Antidiabetic Effect of Nono (A Nigerian Fermented Milk) on Alloxan-Induced Diabetic Rats

., S.A. Laleye; Igbakin, A. P.; Akinyanju, J. A.

doi:10.3923/ajft.2008.394.398

Cited by 7 publications

(7 citation statements)

References 13 publications

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“…15 In 2007, Lali et al proved that a Nano product containing lactobacillus causes a decrease in blood sugar of mice with diabetes through aloxone. 11 In 2009, Harissa et al showed that Lactobacillus acidophilus causes a decrease in free radicals and reactive oxygen species (ROS). These reactive compounds cause a disorder in the nitric oxide strain of diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

“…It is likely that when the amount of lactobacillus increases in the intestine, the demand for glucose goes up and as a result leads to a decrease in released glucose in serum. 11,14 Further, because probiotics have an antioxidant trait, they prevent destruction of β-Langerhans cells *Significance of data comparing diabetic group treated with carrot juice vs. diabetic group treated with mixture of Lactobacillus casei and carrot juice (p = 0.005). **Significance of data comparing diabetic group treated with mixture of Lactobacillus casei and carrot juice vs. diabetic group treated with carrot juice and control group treated with carrot juice (p = 0.005 and 0.01).…”

Section: Discussionmentioning

confidence: 99%

“…Researchers attribute the decrease in blood sugar to an increase in the number of lactobacilli in the intestine which consume glucose and thereby limit glucose absorption and distribution to other organs in the host. 11,14,21 Nevertheless, more studies are required to define the exact mechanism of this process and it is likely that other lactobacilli possess this characteristic. Through more research, it may be possible to discover a simpler way to prevent and treat diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, probiotics that contain live microorganisms can have healing effects provided that the host uses a sufficient dose. 11 Bacteria producing lactic acid, especially lactobacillus, are commonly considered to be part of the digestive system ecosystem. Proven potential effects of probiotic microorganisms include aiding digestion of lactose in the intestine, alleviating diarrhoea and constipation, decreasing cholesterol level, controlling colon cancer, reinforcing of the immune system, stimulating intestinal microflora growth, preventing increases in allergic reactions, and restraining pathogen growth in the intestine.…”

Section: Introductionmentioning

confidence: 99%

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Investigating the effects of Lactobacillus casei on some biochemical parameters in diabetic mice

Asgharzadeh

Tanomand

Ashoori

et al. 2017

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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Aims: Diabetes mellitus is a metabolic disorder characterised by inadequate pancreatic insulin secretion or the insulin present being unable to perform its function properly. Consistent with the beneficial effects of probiotics and their ability to lower glucose levels, an impact on diabetes treatment is also expected. The aim of this study was to evaluate the effect of Lactobacillus casei on various either biochemical parameters in a diabetic mice model. Methods: In the present study, 24 mice were divided into diabetic and control groups. Further, each group was categorised into two subgroups. The diabetic and control subgroups were fed carrot juice or Lactobacillus casei in carrot juice. Diabetes was induced by streptozotocin (STZ). For 30 days, the mice were fed 2 ml carrot juice, and Lactobacillus casei in carrot juice (with lactobacillus 10 9 cfu/ml) by gavage. Then, blood samples were collected to assay biochemical parameters. Results: The results of this study showed that Lactobacillus casei (ATCC39392) significantly reduced blood glucose (BG) levels in diabetic mice receiving the probiotic, but did not cause a significant change in BG levels in control mice receiving the probiotic. When comparing insulin, insulin-like growth factor I (IGF-I) and C-peptide in the four groups, it was found that insulin and C-peptide were significantly different in all groups except for the control group treated with a mixture of probiotic Lactobacillus casei and carrot juice. Conclusion: Our results showed that probiotic Lactobacillus casei effectively reduces BG levels in diabetic mice treated with this bacterium.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Investigating the effects of Lactobacillus casei on some biochemical parameters in diabetic mice

Asgharzadeh

Tanomand

Ashoori

et al. 2017

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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“…One other study was excluded as it reported the same outcomes published previously in line with other new but irrelevant results [38]. Six other studies were excluded as they evaluated the effects of synbiotics [39][40][41][42][43] or prebiotics [44]. Three animal reports that were published in languages other than English were excluded as well [45][46][47].…”

Section: Probiotics and Diabetesmentioning

confidence: 99%

Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review

Razmpoosh

Javadi

Ejtahed

et al. 2015

Diabetes Metabolism Res

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Probiotics have been suggested to play an important role in the management of diabetes. We conducted a systematic review on the role of probiotics in modulating parameters related to diabetes in animal and human experiments. We searched Pubmed, Scopus and Cochrane central until June 2014, concerning the effects of probiotics on hyperglycemia, hyperinsulinemia and their anti-diabetic efficacies by modulating the activities of proinflammatory and antioxidant factors. Our initial search retrieved 1120 reports. After screening titles and abstracts, 72 full-text articles were reviewed for eligibility. Ultimately, 33 articles met our inclusion criteria consisting of five human and twenty eight animal reports. Lactobacillus strains were, in particular, used in all studies with or without other strains. We found that probiotics have beneficial effects on glycemic controls, as all human studies showed significant reductions in at least one of the primary outcome endpoints which were the levels of fasting plasma glucose, postprandial blood glucose, glycated haemoglobin, insulin, insulin resistance and onset of diabetes; similarly, all the animal reports, except for two, documented significant changes in these parameters. Regarding secondary outcome measures, that is, lipid profiles, pro-inflammatory and anti-oxidant factors, only one human and one animal study failed to show any significant changes in any of these parameters. This systematic review generally demonstrated beneficial effects of the probiotic administration, especially Lactobacillus sub-strains, on the management of diabetes-related blood parameters, although, more evidence, especially from human trials, is needed to confirm these effects and also to conduct a meta-analysis. Copyright © 2015 John Wiley & Sons, Ltd.

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Protective and therapeutic effects of two novel strains of Lactobacilli on diabetes-associated disorders induced by a high level of fructose

Alsuhaymi

Darwish²,

Khattab³

2021

Mol Biol Rep

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Antidiabetic Effect of Nono (A Nigerian Fermented Milk) on Alloxan-Induced Diabetic Rats

Cited by 7 publications

References 13 publications

Investigating the effects of Lactobacillus casei on some biochemical parameters in diabetic mice

Investigating the effects of Lactobacillus casei on some biochemical parameters in diabetic mice

Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review

Protective and therapeutic effects of two novel strains of Lactobacilli on diabetes-associated disorders induced by a high level of fructose

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