Antidiabetic effect of camel milk on alloxan-induced diabetic dogs

Sboui, Amel; Khorchani, Touhami; Agrebi, A.; Djegham, M.; Mokni, M; Belhadj, O.; Hached, Farhat

doi:10.5897/ajmr12.035

Cited by 7 publications

(5 citation statements)

References 15 publications

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“…These fi ndings were supported by the signifi cant inverse correlation between the blood glucose levels (RBG and FBG) and body weight in the studied animals. The hypoglycemic and the hypolipidemic eff ects of CMK treatment in the diabetic animals (Group D-CMK), were in accordance with similar reports in diabetic patients [ 4 , 5 ] and experimental animals [ 6 ] and agreed with the hypoglycemic and the anabolic eff ects of CMK when used as an adjuvant to insulin therapy in T1DM patients [ 30 ] . Those patients had 30-35 % reduction in the daily insulin requirements, decreased microalbuminuria, higher body mass index and better scores of the quality of life [ 30 ] .…”

Section: Correlation Analysissupporting

confidence: 89%

The Antidiabetic Action of Camel Milk in Experimental Type 2 Diabetes Mellitus: An Overview on the Changes in Incretin Hormones, Insulin Resistance, and Inflammatory Cytokines

Aa¹

2014

Horm Metab Res

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Folk medicine stories accredited the aptitude of camel milk (CMK) as a hypoglycemic agent and recent studies have confirmed this in the diabetic patients and experimental animals. However, the mechanism(s) by which CMK influences glucose homeostasis is yet unclear. The current study investigated the changes in the glucose homeostatic parameters, the incretin hormones, and the inflammatory cytokines in the CMK-treated diabetic animals. A model of type 2 diabetes mellitus was induced in rats by intraperitoneal injection of streptozotocin 40 mg/kg/day for 4 repeated doses. Camel milk treatment was administered for 8 weeks. The changes in glucagon like peptide-1 (GLP-1), glucose dependent insulinotropic peptide (GIP), glucose tolerance, fasting and glucose-stimulated insulin secretion, insulin resistance (IR), TNF-α, TGF-β1, lipid profile, atherogenic index (AI), and body weight were investigated. The untreated diabetic animals showed hyperglycemia, increased HOMA-IR, hyperlipidemia, elevated AI, high serum incretins [GLP-1 and GIP], TNF-α, and TGF-β1 levels and weight loss as compared with the control group. Camel milk treatment to the diabetic animals resulted in significant lowered fasting glucose level, hypolipidemia, decreased HOMA-IR, recovery of insulin secretion, weight gain, and no mortality during the study. Additionally, CMK inhibits the diabetes-induced elevation in incretin hormones, TNF-α and TGF-β1 levels. The increase in glucose-stimulated insulin secretion, decreased HOMA-IR, modulation of the secretion and/or the action of incretins, and the anti-inflammatory effect are anticipated mechanisms to the antidiabetic effect of CMK and suggest it as a valuable adjuvant antidiabetic therapy.

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Section: Correlation Analysissupporting

confidence: 89%

The Antidiabetic Action of Camel Milk in Experimental Type 2 Diabetes Mellitus: An Overview on the Changes in Incretin Hormones, Insulin Resistance, and Inflammatory Cytokines

Aa¹

2014

Horm Metab Res

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“…Camel milk is the most common product in arid regions. The beneficial effects of camel milk, which include the prevention of diseases and conditions such as gastroenteritis, tuberculosis, diabetes and hypertension, have been demonstrated experimentally (Quan et al, 2008 ;Sboui et al, 2010). Therefore, improving the therapeutic value of camel milk has received great attention.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of camel milk casein before and after in vitro simulated enzymatic digestion

et al. 2014

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The effect of a successive in vitro hydrolysis by pepsin and pancreatin on the free radical scavenging activity of camel milk casein was investigated in order to assess the effect of gastro-intestinal digestion. Hydrolysis of camel casein was controlled by reversed-phase high performance liquid chromatography. Anti-oxidant activity was measured by the 2,2'-azino-bis-(3-ethylbensothiazoline-6sulfonic acid) (ABTS) method. The Trolox equivalent antioxidant capacity (TEAC) values of camel casein and its hydrolysate were 1.6±0.12 µmol TE/mg protein and 0.25 µmol TE/µmol eq. NH 2 , respectively. After digestion, the scavenging activity of the casein peptides was more efficient than those reported in the literature regarding digestive hydrolysates of camel milk, colostrum and whey proteins.

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“…In this regard, functional foods and nutraceuticals have emerged as adjuvant or alternative to chemotherapy especially in the prevention and management of human diseases and for maintaining optimum health state [20]. Interest in camel milk usage for human nutrition is increasing due to its distinct composition and unique biofunctional properties [21].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Effects of Camel Milk against Some Bacterial Pathogens

Yassin¹,

Soliman²,

Mostafa³

et al. 2015

JFNR

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The present study was aimed to investigate the protective effects of camel milk against pathogenicity induced by Staphylococcus aureus (S. aureus) and E. coli in Wistar rats. Sixty healthy adult male Wistar rats were divided into six groups (10 per group). Group 1 served as a control without any treatment. Group 2 received camel milk for two consecutive weeks. Group 3 injected intraperitoneally (IP) by S. aureus in a doses of 2x10 9 CFU/ml per rat. Group 4 injected IP by E.coli in a dose of 5x10 10 CFU/ml per rat. Group 5 supplemented with camel milk for two consecutive weeks and then injected IP by S.aureus (2x10 9 CFU/ml per rat). Group 6 supplemented with camel milk for two consecutive weeks and then injected IP by E.coli (5x10 10 CFU/ml per rat). All animals were decapitated after 3 weeks, serum was extracted and liver, kidney and lung tissues were taken for pathogen isolation. The isolation rate and pathogenicity of S. aureus and E. coli was high in rats injected pathogens alone (group 3 and 4) compared to camel milk and pathogens administered rats (group 5 and 6). The isolation of S. aureus and E. coli was high in intestine, then lung, kidney and liver. Prior camel milk supplementation ameliorated the degree of pathogenicity induced by pathogens. Camel milk had synergistic action with ciprofloxacin against S. aureus and E. coli to reduce bacterial resistance and decrease the dose of antibiotics. Pathogens injection alone induced significant amelioration in liver and kidney functions and prior camel milk administration inhibited such changes. Moreover, oxidative stress represented by the increase in malondialdehyde levels in serum of pathogens injected rats was decreased by prior camel milk administration. In conclusion, camel milk has beneficial role as antibacterial food supplement against S.aureus and E.coli pathogenicity in Wistar rats.

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Antidiabetic effect of camel milk on alloxan-induced diabetic dogs

Cited by 7 publications

References 15 publications

The Antidiabetic Action of Camel Milk in Experimental Type 2 Diabetes Mellitus: An Overview on the Changes in Incretin Hormones, Insulin Resistance, and Inflammatory Cytokines

The Antidiabetic Action of Camel Milk in Experimental Type 2 Diabetes Mellitus: An Overview on the Changes in Incretin Hormones, Insulin Resistance, and Inflammatory Cytokines

Antioxidant activity of camel milk casein before and after in vitro simulated enzymatic digestion

Antimicrobial Effects of Camel Milk against Some Bacterial Pathogens

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