Antidiabetic effect of Phlomis anisodonta: Effects on hepatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes

Sarkhail, Parisa; Rahmanipour, Somayeh; Fadyevatan, S.; Mohammadirad, Azadeh; Dehghan, Gholamreza; Amin, Gholamreza; Shafiee, Abbas; Abdollahi, Mohammad

doi:10.1016/j.phrs.2007.07.003

Cited by 108 publications

(71 citation statements)

References 46 publications

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“…These results are similar to those found in studies with other antioxidants polyphenols that also prevented the rise in ADA activity (Szudelski, 2012;De Bona et al, 2014). In fact, the decrease of the ADA activity by Rutin treatment may contribute for the adenosine level control, which may act as an endogenous activator of the cellular antioxidant defense system (De Bona et al, 2013) and of inflammatory responses and protection of tissues from injuries (Sarkhail et al, 2007). An important aspect to be discussed in our study is that the prevention of increase of the total cholesterol by Rutin that can be associated with the hypolipidemic property exhibit by this polyphenol.…”

Section: Discussionsupporting

confidence: 88%

Rutin restores adenosine deaminase activity in serum and the liver and improves biochemical parameters in streptozotocin-induced diabetic rats

Chielle

Bonfanti

Bona

et al. 2016

Rev. bras. plantas med.

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denosine deaminase (ADA) is a critical control point in the regulation of adenosine levels. This study aimed to investigate the effects of a polyphenolic flavonoid, rutin, on the activity of ADA in serum, the cerebral cortex, liver, kidney, and biochemical parameters in diabetic rats. The animals were divided into four groups (n=6) for the following treatments: control; diabetic (streptozotocin 55 mg/kg); diabetic with rutin (100 mg/kg/day); diabetic with glibenclamide (10 mg/kg/day). After 30 days, ADA activity and biochemical parameters were analyzed. The ADA activity in the serum was significantly elevated in the diabetic group compared to the control group (p<0.01). The treatment with rutin prevented the increase in ADA activity in the STZinduced rats when compared to control group. Our data showed that rutin reduced glucose, LDL levels, and hepatic enzymes in comparison with the control group. These results demonstrate that the increase of ADA activity observed in diabetic rats may be an important indicator of the immunopathogenesis of hyperglycemic disorders and suggest that rutin is important for regulating the enzymatic activities associated with immune, hyperglycemic, and inflammatory response in diabetes mellitus.Keywords: rutin; adenosine deaminase activity; streptozotocin; Wistar rats; diabetes.RESUMO: Rutina restaura a atividade da Adenosina desaminase no soro e no fígado e melhora os parâmetros bioquímicos em ratos diabéticos induzidos por estreptozotocina. A Adenosina desaminase (ADA) representa um ponto de controle crítico na regulação dos níveis de adenosina. A rutina, um flavonóide polifenólico presente em muitas plantas, foi testado para verificar a sua influência na atividade da ADA no soro, córtex cerebral, fígado rim e parâmetros bioquímicos em ratos diabéticos. Os animais foram divididos em quatro grupos cada grupo com 6 animais), tal como: controle; diabética (estreptozotocina 55 mg/kg); diabética + rutina (100 mg/kg/dia); diabético + glibenclamida (10 mg/kg/dia). Após 30 dias foram analisadas a atividade da ADA sérica e tecidual e parâmetros bioquímicos. A atividade de ADA no soro foi significativamente elevada no grupo diabético quando comparado ao grupo controle (p<0,01). O tratamento com Rutina preveniu o aumento na atividade da ADA nos ratos diabéticos, quando comparado com o grupo controle. Os resultados mostraram que a rutina reduziu a glicose, os níveis de LDL e as enzimas hepáticas, em comparação com o grupo controle. Estes resultados mostram que o aumento da atividade da ADA observado em ratos diabéticos pode ser um indicador importante da imuno-patogênese de perturbações hiperglicêmicas e sugerem que a Rutina é importante na regulação das atividades enzimáticas associadas com a resposta imunitária, hiperglicêmica e inflamatória no Diabetes mellitus.

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Section: Discussionsupporting

confidence: 88%

Rutin restores adenosine deaminase activity in serum and the liver and improves biochemical parameters in streptozotocin-induced diabetic rats

Chielle

Bonfanti

Bona

et al. 2016

Rev. bras. plantas med.

