Antidiabetic effect of an extract of nutricultured Brassica napus containing vanadium from a Jeju water concentrate

Yun, Ji-Hyun; Park, Sung-Hwan; Choi, Goo-Hee; Park, In-Jae; Lee, Jin Ha; Lee, Ok‐Hwan; Kim, Jung-Hyon; Seo, Yun-Hee; Cho, Ju-Hyun

doi:10.1007/s10068-018-0436-8

Cited by 4 publications

(2 citation statements)

References 34 publications

(31 reference statements)

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“…In addition, Akbari and colleagues have recently described the hypoglycemic properties of Brassica napus L. on diabetic rats (Akbari et al, 2016). Finally, the consumption of Brassicaceae vegetables has been associated with significant decrease of serum insulin concentration in type II diabetes patients (Bahadoran et al, 2012; Yokozawa, Kim, Cho, Yamabi, & Choi, 2003; Yun et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Eruca sativa Mill. seed extract promotes anti‐obesity and hypoglycemic effects in mice fed with a high‐fat diet

Piragine

Flori

Mannelli

et al. 2020

Phytotherapy Research

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Obesity is currently considered a major source of morbidity, with dramatic complications on health status and life expectancy. Several studies demonstrated the positive effects of Brassicaceae vegetables on obesity and related diseases, partially attributing these beneficial properties to glucosinolates and their derivatives isothiocyanates. Recently, isothiocyanates have been described as a hydrogen sulfide (H 2 S)-releasing moiety, suggesting that H 2 S may be at least in part responsible for the beneficial effects of Brassicaceae. In this work, the metabolic effects of an extract obtained from Eruca sativa Mill. seeds (E.S., Brassicaceae), containing high levels of glucoerucin, were evaluated in an experimental model of obesity. Male balb/c mice were fed for 10 weeks with standard (Std) diet or high fat (HF) diet supplemented with E.S. E.S. significantly contained the body weight gain in this obesity model, improving also glucose homeostasis. Interestingly, lower values of white adipose tissue mass and a significant reduction of adipocytes size were also observed. Moreover, E.S. enhanced the adipocytes metabolism, improving the citrate synthase activity and reduced triglyceride levels in mice fed with HF diet. Taken together, these results suggest that E.S. is endowed with an interesting translational and nutraceutical value in the prevention of metabolic disorders, suggesting that H 2 S could be a key player.

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Section: Discussionmentioning

confidence: 99%

Eruca sativa Mill. seed extract promotes anti‐obesity and hypoglycemic effects in mice fed with a high‐fat diet

Piragine

Flori

Mannelli

et al. 2020

Phytotherapy Research

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show abstract

“…The vanadium-containing extract was reported to exhibit anti-diabetic effects as well as reduced triglyceride accumulation and adipogenesis in in vivo models. The suggested mechanism of action involved AMPK-mediated upregulation of glycogen synthesis by enhanced triacylglycerol lipase activity resulting in increased glucose uptake in adipocytes [166].…”

Section: Vanadium-mediated Ampk Activation-reduced Adipogenesismentioning

confidence: 99%

Targeting Breast Cancer and Their Stem Cell Population through AMPK Activation: Novel Insights

Uprety

Abrahamse

2022

Cells

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Despite some significant advancements, breast cancer has become the most prevalent cancer in the world. One of the main reasons for failure in treatment and metastasis has been attributed to the presence of cancer initiating cells—cancer stem cells. Consequently, research is now being focussed on targeting cancer cells along with their stem cell population. Non-oncology drugs are gaining increasing attention for their potent anticancer activities. Metformin, a drug commonly used to treat type 2 diabetes, is the best example in this regard. It exerts its therapeutic action by activating 5′ adenosine monophosphate-activated protein kinase (AMPK). Activated AMPK subsequently phosphorylates and targets several cellular pathways involved in cell growth and proliferation and the maintenance of stem-like properties of cancer stem cells. Therefore, AMPK is emerging as a target of choice for developing effective anticancer drugs. Vanadium compounds are well-known PTP inhibitors and AMPK activators. They find extensive applications in treatment of diabetes and obesity via PTP1B inhibition and AMPK-mediated inhibition of adipogenesis. However, their role in targeting cancer stem cells has not been explored yet. This review is an attempt to establish the applications of insulin mimetic vanadium compounds for the treatment of breast cancer by AMPK activation and PTP1B inhibition pathways.

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Poly (hydroquinone-oxovanadium (IV)) porous hollow microspheres for voltammetric detection of phenol

Shahbakhsh

Saravani

Narouie

et al. 2021

Microchemical Journal

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Antidiabetic effect of an extract of nutricultured Brassica napus containing vanadium from a Jeju water concentrate

Cited by 4 publications

References 34 publications

Eruca sativa Mill. seed extract promotes anti‐obesity and hypoglycemic effects in mice fed with a high‐fat diet

Eruca sativa Mill. seed extract promotes anti‐obesity and hypoglycemic effects in mice fed with a high‐fat diet

Targeting Breast Cancer and Their Stem Cell Population through AMPK Activation: Novel Insights

Poly (hydroquinone-oxovanadium (IV)) porous hollow microspheres for voltammetric detection of phenol

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