Antidiabetic potential of purple okra (<i>Abelmoschus esculentus</i> L.) extract in streptozotocin-induced diabetic rats

Anjani, Putri Puncak; Damayanthi, Evy; Rimbawan, Rimbawan; Handharyani, Ekowati

doi:10.1088/1755-1315/196/1/012038

Cited by 14 publications

(19 citation statements)

References 34 publications

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“…Both extracts did not have significant effect in rats' body weight, but they could usefully repair destructed pancreas β cells caused by STZ induction. These results show that purple and green okra extracts have antidiabetic potential (Anjani et al, 2018).…”

Section: Effect Of Okra On Diabetesmentioning

confidence: 69%

“…It is associated with considerable morbidity and mortality (WHO, 2016). Different studies have shown that A. esculentus has antidiabetic effects (Anjani, Damayanthi, Rimbawan, & Handharyani, 2018; via different mechanisms including lowering glucose absorption from intestinal tract (Khatun, Rahman, Biswas, & Islam, 2011), inhibition of DPP-4 activity (Huang, Wang, Lee, & Peng, 2017)…”

Section: Effect Of Okra On Diabetesmentioning

confidence: 99%

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Effect of Abelmoschus esculentus (okra) on metabolic syndrome: A review

Esmaeilzadeh

Razavi

Hosseinzadeh

2020

Phytotherapy Research

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Metabolic syndrome is a disorder characterized by dyslipidemia, insulin resistance, abdominal fat, high blood pressure, hypertriglyceridemia, and diminished high density lipoprotein cholesterol. Okra (Abelmoschus esculentus L.), routinely called lady's finger, has belonged to the Malvaceae family. Okra is considered as a valuable crop due to the multiple functions of its leaves, buds, flowers, pods, stems, and seeds in traditional and modern medicines. Several bioactive components are presented in different parts of okra including polyphenolic compounds especially oligomeric catechins and flavonol derivatives such as quercetin. The antioxidant, anti‐inflammatory, anticancer, immunomodulatory, gastroprotective, neuroprotective, lipid lowering, and antidiabetic effects of okra have been established. Although different in vivo and in vitro studies revealed that okra has an ability to overcome metabolic syndrome symptoms, the lack of clinical studies is notable. So, further clinical trials should be accomplished to confirm the role of okra in metabolic syndrome. The aims of this review are to gather different studies regarding the potential efficacy of okra in metabolic syndrome.

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Section: Effect Of Okra On Diabetesmentioning

confidence: 69%

Section: Effect Of Okra On Diabetesmentioning

confidence: 99%

Effect of Abelmoschus esculentus (okra) on metabolic syndrome: A review

Esmaeilzadeh

Razavi

Hosseinzadeh

2020

Phytotherapy Research

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“…Specifically, red okra pods have added xenobioticsidants (anthocyanin) responsible for the pods' red color [21]. Extracts from purple okra contain anthocyanin with higher antioxidant and quercetin content than the green okra; hence, plants containing anthocyanin are more effective than the plant devoid of the compound [22]. Okra is a popular vegetable crop with good nutritional significance and specific therapeutic values, making it a potential candidate for the use of a variety of nutraceuticals and affordable medicines.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Red Okra (Abelmoschus esculentus (L.) Moench) Pods against Sodium Nitrite-Induced Liver Injury in Mice

