Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency

Joseph, Baby; Jini, D.

doi:10.1016/s2222-1808(13)60052-3

Cited by 379 publications

(299 citation statements)

References 63 publications

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“…Importantly, many Amerindian disease descriptions closely correspond those in Western allopathic medicine, and the treatments are often successful [54]. An example is the indigenous use of the dried leaves of the bitter gourd Momordica charantia L. (Cucurbitacea) ( Figure 6) for treating the symptoms of diabetes mellitus, which is supported by the hypoglycemic effects of M. charantia preparations in various animal models [55].…”

Section: Use Of Traditional Medicinesmentioning

confidence: 94%

“…These sources report, for instance, on the generally acknowledged Amerindian use of the dried leaves from the bitter melon M. charantia against the symptoms of diabetes mellitus [55]; the Afro-Surinamese use of Q. amara for treating malaria fever [77]; the Hindustani use of the leaves from the neem plant A. indica to boost the immune system [62]; and the Javanese use of the leaves from the cat's whiskers Orthosiphon aristatus (Blume) Miq. (Lamiaceae) for treating kidney stones and renal colics [78].…”

Section: Research On Medical Plants In Suriname Plant Selectionmentioning

confidence: 99%

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“Nature, green in leaf and stem”. Research on plants with medicinal properties in Suriname

Mans¹

2017

Clin Med Invest

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The widely held layman's perception of nature as a collection of animals operating against a static green background of plants is a serious misunderstanding of the complexity and dynamics of the plant biodiversity. Plants fulfill all functions that superficially only seem reserved for animals including movement, communication, and defense. For the latter purposes, plants have developed intricate and highly sophisticated chemical warning signals and defense systems to alarm friends and ward off foes. Many of these plant substances possess meaningful pharmacological properties, and some were found useful against human diseases. This paper briefly describes several aspects of plant communication and defense; gives a few examples of plant-derived therapeutics; and focuses on the potential contribution of Suriname (South America) to this scientific area.

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Section: Use Of Traditional Medicinesmentioning

confidence: 94%

Section: Research On Medical Plants In Suriname Plant Selectionmentioning

confidence: 99%

“Nature, green in leaf and stem”. Research on plants with medicinal properties in Suriname

Mans¹

2017

Clin Med Invest

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“…Momordica charantia [50], Nervilia plicata [51], Gymnema sylvestre, Ficus religiosa, Eugenia jambolana, Allium sativum, Pterocarpus marcupium, and Ocimum sanctum are a few [52,53]. Gymnema sylvestre is known to have high antidiabetic activity.…”

Section: Plants With Hypoglycemic or Anti-hyperglycemic Activitymentioning

confidence: 99%

Therapeutic Potential of Plant Phenolics for the Management of Diabetic Retinopathy

Pandita¹,

Vaidya²

2014

TOPHARMCJ

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Diabetes is a systemic disease affecting a large proportion of the population worldwide. Hyperglycemia, the major factor responsible for its development, is known to cause both microvascular and macrovascular complications if not controlled in time. Retinopathy is one such microvascular complication of the eye and has been studied extensively. There are biochemical pathways that lead to its progression and are common to other complications, viz. the formation of advanced glycation end products, the activation of protein kinase C, increase in oxidative stress and the polyol pathway. Though there are standard treatments available to manage diabetic retinopathy, there remains a need to explore herbal medicine as an alternative for its treatment. Many herbal preparations alleviating hyperglycemia that are used to treat diabetes or have insulin sensitizing effects are available in the market. These may help managing diabetic retinopathy, too. Many plants are known to produce inhibitors of advanced glycation end products, the aldose reductase (polyol) pathway, and protein kinase C (PKC). Hence, there is a necessity to evaluate the potential of these plants, focussing on individual phytoconstituents like phenolic compounds.

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“…In addition, it also contains polyphenolic compounds (flavonoids, coumarins, anthroquinones, anthocyanin, carotenoid, gentisic acid, gallic acid, catechin and caffeic acid) (Kubola and Siriamornpun 2008;Horax et al 2010;Nagarani et al 2014), saponins, alkaloids, proteins and steroids (Grover and Yadav 2004). Bitter gourd has been used for the treatment of diabetes, gout, jaundice, rheumatism and pneumonia (Joseph and Jini 2013), and possesses other medicinal properties, such as anti-tumor and anti-mutagenic activities (Anilakumar et al 2015). Even though bitter gourd is very good for health, most people avoid consuming it because of its bitter taste (Paul and Raychaudhuri 2010).…”

Section: Introductionmentioning

confidence: 99%

Influence of sodium chloride treatment and polysaccharides as debittering agent on the physicochemical properties, antioxidant capacity and sensory characteristics of bitter gourd (Momordica charantia) juice

et al. 2016

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The effects of sodium chloride (NaCl) (3.5%) solution and polysaccharides, such as carboxymethyl cellulose (CMC) (0.1, 0.3 and 0.5%) and gum arabic (5, 10 and 15%), on the physicochemical properties, antioxidant capacity and sensory characteristics of bitter gourd juice were investigated. An increase in the concentration of CMC and gum arabic significantly was observed to increase the lightness (L value) and the viscosity (mPas) of bitter gourd juice at all levels. Increased concentrations of gum arabic significantly increased the total soluble solids. The bitter gourd fruit treated with NaCl solution produced the highest lightness (L value) and scavenging activity of free radical 2,2-diphenyl-1-picrylhydrazyl of bitter gourd juice. Increased concentration of gum arabic up to 15% significantly increased the total phenolic content. The addition of 5% gum arabic effectively reduced the bitterness of the bitter gourd juice. Viscosity of the juice resulted in negative correlation for bitterness.

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Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency

Cited by 379 publications

References 63 publications

“Nature, green in leaf and stem”. Research on plants with medicinal properties in Suriname

“Nature, green in leaf and stem”. Research on plants with medicinal properties in Suriname

Therapeutic Potential of Plant Phenolics for the Management of Diabetic Retinopathy

Influence of sodium chloride treatment and polysaccharides as debittering agent on the physicochemical properties, antioxidant capacity and sensory characteristics of bitter gourd (Momordica charantia) juice

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