Antidiabetic herbal medicines rebranded as dietary supplements

Habtemariam, Solomon

doi:10.1016/b978-0-08-102922-0.00026-2

Cited by 4 publications

(1 citation statement)

References 388 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…En general la mayoría de las publicaciones que han evaluado el efecto de los compuestos bioactivos provenientes de cactáceas sobre los altos niveles de glucosa en sangre, están basados en el estudio de tallos o clados (Habtemariam, 2019). Andrade-Cetto (2012) se concluye que el efecto anti-hiperglucemiante que presento la especie Opuntia streptacantha sobre ratas diabetizadas no está asociado con la inhibición de la enzima alfa-glicosidasa o debido a la hidrolisis intestinal de los disacáridos.…”

Section: Efecto Anti-hiperglucemianteunclassified

Obtención de betalaínas en variantes de Stenocereus stellatus y su encapsulación en coacervados complejos

Arista

View full text Add to dashboard Cite

show abstract

Section: Efecto Anti-hiperglucemianteunclassified

Obtención de betalaínas en variantes de Stenocereus stellatus y su encapsulación en coacervados complejos

Arista

View full text Add to dashboard Cite

show abstract

Screening of plant-based natural compounds as a potential COVID-19 main protease inhibitor: anin silicodocking and molecular dynamics simulation approach

Majumder

Mandal

2020

Journal of Biomolecular Structure and Dynamics

View full text Add to dashboard Cite

A new strain of coronavirus (CoV) has been identified as SARS-CoV-2, which is responsible for the recent COVID-19 pandemic. Currently, there is no approved vaccine or drug available to combat the pandemic. COVID-19 main protease (M pro) is a key CoV enzyme, which plays an important role in triggering viral replication and transcription, turns it into an attractive target. Therefore, we aim to screen natural products library to find out potential COVID-19 M pro inhibitors. Plant-based natural compounds from Sigma-Aldrich plant profiler chemical library have been screened through virtual molecular docking and molecular dynamics simulation to identify potential inhibitors of COVID M pro. Our virtual molecular docking results have shown that there are twenty-eight natural compounds with a greater binding affinity toward the COVID-19 M pro inhibition site as compared to the co-crystal native ligand Inhibitor N3 (-7.9 kcal/mol). Also, molecular dynamics simulation results have confirmed that Peonidin 3-O-glucoside, Kaempferol 3-Ob-rutinoside, 4-(3,4-Dihydroxyphenyl)-7-methoxy-5-[(6-O-b-D-xylopyranosyl-b-D-glucopyranosyl)oxy]-2H-1benzopyran-2-one, Quercetin-3-D-xyloside, and Quercetin 3-O-a-L-arabinopyranoside (selected based on the docking score) possess a significant amount of dynamic properties such as stability, flexibility and binding energy. Our In silco results suggests that all the above mention natural compounds have the potential to be developed as a COVID-19 M pro inhibitor. But before that, it must go through under the proper preclinical and clinical trials for further scientific validation.

show abstract

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

Habtemariam

2020

Biomedicines

View full text Add to dashboard Cite

Berberine is a quaternary isoquinoline alkaloid that has been isolated from numerous plants which are still in use today as medicine and herbal supplements. The great deal of enthusiasm for intense research on berberine to date is based on its diverse pharmacological effects via action on multiple biological targets. Its poor bioavailability resulting from low intestinal absorption coupled with its efflux by the action of P-glycoprotein is, however, the major limitation. In this communication, the chemical approach of improving berberine’s bioavailability and pharmacological efficacy is scrutinised with specific reference to type-2 diabetes and associated diseases such as hyperlipidaemia and obesity. The application of modern delivery systems, research from combination studies to preparation of berberine structural hybrids with known biologically active compounds (antidiabetic, antihyperlipidaemic and antioxidant), as well as synthesis approaches of berberine derivative are presented. Improvement of bioavailability and efficacy through in vitro and ex vivo transport studies, as well as animal models of bioavailability/efficacy in lipid metabolism and diabetes targets are discussed.

show abstract

Antidiabetic herbal medicines rebranded as dietary supplements

Cited by 4 publications

References 388 publications

Obtención de betalaínas en variantes de Stenocereus stellatus y su encapsulación en coacervados complejos

Obtención de betalaínas en variantes de Stenocereus stellatus y su encapsulación en coacervados complejos

Screening of plant-based natural compounds as a potential COVID-19 main protease inhibitor: anin silicodocking and molecular dynamics simulation approach

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

Contact Info

Product

Resources

About