Antidiabetic property of <i><scp>A</scp>erva lanata</i> (<scp>L</scp>.) <scp>J</scp>uss. ex <scp>S</scp>chult. is mediated by inhibition of alpha glucosidase, protein glycation and stimulation of adipogenesis <i>软毛白花苋</i>(L.)的降糖特性是通过对α葡萄糖甙酶与蛋白质糖基化的抑制以及脂肪生成的刺激达成的

Riya, Mariam Philip; Antu, Kalathookunnel Antony; Pal, Subhashis; Chandrakanth, Karuvakandy Chandrasekharan; Anilkumar, K. S.; Tamrakar, Akhilesh K.; Srivastava, Arvind K.; Raghu, Kozhiparambil Gopalan

doi:10.1111/1753-0407.12216

Cited by 18 publications

(7 citation statements)

References 73 publications

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“…Our results for the contents of polyphenols and flavonoids in the AL herb are comparable to data reported previously by other authors [23][24][25]. There are some literature data about the antioxidant activity of polar extracts from A. lanata (L.) Juss.…”

Section: Optimisation Of Accelerated Solvent Extraction Conditionssupporting

confidence: 91%

LC-ESI-MS/MS Polyphenolic Profile and In Vitro Study of Cosmetic Potential of Aerva lanata (L.) Juss. Herb Extracts

et al. 2022

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The aim of the present study was to investigate the phenolic composition and the biological properties of different Aerva lanata (L). Juss. herb extracts obtained with the use of accelerated solvent extraction (ASE), i.e., a green, ecological method, for cosmetic purposes. All samples exhibited high DPPH• (9.17–119.85 mg TE/g) and ABTS•+ (9.90–107.58 mg TE/g) scavenging activity. The extracts exhibited considerable anti-lipoxygenase (EC50 between 1.14 mg/mL and 3.73 mg/mL) and anti-xanthine oxidase (EC50 between 1.28 mg/mL and 3.72 mg/mL) activities, moderate chelating activity (EC50 between 1.58 mg/mL and 5.30 mg/mL), and high antioxidant potential in the ORAC assay (0.36–3.84 mM TE/g). Changes in the polyphenol profile of the analysed samples depending on the solvent and temperature used for the extraction were determined with the liquid chromatography/electrospray mass spectrometry (LC-ESI-MS/MS) method. Twenty-one phenolic compounds, including flavonoids and phenolic acids, were detected and quantified. It was shown that tiliroside was one of the main phenolic metabolites in the A. lanata (L.) Juss. herb., which may suggest that this compound may be largely responsible for the observed anti-inflammatory activity of the extracts. In addition, the studied extracts exhibited promising skin-related (anti-tyrosinase, anti-elastase, anti-collagenase, and anti-hyaluronidase) activity. This study showed that Aerva lanata (L.) Juss. contains high amounts of phenolic compounds, including tiliroside, and has good skin-related activities. Therefore, the plant may be interesting as a novel source of bioactive agents for cosmetic industries.

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Section: Optimisation Of Accelerated Solvent Extraction Conditionssupporting

confidence: 91%

LC-ESI-MS/MS Polyphenolic Profile and In Vitro Study of Cosmetic Potential of Aerva lanata (L.) Juss. Herb Extracts

et al. 2022

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“…Additionally, in another study, ethanolic extract and ethyl acetate extract caused inhibition of yeast α-glucosidase (IC 50 = 81.76 µg/mL and 108.23 µg/mL, respectively). Both extracts also inhibited rat intestinal α-glucosidase (IC 50 value of ethanolic extract and ethyl acetate extract: 108.7 and 208.04 µg/mL, respectively) [23].…”

Section: Anti-diabetic Activitymentioning

confidence: 92%

“…Additionally, the anti-diabetic potential of A. lanata (L.) Juss. root extracts related to inhibition of enzymes has been recently reported [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Anti-Diabetic Activity of Phenolic Acids Fractions Obtained from Aerva lanata (L.) Juss.

