5 mg/kg) (Capasso et al, 1986). The animals were placed in individual wire-bottomed cages over clean paper, which was changed 6, 9 and 24h after giving the product.…”

Section: Pharmacodynamic Assaysmentioning

confidence: 99%

Antidiarrhoeic activity of Sclerocarya birrea bark extract and its active tannin constituent in rats

Gálvez

Zarzuelo

Crespo

et al. 1991

Phytotherapy Research

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The antidiarrhoeic activity of the bark of Sclerocarya birrea was investigated. The lyophdized decoction demonstrated antidiarrhoeic activity in experimental models of diarrhoea induced by magnesium sulphate and sodium picosulphate. This antidiarrhoeic activity was related to an inhibition of intestinal transit rather than to inhibition of net secretion of fluid and electrolytes provoked by the laxative agents. A condensed tannin was isolated from the crude drug which produced inhibition in intestinal motility, and the monomer of which was identified as procyanidin.

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Antidiarrhoeal activity of bisnordihydrotoxiferine isolated from the root bark of Strychnos trinervis (Vell.) Mart. (Loganiaceae)

Cited by 22 publications

References 9 publications

Antidiarrhoeal activity of the standardised extract of Cinnamomum tamala in experimental rats

Antidiarrhoeal activity of the standardised extract of Cinnamomum tamala in experimental rats

Antidiarrhoeal activity of seed extract of Albizzia lebbeck Benth.

Antidiarrhoeic activity of Sclerocarya birrea bark extract and its active tannin constituent in rats

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