Wahyuningsih

Mwendolwa²,

Winarni

et al. 2021

Veterinary Medicine International

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Vegetables, drinking water, and preserved meats may contain sodium nitrite (NaNO2), which causes liver disease by inducing oxidative stress. Phytochemicals are highly recommended as an alternative to synthetic drugs and affordable medicines to treat liver disease because they have fewer or no side effects. Therefore, this study aims to determine the antioxidant and hepatoprotective potential of red okra fruit ethanol extract against NaNO2-induced liver damage. Thirty-six male mice were separated into six groups. The normal control group (WA) was given distilled water only, and the NaNO2 (SN) group was given only 50 mg/kg BW NaNO2. The other four groups (P1, P2, P3, and P4) were given NaNO2 and red okra ethanol extract at doses of 25, 50, 75, and 100 mg/kg BW, respectively. Gavage was administered orally for 21 consecutive days. Commercial kits define all biochemical parameters according to the manufacturer’s instructions. Liver tissue staining followed standard protocols using hematoxylin and eosin. The study revealed that NaNO2 induction causes oxidative stress and damages the liver. The activity of antioxidant enzymes (superoxide dismutase and catalase) significantly increased in the groups treated (P2–P4) with ethanol extract of red okra ( p < 0.05 ). Besides, the oxidants (malondialdehyde, F2-isoprostanes, and nitric oxide) in the liver homogenate significantly decreased in the P4 group, which were given red okra ethanol extract ( p < 0.05 ). Likewise, red okra pods decreased significantly for the serum biochemical parameters of liver damage (aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferase) in the P3 and P4 groups ( p < 0.05 ). Then, it led to a restoration of the histological structure compared to exposed mice (SN), as the pathological scores decreased significantly in the P3 and P4 groups ( p < 0.05 ), as well as the number of the necrotic and swollen liver cells was reduced. Hepatocytes returned to normal. The results showed that the ethanol extract of red okra fruit could be helpful as an affordable medicine. It is an antioxidant and hepatoprotective agent to protect the liver from damage caused by NaNO2.

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“…Quantitatively, okra fruit extracts has a total flavonoid and quercetin content higher from green okra extract of 27.0 mg/100 g and 20.03 mg (QE)/100 g [49,50]. The green okra fruits contain of flavonoid such as a quercetin derivative.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Alginate from Sargassum duplicatum and the Antioxidant Effect of Alginate–Okra Fruit Extracts Combination for Wound Healing on Diabetic Mice

et al. 2020

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Diabetes mellitus is a group of metabolic disorders characterized by high blood-glucose levels over a prolonged period that causes complications when an open wound is present. Alginate is an antioxidant and a good absorbent of exudates. Okra fruit contains flavonoids that can act as antioxidants. The antioxidant properties of extracts combination reduce blood-glucose levels significantly to accelerate the activities of wound-healing processes on diabetic mice. Alginate was characterized by Size Exclusion Chromatography-Multiple Angle Laser Light Scattering (SEC-MALLS), thermal stability and Proton Nuclear Magnetic Resonance (1H-NMR). The evaluation of wound healing on 36 male mice were divided into 12 groups including normal control (NC), diabetics control (DC), alginate (DA) and alginate–okra (DAO) groups in three different times by histopathology test on skin tissue. The results of SEC-MALLS analysis showed that alginate as single and homogeneous polysaccharide. The 1H-NMR spectrum showed that the mannuronate/guluronate ratio of the used alginate was 0.91. Alginate, okra fruit extract and their combination were classified as moderate and strong antioxidants. The numbers of fibrocytes, fibroblasts, collagen densities had significantly increased from three to seven days. In contrast, wound width, neutrophil, macrophages had significantly decreased at 14 days. The administration of extracts combination increased the re-epithelization of the wound area and wound-healing process on diabetic mice.

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Antidiabetic potential of purple okra (Abelmoschus esculentus L.) extract in streptozotocin-induced diabetic rats

Cited by 14 publications

References 34 publications

Effect of Abelmoschus esculentus (okra) on metabolic syndrome: A review

Effect of Abelmoschus esculentus (okra) on metabolic syndrome: A review

Protective Effect of Red Okra (Abelmoschus esculentus (L.) Moench) Pods against Sodium Nitrite-Induced Liver Injury in Mice

Characterization of Alginate from Sargassum duplicatum and the Antioxidant Effect of Alginate–Okra Fruit Extracts Combination for Wound Healing on Diabetic Mice

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