Antidiabetic Effects of Corni Fructus Extract on Blood Glucose and Insulin Resistance in db/db Mice

Kim, Hye Jeong; Kim, Kil-Soo; Lee, Tae-Jong; Kim, Young Chul

doi:10.5487/tr.2009.25.2.093

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…Reports have previously demonstrated the beneficial action of Corni fructus on diet-induced IR and glucose intolerance. 42 In this research, OGTT indicated that the AUC of glucose tolerance in CIG was lower appreciably than that in the DM ( p < 0.05) ( Fig. 4B and C ), showing that CIG has an effective improvement of glucose tolerance in diabetic mice.…”

Section: Discussionsupporting

confidence: 51%

Hypoglycemic, hypolipidemic and antioxidant effects of iridoid glycosides extracted from Corni fructus: possible involvement of the PI3K–Akt/PKB signaling pathway

et al. 2018

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Section: Discussionsupporting

confidence: 51%

Hypoglycemic, hypolipidemic and antioxidant effects of iridoid glycosides extracted from Corni fructus: possible involvement of the PI3K–Akt/PKB signaling pathway

et al. 2018

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“…Cornus officinalis Siebold & Zucc. [Cornaceae] extract can promote the expression of peroxisome proliferator-activated receptor γ (PPAR-γ) in adipocytes, increase the expression of recombinant glucose transporter 4 (GLUT4) and adiponectin, improve insulin resistance, and increase glucose utilization, ultimately achieving the effect of lowering the blood sugar levels ( Kim et al, 2009 ). Thus, SHTXF treatment in diabetic IR appears to be the result of multiple factors, multiple pathways, and multi-target regulatory networks.…”

Section: Discussionmentioning

confidence: 99%

Sanghuang Tongxie Formula Ameliorates Insulin Resistance in Drosophila Through Regulating PI3K/Akt Signaling

Cao

Zhang

et al. 2022

Front. Pharmacol.

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Insulin resistance (IR) is a pivotal pathological characteristic that affects the occurrence and development of type 2 diabetes mellitus (T2DM). Thus, the effective control of IR is of great significance for diabetes prevention and treatment. Traditional Chinese medicine (TCM) represents a valuable tool handed down to the world by the Chinese nation and has a long history of use for diabetes clinical therapy. In this study, we focused on a self-drafted TCM-patented formula, Sanghuang Tongxie Formula (SHTXF), which exhibits clinical efficacy in the treatment of diabetes. To explore the effect and molecular mechanism of SHTXF on IR in vivo, Drosophila melanogaster was used and a (Collagen) Cg > InRK1409A diabetic IR fly model was established. SHTXF water extract was found to contribute toward carbohydrate clearance from the circulating system by converting it into triglycerides (TAG), not glycogen, for nutrient storage. In addition, SHTXF activated phosphatidylinositol-3-kinase (PI3K) activity and improved protein kinase B (PKB, also termed Akt) phosphorylation. Finally, SHTXF promoted Drosophila Forkhead Box O (dFoxO) cytoplasmic localization and inhibited its transcriptional activity. Taken together, these findings not only highlight the positive role of SHTXF in ameliorating IR via the PI3K/Akt pathway but also provide potential drug targets and key insights for use in T2DM clinical treatment strategies.

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“…Saponins and phenolic acid are known to have antioxidant activities (Rong et al ., 1995) . Recently, it has been reported that Corni Fructus has beneficial effect on advanced glycation end product-mediated renal injury in STZ-treated diabetic rats (Yamabe et al ., 2007) and db/db mice (Kim et al ., 2009 , Kim and Kim, 2010) .…”

Section: Introductionmentioning

confidence: 99%

Antioxidative Action of Corni Fructus Aqueous Extract on Kidneys of Diabetic Mice

Kim¹,

Kim²,

Kim³

2011

Toxicological Research

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This study investigated the antioxidative action of Corni Fructus aqueous extract on kidneys of diabetic mice. The electron donating abilities of Corni Fructus aqueous extract and its antioxidant activities (XO, SOD, CAT, GST, eNOS) in kidneys of C57BL/6 or db/db mice were evaluated. For in vivo study, seven week-old male mice were divided into normal control group (NC, C57BL/6 mice) , diabetic control group (DC, db/db mice) and Corni Fructus (500 mg/kg/day for 8 weeks) treated diabetic group (DCF, db/db mice) . The electron donating abilities of Corni Fructus aqueous extract exhibited 7%, 24.4%, and 42.7% at concentrations of 100, 500, and 1000 μg/ml, respectively. The activity of XO in the DCF group was significantly lower than the DC group by 35% (p < 0.05) . The SOD activity was significantly higher in the DCF group than the DC group by 26% (p < 0.05) . The activities of CAT and GST were lowered in the DCF group than the DC group by 26% (p < 0.05) and 7.6%, respectively. The mRNA expression of eNOS in kidneys was lower in the DCF group than the DC group by 24%. These results indicate that Corni Fructus reduced oxidation stress as evidenced by the restoration of the enzymatic antioxidative defense system in renal tissues of db/db mice. It is suggested that these antioxidative actions of Corni Fructus on renal tissues in db/db mice could contribute to its renoprotective effects on diabetic nephropathy.

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Antidiabetic Effects of Corni Fructus Extract on Blood Glucose and Insulin Resistance in db/db Mice

Cited by 5 publications

References 20 publications

Hypoglycemic, hypolipidemic and antioxidant effects of iridoid glycosides extracted from Corni fructus: possible involvement of the PI3K–Akt/PKB signaling pathway

Hypoglycemic, hypolipidemic and antioxidant effects of iridoid glycosides extracted from Corni fructus: possible involvement of the PI3K–Akt/PKB signaling pathway

Sanghuang Tongxie Formula Ameliorates Insulin Resistance in Drosophila Through Regulating PI3K/Akt Signaling

Antioxidative Action of Corni Fructus Aqueous Extract on Kidneys of Diabetic Mice

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