Antidiabetic Effects of Pterosin A, a Small-Molecular-Weight Natural Product, on Diabetic Mouse Models

Hsu, Feng‐Lin; Huang, Chun-Fa; Chen, Yawen; Yen, Yuan-Peng; Wu, Cheng-Tien; Uang, Biing‐Jiun; Yang, Rong‐Sen; Liu, Shing‐Hwa

doi:10.2337/db12-0585

Cited by 69 publications

(37 citation statements)

References 49 publications

(51 reference statements)

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“…The effect of Sal B on GLUT4 is consistent with the decrease in fasting blood glucose and the improvement in glucose tolerance and insulin tolerance in Sal B treated diabetic mice. As one of rate-limiting enzymes in glycogen synthesis, glycogen synthase is also a downstream target of AMPK [21]. Our results shown that glycogen synthase protein expression in skeletal muscle was enhanced by Sal B compared to the control mice.…”

Section: Discussionmentioning

confidence: 50%

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Salvianolic Acid B Ameliorates Hyperglycemia and Dyslipidemia in db/db Mice through the AMPK Pathway

Huang

Zhou

Zhang

et al. 2016

Cell Physiol Biochem

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Background/Aims: Salvianolic acid B (Sal B), a major polyphenolic compound of Salvia miltiorrhiza Bunge, has been shown to possess potential antidiabetic activities. However, the action mechanism of SalB in type 2 diabetes has not been investigated extensively. The present study was designed to investigate the effects of Sal B on diabetes-related metabolic changes in a spontaneous model of type 2 diabetes, as well as its potential molecular mechanism. Methods: Male C57BL/KsJ-db/db mice were orally treated with Sal B (50 and 100 mg/kg) or metformin (positive drug, 300 mg/kg) for 6 weeks. Results: Both doses of Sal B significantly decreased fasting blood glucose, serum insulin, triglyceride and free fatty acid levels, reduced hepatic gluconeogenic gene expression and improved insulin intolerance in db/db mice. High dose Sal B also significantly improved glucose intolerance, increased hepatic glycolytic gene expression and muscle glycogen content, and ameliorated histopathological alterations of pancreas, similar to metformin. Sal B treatment resulted in increased phosphorylated AMP-activated protein kinase (p-AMPK) protein expression in skeletal muscle and liver, increased glucose transporter 4 (GLUT4) and glycogen synthase protein expressions in skeletal muscle, and increased peroxisome proliferator-activated receptor alpha (PPARα) and phosphorylated acetyl CoA carboxylase (p-ACC) protein expressions in liver. Conclusion: Our data suggest that Sal B displays beneficial effects in the prevention and treatment of type 2 diabetes at least in part via modulation of the AMPK pathway.

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Section: Discussionmentioning

confidence: 50%

“…To our knowledge, no study has assessed Sal B effects on C57BL/KsJ-db/db mice, an spontaneous animal model similar to human type 2 diabetes [21]. In this model, diabetesrelated metabolic changes including hyperglycemia, hyperinsulinemia, glucose intolerance, and insulin resistance can be maintained [22,23].…”

Section: Introductionmentioning

confidence: 99%

Salvianolic Acid B Ameliorates Hyperglycemia and Dyslipidemia in db/db Mice through the AMPK Pathway

Huang

Zhou

Zhang

et al. 2016

Cell Physiol Biochem

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“…The FMD cycles also reversed the decline in insulin secretion at d30 and improved plasma insulin levels at day 90 (Figure 1C). A Homeostasis Model Assessment (HOMA) was performed to estimate steady state β-cell function (%B) and insulin sensitivity (%S), as previously described (Hsu et al, 2013; Matthews et al, 1985). The results indicate that the reversal of hyperglycemia was mainly caused by an induction of steady state β-cell function (%B) in addition to the minor alleviation of insulin resistance (HOMA-IR) (Figure 1D).…”

Section: Resultsmentioning

confidence: 99%

Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes

Cheng

Villani

Buono

et al. 2017

Cell

286

240

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Summary Stem cell-based therapies can potentially reverse organ dysfunction and diseases but the removal of impaired tissue and reactivation of the program leading to organ regeneration pose major challenges. In mice, a four-day fasting mimicking diet (FMD) induces a step-wise expression of Sox17 and Pdx-1, resembling that observed during pancreatic development, followed by Ngn3-driven generation of insulin-producing β-cells. FMD cycles restore insulin secretion and glucose homeostasis in both a type 2 and type 1 diabetes mouse models. In human type 1 diabetes pancreatic islets, fasting conditions reduce PKA and mTOR activity and induce Sox2 and Ngn3 expression and insulin production. The effects of the FMD are reversed by IGF-1 treatment and recapitulated by PKA and mTOR inhibition. These results indicate that a FMD promotes the reprogramming of pancreatic cells to restore insulin generation in islets from T1D patients and reverse both T1D and T2D phenotypes in mouse models.

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“…Many related metabolic proteins were involved in the diabetic hyperglycemia, including AMP Kinase (AMPK), GLUT 4, PEPCK, acetyl CoA carboxylase, glycogen synthase kinase-3, and glycogen synthase [30]. Among them, GLUT 4 and PEPCK were commonly used to investigate diabetic disorders [31], and plasma glucose-lowering activities of some agents were associated with an increase in the glucose utilization in peripheral tissues and a reduction in hepatic gluconeogenesis [19, 32].…”

Section: Discussionmentioning

confidence: 99%

Decrease of Plasma Glucose byHibiscus taiwanensisin Type-1-Like Diabetic Rats

Wang

Chung

Cheng

2013

Evidence-Based Complementary and Alternative Medicine

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Hibiscus taiwanensis (Malvaceae) is widely used as an alternative herb to treat disorders in Taiwan. In the present study, it is used to screen the effect on diabetic hyperglycemia in streptozotocin-induced diabetic rats (STZ-diabetic rats). The extract of Hibiscus taiwanensis showed a significant plasma glucose-lowering action in STZ-diabetic rats. Stems of Hibiscus taiwanensis are more effective than other parts to decrease the plasma glucose in a dose-dependent manner. Oral administration of Hibiscus taiwanensis three times daily for 3 days into STZ-diabetic rats increased the sensitivity to exogenous insulin showing an increase in insulin sensitivity. Moreover, similar repeated administration of Hibiscus taiwanensis for 3 days in STZ-diabetic rats produced a marked reduction of phosphoenolpyruvate carboxykinase (PEPCK) expression in liver and an increased expression of glucose transporter subtype 4 (GLUT 4) in skeletal muscle. Taken together, our results suggest that Hibiscus taiwanensis has the ability to lower plasma glucose through an increase in glucose utilization via elevation of skeletal GLUT 4 and decrease of hepatic PEPCK in STZ-diabetic rats.

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Antidiabetic Effects of Pterosin A, a Small-Molecular-Weight Natural Product, on Diabetic Mouse Models

Cited by 69 publications

References 49 publications

Salvianolic Acid B Ameliorates Hyperglycemia and Dyslipidemia in db/db Mice through the AMPK Pathway

Salvianolic Acid B Ameliorates Hyperglycemia and Dyslipidemia in db/db Mice through the AMPK Pathway

Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes

Decrease of Plasma Glucose byHibiscus taiwanensisin Type-1-Like Diabetic Rats

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