Antidiabetic Compounds in<i> Syzygium cumini</i> Decoction and Ready to Serve Herbal Drink

Perera, Rasika; Ekanayake, S.; Ranaweera, K. K. D. S.

doi:10.1155/2017/1083589

Cited by 16 publications

(8 citation statements)

References 20 publications

(19 reference statements)

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“…Further, gallic acid and umbelliferone were determined as the active compounds in the decoction by TLC and were confirmed by co-chromatography with authentic compounds. The present investigation confirmed the presence of gallic acid, ellagic acid, and umbelliferone which are proven to have antidiabetic activities in the decoction and the RTS herbal drink prepared with the decoction 43 .…”

Section: Storage and Marketingsupporting

confidence: 80%

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2018

IJPSR

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Syzygium cumini (L.) is a widely used medicinal plant for the management of various diseases. Syzygium cumini posses various chemical constituent which are responsible for pharmacological activity. This plant reported to possess many pharmacological activities like antidiabetic activity, anti-oxidant, anti-inflammatory, anti-diarrhoeal activity, antiviral, antifertility activity, gastroprotective, antipyretic, antihistaminic, antimicrobial and antiplaque. The present review presents specific information on morphology of plant, cultivation of plant, traditional uses and pharmacological actions of S. cumini (L.). Further applications of Syzygium cumini (Linn.) in the field of novel drug delivery has been also elaborated in the review. Apart from its application in the management of various ailments there is need to explore chemical and toxicity concern of Syzygium cumini (Linn.). INTRODUCTION: There has been an increasing demand for health promoting food products by the consumers all over the world. This has led to the new hybrid term between nutrients and pharmaceuticals, 'nutraceuticals' coined by Dr. Stephen L. DeFelice, in the year 1989 1. Nutraceuticals are diet supplements that deliver a concentrated form of a bioactive component from a food and used with the purpose of enhancing health in dosages that sometimes exceeds that of the normal foods 2. Medicinal plants have been the part and parcel of human society to combat diseases since the dawn of human society to combat diseases since the dawn of human civilization 3 .

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Section: Storage and Marketingsupporting

confidence: 80%

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2018

IJPSR

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“…e obese individual has increased adipose tissue producing a number of substances that decrease the body's ability to convert glucose into energy. Type 2 diabetes already affects children and adolescents [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Identification of Bioactive Compounds and Analysis of Inhibitory Potential of the Digestive Enzymes fromSyzygiumsp. Extracts

Freitas

Oliveira

Mendonça

et al. 2019

Journal of Chemistry

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Diabetes and obesity represent major public health problems worldwide. High cost of medicines and drug treatments propose the research for less expensive alternatives, such as enzymatic inhibitors present in medicinal plants from natural sources. An example of such medicinal plant is the jambolan Syzygium sp., which is referred to be hypoglycemic and efficient in weight loss. With this in mind, we identified the bioactive compounds from Syzygium sp. commercial teas and evaluated the inhibitory potential and the antioxidant activity of digestive enzymes from a simulated gastric fluid. Syzygium sp. samples showed low percentages of enzymatic inhibition at 1 : 200 dilution. Antioxidant activity was significant, although it was not expressive of the contents of total phenolic compounds, tannins, flavonoids, flavones, and alkaloids. Maldi-Tof spectroscopy suggested the presence of luteolin in Syzygium sp. samples. Molecular docking predicted that luteolin binds at the α-amylase catalytic site in a similar manner as acarbose, the carbohydrate inhibitor from the enzyme crystallographic structure. The phytochemical content and biological activity were distinct among samples from commercial teas. Thus, additional studies should be conducted to elucidate efficacy and safety of Syzygium sp. extracts, especially in vivo experiments. Syzygium sp. might be in the near future recommended as a medicinal plant in low cost diabetes and obesity treatments.

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“…Moreover, the same study revealed that the water extract exerts the highest α -glucosidase inhibitory activity with an IC 50 value of 0.69 µ g/mL. Several antidiabetic compounds as gallic acid, umbelliferone, and ellagic acid were identified in the aqueous extract of S. cumini bark [ 56 ]. The antioxidant activity of the water extract of S. cumini was determined using 2, 2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), ferric reducing antioxidant power (FRAP), and nitric oxide (NO) assays [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

Antidiabetic Activity of Widely Used Medicinal Plants in the Sri Lankan Traditional Healthcare System: New Insight to Medicinal Flora in Sri Lanka

Wasana

Attanayake

Jayatilaka

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The use of medicinal plant extracts and their isolated bioactive compounds for the management of diabetes mellitus has been tremendously increased in recent decades. The present study aimed at providing in-depth information on medicinal flora that has been widely used in the Sri Lankan traditional healthcare system for the management of diabetes mellitus. The data of this review article were obtained from published articles from January 2000 to September 2020 in scientific databases of PubMed, Web of Science, and Google Scholar. In this review, a total number of 18 medicinal plants with the antidiabetic activity were expressed, and their isolated antidiabetic active compounds were highlighted as new drug leads. Results of the reported studies revealed that medicinal plants exert a potent antidiabetic activity via both in vitro and in vivo study settings. However, bioactive compounds and antidiabetic mechanism (s) of action of many of the reported medicinal plants have not been isolated/elucidated the structure in detail, to date. Reported antidiabetic medicinal plants with other properties such as antioxidant and antihyperlipidemic activities deliver new entities for the development of antidiabetic agents with multiple therapeutic targets. This is a comprehensive review on potential antidiabetic activities of the Sri Lankan medicinal plants that have been widely used in the traditional healthcare system. The information presented here would fill the gap between the use of them by traditional healers in the traditional medicine healthcare system in Sri Lanka and their potency for development of new drug entities in future.

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Antidiabetic Compounds in Syzygium cumini Decoction and Ready to Serve Herbal Drink

Cited by 16 publications

References 20 publications

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Identification of Bioactive Compounds and Analysis of Inhibitory Potential of the Digestive Enzymes fromSyzygiumsp. Extracts

Antidiabetic Activity of Widely Used Medicinal Plants in the Sri Lankan Traditional Healthcare System: New Insight to Medicinal Flora in Sri Lanka

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