Antidiabetic Attributes of Desert and Steppic Plants: A Review

Harlev, Eli; Nevo, Eviatar; Mirsky, Nitsa; Ofir, Rivka

doi:10.1055/s-0032-1328331

Cited by 40 publications

(29 citation statements)

References 67 publications

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“…This result is in agreement with previous investigations where animals suffering from insulin dependent diabetics (type 1) showed increased lipid peroxidation [21,33]. It was also reported that diabetic patients are more susceptible to membrane damage [32,34]. However, mixture of PUFAs from stem bark Alstonia boonei and antidiabetic drug (METAG) caused a significant reduction in MDA content of diabetic-induced rats.…”

Section: Discussionsupporting

confidence: 92%

PUFAs from Stem Bark of Alstonia boonei Synergistically Modulates Diabetic, Hepatic and Androgenic Damage by Low Expression of COX-2 and iNOS in Rats

Ajiboye¹,

Akintunde²,

So³

et al. 2017

J Mol Biomark Diagn

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PUFAs, from the stem bark extract of Alstonia boonei (SBEAB) was hypothesized to possess anti-inflammatory, antioxidant, anti-diabetic, pro-spermatogenic and hepatoprotective activities. The present study investigated the possible biochemical and molecular mechanisms underlying the hepatoprotective and testoprotective effects of SBEAB in diabetic rat. Biomarkers of hepatic and testicular damage, histological and immunohistochemical techniques were used. The expression of cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) were also estimated. SBEAB administered orally at dose of 100 mg/kg for 14 days significantly lowered the activities of serum transaminases and MDA levels induced by single intraperitoneal administration of streptozotoxin (STREP) (80 mg/kg) and preserved the integrity of both hepatocytes and spermatocytes. Also, SBEAB elevated the STREPinduced reduced activities of Δ5-17β-HSD and Δ5-17β-HSD with corresponding decrease in the activity of CAT. SBEAB inhibited the STREP induced expression of COX-2 and iNOS. The protective effect of SBEAB was compared to that of metaglomide (METAG), an established anti-diabetic drug. METAG treatment on hepatic damage was most efficacious in diabetic rats; followed by post and pre-treatment respectively while pre-and post-treatment were more efficacious on testicular damage than anti-diabetic drug. Furthermore, pre and post-treatment were more efficacious in preventing pro-inflammation and testicular cancer in diabetic rats than METAG-administration. We therefore concluded that the repression of genes encoding COX-2 and iNOS proteins by SBEAB validates the molecular basis of testicular protection and further suggests the links between the hepatocellular damage and male reproductive dysfunctions in diabetic individuals.

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Section: Discussionsupporting

confidence: 92%

PUFAs from Stem Bark of Alstonia boonei Synergistically Modulates Diabetic, Hepatic and Androgenic Damage by Low Expression of COX-2 and iNOS in Rats

Ajiboye¹,

Akintunde²,

So³

et al. 2017

J Mol Biomark Diagn

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“…These irreversible oxidative modifications modulate redox-sensitive signaling pathways and lead to altered inflammation, endothelial dysfunction, impaired secretion of insulin, and impaired use of glucose in the peripheral tissues [6]. Many plant extracts are known to restore these parameters in streptozotocin (STZ)-induced diabetes rats, and have been found to delay diabetic complications as a result of their antioxidant potential [7]. However, currently available drugs for diabetes mellitus show many limitations, such as adverse effects, limited efficacy, and high rates of secondary failure [2].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes

Wang

et al. 2017

PLoS ONE

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This study evaluated the effects of Inonotus obliquus polysaccharides (IOs) on diabetes and other underlying mechanisms related to inflammatory factors and oxidative stress in a mouse model of streptozotocin (STZ)-induced diabetes. Four weeks administration of metformin (120 mg/kg) and IO1-4 (50%-80% alcohol precipitation), or IO5 (total 80% alcohol precipitation) at doses of 50 mg/kg reverses the abnormal changes of bodyweights and fasting blood glucose levels of diabetic mice. IOs significantly increased the insulin and pyruvate kinase levels in serum, and improved the synthesis of glycogen, especially for IO5. IOs restored the disturbed serum levels of superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde. The down-regulation of interleukin-2 receptor, matrix metalloproteinase-9, and the enhancement of interleukin-2 in serum of diabetic mice were significantly attenuated by IOs. Histologic and morphology examinations showed that IOs repaired the damage on kidney tissues, inhibited inflammatory infiltrate and extracellular matrix deposit injuries in diabetic mice. Compared with untreated diabetic mice, IOs decreased the expression of phosphor-NF-κB in the kidneys. These results show that IOs treatment attenuated diabetic and renal injure in STZ-induced diabetic mice, possibly through the modulation of oxidative stress and inflammatory factors. These results provide valuable evidences to support the use of I. obliquus as a hypoglycemic functional food and/or medicine.

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“…Whereas the Indian subcontinent is a renowned to be one of the major biodiversity center with about 45,000 plant varieties. In India, about 15,000 medicinal floras have been noted, and up to 7,000-7,500 plants are used by communities for therapeutics of various kinds of ailments [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…In similar kind of view, western Rajasthan (Part of the Thar desert) having peculiar kind of medicinal plants which are used by local people from long back based on conventional wisdom for therapeutics of diabetes and other diseases [5,12,13]. The local desert plants having a huge and unique number of secondary metabolites and phytocompounds through the specific stress conditions of desert.…”

Section: Introductionmentioning

confidence: 99%

Glucose Homeostatic and Pancreas Protective Potential of Tecomella Undulata Root Extract in Streptozotocin Induced Diabetic Rats .

Lal

Ram

2017

Asian J Pharm Clin Res

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Objective:The study was aimed to evaluate glucose homeostatic and pancreas protective potential of Tecomella undulata root extract in streptozotocin induced diabetic rats. Methods:The ethanolic root extract was prepared by following standard soxhlation methods. The experimental design was divided in to control and treated groups for 28 days of comparative experimental schedule. The body and organ weights, serum biochemistry, histo-pathology, hematology and toxicity profiles were assayed by following standard methods and protocols. Results:The treatment of ethanolic extract of root of T. undulata was significantly (p ≤ 0.001) reduced glucose levels at 7day, 14day, 21day and 28 days in comparison to standard drug of metformin. Correspondingly, lipid profile i.e. total cholesterol, HDL, VLDL, LDL and triglyceride were also altered significantly. Whereas, body and organs weight and hematological parameters were not shown significant changes. Subsequently, toxicity profile i.e. hepatic and renal parameters were remained under normal ranges. Corresponding, the treatment of ethanolic root extract caused normalcy of histoarchitecture of pancreas in comparison to standard drugs. Conclusion:The results of study illustrated that Tecomella undulata root extract possessing particular kind of phytocompounds which caused glucose homeostatic and pancreas protective potential in diabetic rats.

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Antidiabetic Attributes of Desert and Steppic Plants: A Review

Abstract: l " desert plants l " steppic plants l " antidiabetic l " oxidative stress l " reactive oxygen species (ROS) l " hypoglycemic effect

Cited by 40 publications

References 67 publications

PUFAs from Stem Bark of Alstonia boonei Synergistically Modulates Diabetic, Hepatic and Androgenic Damage by Low Expression of COX-2 and iNOS in Rats

PUFAs from Stem Bark of Alstonia boonei Synergistically Modulates Diabetic, Hepatic and Androgenic Damage by Low Expression of COX-2 and iNOS in Rats

Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes

Glucose Homeostatic and Pancreas Protective Potential of Tecomella Undulata Root Extract in Streptozotocin Induced Diabetic Rats .

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