et al. 2021

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Many plants that are commonly used in folk medicine have multidirectional biological properties confirmed by scientific research. One of them is Aerva lanata (L.) Juss. (F. Amaranthaceae). It is widely used, but there are very few scientific data about its chemical composition and pharmacological activity. The aim of the present study was to investigate the chemical composition of phenolic acid (PA)-rich fractions isolated from methanolic extracts of A. lanata (L.) Juss. herb using the liquid/liquid extraction method and their potential antioxidant, anti-inflammatory, and anti-diabetic properties. The free PA fraction (FA), the PA fraction (FB) released after acid hydrolysis, and the PA fraction (FC) obtained after alkaline hydrolysis were analysed using liquid chromatography/electrospray ionization triple quadrupole mass spectrometry (LC-ESI-MS/MS). The phenolic profile of each sample showed a high concentration of PAs and their presence in A. lanata (L.) Juss. herb mainly in bound states. Thirteen compounds were detected and quantified in all samples, including some PAs that had not been previously detected in this plant species. Bioactivity assays of all fractions revealed high 2,2-diphenyl-1-picrylhydrazyl (DPPH•) (2.85 mM Trolox equivalents (TE)/g) and 2,2-azino-bis-3(ethylbenzthiazoline-6-sulphonic acid) (ABTS•+) (2.88 mM TE/g) scavenging activity. Fraction FB definitely exhibited not only the highest antiradical activity but also the strongest xanthine oxidase (XO) (EC50 = 1.77 mg/mL) and lipoxygenase (LOX)(EC50 = 1.88 mg/mL) inhibitory potential. The fraction had the best anti-diabetic properties, i.e., mild inhibition of α-amylase (EC50 = 7.46 mg/mL) and strong inhibition of α-glucosidase (EC50 = 0.30 mg/mL). The activities of all analysed samples were strongly related to the presence of PA compounds and the total PA content.

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“…La medicina tradicional realizó una buena práctica clínica y está mostrando un futuro brillante en la terapia de la DM 2. Hay que señalar que muchas drogas están disponibles para controlar nivel de glucosa en sangre presenta efectos secundarios graves (Currie et al 2009;Mukherjee et al 2006;Subramonian 2017), mientras que, para el caso de las plantas son una buena fuente de medicamentos antidiabéticos con menos efectos secundarios (Riya et al 2015;Venkatesh et al 2003) y además son de bajo costo (Sunmonu y Afolayan 2013), es por ello que representa una gran alternativa emplear plantas medicinales tradiconales en el control de la enfermedad (Suba et al, 2004) En relación a los reportes sobre plantas con propiedades hipoglucemiante, entre estos: Rani et al 2017; Marles and Farnsworth, 1995;Oyagbemi et al 2014;Maharjan y Nampoothiri 2015; Brazilian Journal of Animal and Environmental Research, Curitiba, v.4, n.4, p. 4925-4943 out./dez.. 2021. Herrera et al, 2011;Salem et al 2017;Palma-Tenango et al 2017;Mueller and Mechler 2005;Alvez da Rocha et al 2013;Govea-Salas et al 2017;Aguilar y Xolalpa, 1998;entre otros. Al respecto nuestro país posee una tradición milenaria en el conocimiento y empleo de las plantas, aunque a la llegada de los españoles en el siglo XVI el conocimiento fue subestimado, sin embargo, día a día hay un aumento de información en la etnobotánica, taxonómica o fitoquímica.…”

Section: Introductionunclassified

Recursos herbolarios empleados en el control de la glucosa en pacientes con diabetes mellitus 2 en la cienega de chapala, michoacan. Un reencuentro con la tradición / Herbal resources used in the control of Glucose in patients with diabetes mellitus 2, in cienega de chapala, michoacan. A reunion with tradition

Ruiz¹,

Ocaña²

2021

Braz. J. Anim. Environ. Res.

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La Diabetes Mellitus es una enfermedad metabólica crónica multifactorial que representa en la actualidad un problema de salud pública en el mundo y en México. El tratamiento de la diabetes con drogas sintéticas en países en desarrollo es costoso agregando a ello la falta de acceso a medicamentos; por lo que la fitoterapia representa una alternativa segura, de alta disponibilidad y bajo costo en estos. Nuestro país posee una tradición ancestral en el conocimiento y uso de plantas medicinales que puede ser explotado para el control de este padecimiento además de preservar la tradición en uso de recursos herbolarios. El objetivo del estudio fue identificar las especies botánicas empleadas en el control de la diabetes en la región de la Ciénega de Chapala, Michoacán. Se obtuvo la recopilación de 28 especies tanto nativas como introducidas; sin embargo, existen plantas documentadas con potencial hipoglucemiante que en la región desconocen.

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Antidiabetic property of Aerva lanata (L.) Juss. ex Schult. is mediated by inhibition of alpha glucosidase, protein glycation and stimulation of adipogenesis 软毛白花苋(L.)的降糖特性是通过对α葡萄糖甙酶与蛋白质糖基化的抑制以及脂肪生成的刺激达成的

Abstract: Alpha glucosidase inhibition, antiglycation, and adipogenic potential significantly contribute to the antidiabetic property of Aerva lanata. In addition, insulin sensitization and antioxidant potential also enhance its therapeutic potential.

Cited by 18 publications

References 73 publications

LC-ESI-MS/MS Polyphenolic Profile and In Vitro Study of Cosmetic Potential of Aerva lanata (L.) Juss. Herb Extracts

LC-ESI-MS/MS Polyphenolic Profile and In Vitro Study of Cosmetic Potential of Aerva lanata (L.) Juss. Herb Extracts

Antioxidant, Anti-Inflammatory, and Anti-Diabetic Activity of Phenolic Acids Fractions Obtained from Aerva lanata (L.) Juss.

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