Antidiabetic effects of artemisia species: A systematic review

Abstract

Background:Over the last century, human life style and food habits have drastically changed which lead to various chronic diseases. Diabetes mellitus is one such disease which is causing serious problems to human health. Allopathic drugs are not much effective in handling the disease and its complications. Hence focus has been turned towards the traditional system of medicine. Medicinal plants play an important role in the management of diabetes mellitus.Methods:Experimental studies conducted on species of Artemisia on diabetic animal models and human published since the year 2000 until April, 2017 were reviewed. Each article was critically appraised by two independent reviewers for their methodological quality using the JBIMAStARI tool.Result:A total of 14 studies were included in this review and the blood glucose data obtained from these critically reviewed studies clearly showed that both the aqueous and alcoholic extracts of species of Artemisia produced significant hypoglycemic effects in alloxan, Streptozotocin and high fat diet induced diabetic animals and diabetic humans with different mechanisms of action as compared to standard antidiabetic medications.Discussion and Conclusion:The antidiabetic effect of single or multiple doses of aqueous and alcoholic extracts of Artemisia species was due to the active compounds of these plants and they all are effective in lessening the blood glucose level in all of those experimental studies. Despite the presence of known antidiabetic medicines in the pharmaceutical market, therapeutic remedies from these medicinal plants have been utilized with success to treat this disorder and its complications with a relatively less side effects.

Bioactive Phenolics of the Genus Artemisia (Asteraceae): HPLC-DAD-ESI-TQ-MS/MS Profile of the Siberian Species and Their Inhibitory Potential Against α-Amylase and α-Glucosidase

“…Some studies have shown that plant species of the Artemisia genus, used in the ethnomedical systems of Asia, have antidiabetic properties (Dabe and Kefale, 2017 ). The people living in the territory of present-day Northern Asia or Siberia, widely used Artemisia extracts for the treatment of diabetes-like conditions.…”

“…(Tan et al, 1998 ; Bora and Sharma, 2011 ; Abad et al, 2012 ; Ivanescu et al, 2015 ; Pandey and Singh, 2017 ). It was observed that the various Artemisia aqueous and alcoholic extracts possessed an antidiabetic effect caused by hypoglycaemic action (Dabe and Kefale, 2017 ). Pharmacological data provides convincing evidence that the extracts of A. absinthium (Daradka and Abas, 2014 ), A. afra (Afolayan and Sunmonu, 2011 ), A. amygdalina (Ghazanfar et al, 2014 ), A. dracundulus (Ribnicky et al, 2006 ), A. judaica (Nofal et al, 2009 ), A. herba-alba (Awad et al, 2012 ), A. ludoviciana (Anaya-Eugenio et al, 2014 ), and A. sphaerocephala (Xing et al, 2009 ) were effective in streptozotocin- and alloxan-induced hyperglycemia experimental animal models due to their significant ability to reduce blood glucose level and protect against metabolic aberrations caused by diabetes.…”

Anti-Obesity Effects of Polyphenol Intake: Current Status and Future Possibilities

“…In Western and African folk medicine, several species of the genus Artemisia are used for their claimed healing properties and for the cure of specific ailments. The early in vitro antiobesity-effects [ 135 ] of Artemisia could be due to the presence of active compounds, such as terpenes, steroids, and saponins, and also the active ingredients, such as tannins and flavonoids [ 136 ]. Physalis alkekengi , also referred to as ground cherry, is an indigenous herb in Iran and many other regions of Asia such as China.…”

Research Advances on Health Effects of Edible Artemisia Species and Some Sesquiterpene Lactones Constituents

“…The result of this vast investigation showed the Artemisia species (extracts and essential oils) as exhibiting antiparasitic, anticancer and anti-inflammatory action in addition to antioxidant, wound healing, antinociceptive, immunoregulation, hepatoprotective, neuroprotective, anti-asthmatic, antidiabetic, antihypertensive, anti-adipogenic, anti-ulcerogenic, antiviral, antibacterial, antifungal, and anti-osteoporotic activities [ 10 , 11 , 12 , 13 , 18 , 19 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”