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“…The results previously reported indicated that the phlomis leaf extract containing glycosides such as flavonoids, iridoids, diterpenoids, phenylpropanoids, triterpenoids and other phenolic compounds possibility contributed to the process of nanoparticle synthesis [15]. Furthermore, based on the above results, it was clear that the functional groups like -OH (hydroxyl), -C=O (Carbonil) and C-N (amine) present in the leaf extract were involved in synthesis of AgNPs.…”

Section: Uv-vis Spectral Studies and Ft-ir Analysismentioning

confidence: 72%

“…About 17 species of this plant are in Iran, of which 10 are endemic. A review of several studies shows that phlomis species have unique aromatic compounds, medicinal properties and antimicrobial activity [14,15].…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of silver nanoparticles using phlomis leaf extract and investigation of their antibacterial activity

et al. 2016

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In recent years, the green synthesis of silver nanoparticles using various plant extracts has attracted great attention. This is because, these methods are simple, inexpensive and, eco-friendly. In this study, it was observed that silver ions were reduced by phlomis leaf extract after 5 min, leading to the formation of crystalline silver nanoparticles. Phlomis species is known as a rich source of flavonoids, phenylpropanoids and other phenolic compounds. The silver nanoparticles produced by the phlomis extract were characterized by different techniques including UV-vis spectrophotometry, X-ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and FT-IR. The SEM and TEM results indicated that AgNPs were predominantly spherical in shape with an average particle size of 25 nm. In addition, the antibacterial activity of biologically synthesized nanopartilcles against Gram-positive (Staphyloccocus aureus and Bacillus cereus) and Gram-negative (Salmonella typhimurium and Escherichia coli) bacteria was proved. This study, therefore, showed that the phlomis leaf extract could be used for the green synthesis of silver nanoparticles with the appropriate antibacterial activity.

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“…Studies have shown that glibenclamide is able to reduce levels of TNF-α and IL-1β alongside oxidative stress biomarkers [58][59][60][61]. On the other hand, Cocks et al (1990) [62] discovered a new property for glibenclamide which is a competitive antagonism of TXA2 receptors in coronary artery.…”

Section: Discussionmentioning

confidence: 99%

Benefit of nicorandil using an immunologic murine model of experimental colitis

et al. 2009

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Inflammatoryboweldisease(IBD)isachronicinflammatoryconditionwithanunknownetiology.Nicorandil,apotassiumchannel opener, has been used for many years for the treatment of angina. Recently, it has been shown that nicorandil possesses some novel traits such as anti-apoptotic, gastroprotective, free radical scavenging, and anti-inflammatory properties. Therefore, we set out to examine the possible beneficial effect of nicorandil in a rat model of IBD. Colitis was induced by rectal administration of 2,4,6-trintrobenzene sulphonic acid (TNBS) into rats. Groups of animals used in this study were sham, control, and exposure to dexamethasone,nicorandil,glibenclamid(apureadenosinetriphosphatesensitivepotassiumchannel(KATP)blocker),ornicorandilplus glibenclamid.Drugswereadministeredbygavageandanimalsweresacrificedafter7days.Biochemicalmarkers,includingTNF-αand IL-1β,ferricreducing/antioxidantpower(FRAP),myeloperoxidase(MPO)activityandthiobarbitoricacid-reactivesubstance(TBARS), weremeasuredinthehomogenateofcolonictissue.Resultsindicatethatnicorandilsignificantlyreducesmacroscopicandhistological damageinducedbyTNBS.NicorandildiminishesMPOactivityandlevelsofTBARS,TNF-α,andIL-1βindamagedcolonictissuewith aconcomitantincreaseinFRAPvalue(P<0.01).Theseeffectswerenotreversedbycoadministrationofglibenclamide.Inconclusion, nicorandilisabletoameliorateexperimentalIBDwithadoseinwhichitdoesnotshowanyanti-hypertensiveeffect,andthemechanism ofwhichispartiallyortotallyindependentfromKATPchannels.Itishypothesizedthatnitricoxidedonationandfree-radicalscavenging propertiesofnicorandilupregulateendothelialnitricoxidesynthasemayberesponsibleforthisphenomenon.Thesefindingssuggest thatnicorandilcanbeusefulintreatmentofIBD,althoughfurtherinvestigationsareneededtoelucidatethemechanismsinvolved.

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Antidiabetic effect of Phlomis anisodonta: Effects on hepatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes

Cited by 108 publications

References 46 publications

Rutin restores adenosine deaminase activity in serum and the liver and improves biochemical parameters in streptozotocin-induced diabetic rats

Rutin restores adenosine deaminase activity in serum and the liver and improves biochemical parameters in streptozotocin-induced diabetic rats

Green synthesis of silver nanoparticles using phlomis leaf extract and investigation of their antibacterial activity

Benefit of nicorandil using an immunologic murine model of experimental colitis

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