Antidiabetic Properties of Dietary Chrysin: A Cellular Mechanism Review

Abstract

: Diabetes mellitus is the most common chronic metabolic disorder and is considered one of the leading causes of morbidity and mortality. The improperly-treated chronic hyperglycemia of diabetes has been related to several long-term complications and multiple organ failures, including nephropathy, which can lead to kidney failure, retinopathy with the potential loss of vision, and cardiovascular symptoms. Current commercially available synthetic glucose-lowering agents have been reported to have several adverse effects. Therefore, the search for alternative remedies such as medicinal plants and their active compounds have attracted attention. Chrysin is an active flavonoid that exists widely in various plants and diets and has been reported to possess pharmacological properties, including antidiabetic activity. Many studies have been conducted to characterize the antidiabetic of chrysin, as well as its potential pathways, in in vitro and in vivo experiments. Chrysin has shown promise as an antidiabetic agent in animal studies, thus, demonstrating its potential to be developed as an antidiabetic drug. This review discussed the antidiabetic action of chrysin and its mechanisms, including targeting different mechanisms such as stimulation of insulin signaling, blockage of endoplasmic reticulum stress and oxidative damage, promotion of skeletal glucose uptake, as well as modulation of apoptosis and autophagy signaling. Additionally, this review would be useful for further studies regarding the mechanism of work of plant derived-compound as a potential antidiabetic agent.

Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals

“…Chrysin, isolated from various plants such as the blue passion flower ( Passiflora caerulea L.), is a flavonoid compound with a variety of pharmacological activities including antidiabetic, anti-inflammatory, and antitumor activities [ 114 , 115 , 116 ]. Sa et al, reported a novel salt cocrystal of chrysin (ChrH) and berberine (BerbOH) [ 71 ], which is also a new drug−drug cocrystal based on two natural products.…”

Baicalein targets STMN1 to inhibit the progression of nasopharyngeal carcinoma via regulating the Wnt/β‐catenin pathway

“…Baicalein is a bioactive flavonoid in the dried roots of Scutellaria baicalensis Georgi 8 . Its biological activities have been reported in previous studies, including antithrombotic, antibacterial, anti‐inflammation, antiviral, antidiabetic, and anticancer activities 9–15 . Moreover, baicalein restrained the development of various malignancies via multiple cellular signaling pathways.…”

“…8 Its biological activities have been reported in previous studies, including antithrombotic, antibacterial, anti-inflammation, antiviral, antidiabetic, and anticancer activities. [9][10][11][12][13][14][15] Moreover, baicalein restrained the development of various malignancies via multiple cellular signaling pathways. Previous studies indicated that baicalein triggered cell apoptosis and hampered cell growth in osteosarcoma through regulating the Wnt/β-catenin pathway, 16 in prostate cancer through the AKT/mTOR pathway, 17 in gastric cancer through mediating the FAK/AKT pathway, 18 and in colorectal cancer through modulating the PI3K/AKT pathway.…”

Chrysin Attenuates Oxidative Stress to Alleviate Sevoflurane-Induced Cognitive Impairments in Aged Rats

“…Chrysin (5,7-dihydroxy flavones) is a naturally-occurring flavone found in flowers, honey, mushrooms, and propolis [ 11 ]. The anxiolytic [ 12 ], antioxidant [ 13 ], antidiabetogenic [ 14 ], anti-cancer [ 15 ], and antiestrogenic [ 16 ] properties of chrysin have been reported. For example, antiaging effect of chrysin has been investigated in d-galactose-induced aging model in rats [ 13 ].…”