Antidiabetic, antioxidant, and TNF-α lowering properties of extract of the traditionally used plant<i>Ixeris gracilis</i>in alloxan-induced diabetic mice

Syiem, Donkupar; Warjri, Phibangipan

doi:10.3109/13880209.2014.924151

Cited by 6 publications

(6 citation statements)

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“…DC.] contributes to the antioxidative and antidiabetic potential of plants extracts (Syiem and Warjri 2015). In this study, compared with vehicle-treated ZDF (fa/fa) rats, FJG treatment resulted in the recovery of the decreased levels of SOD and CAT activity accompanied with the inhibition of MDA.…”

Section: Discussionmentioning

confidence: 99%

Fuzhu jiangtang granules combined with metformin reduces insulin resistance in skeletal muscle of diabetic rats via PI3K/Akt signaling

Cao¹,

Sun

2019

Pharmaceutical Biology

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Context: Fuzhu Jiangtang Granules (FJG) are a traditional Chinese used in the treatment of diabetes mellitus. However, the antidiabetic mechanism of FJG is not clear.Objective: This study evaluates and determines the antidiabetic mechanism of FJG using a Zucker diabetic fatty (ZDF) rat model.Materials and methods: ZDF (fa/fa) rats were divided into four groups (n = 6): diabetes mellitus (DM), metformin (Met, 0.134 g/kg b.w./day), FJG (0.64 g/kg b.w./day), and combination (Com, 0.134 g/kg b.w./day of Met and 0.64 g/kg b.w./day of FJG). Six ZDF (fa/+) rats served as a normal control. After 6 weeks, biochemical parameters gene and protein expression were detected.Results: The FBG, bodyweight, triglyceride (TG), total cholesterol (TC), free fatty acid (FFA), insulin levels, and HOMA-IR were lower in the FJG than in the DM group (p < 0.05, p < 0.01). In an oral glucose tolerance test, the AUC in the FJG group was significantly lower (p < 0.01). The levels of superoxide dismutase and catalase were higher in the FJG than in the DM group (p < 0.01); the malondialdehyde content and TNF-α were significantly decreased in the FJG group (p < 0.01). FJG increased the mRNA expression of IR and GLUT4 significantly (p < 0.05, p < 0.01). The protein levels of IR, p-IRS1 tyr989, m-PI3Kp85, p-Akt and GLUT4 were increased in the FJG (p < 0.05, p < 0.01), but the protein levels of p-IRS1 ser1101/612/307 were significantly decreased in the JG group (p < 0.01).Discussion and conclusions: The antidiabetic mechanism of FJG may be related to regulation of the insulin-signaling pathway in skeletal muscle. These aspects require further research.

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Section: Discussionmentioning

confidence: 99%

Fuzhu jiangtang granules combined with metformin reduces insulin resistance in skeletal muscle of diabetic rats via PI3K/Akt signaling

Cao¹,

Sun

2019

Pharmaceutical Biology

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“…Stebbins (Asteraceae), traditionally used by local communities of Meghalaya in India, is listed as plant with antidiabetic potential. Administration of methanolic extract (250 mg/kg) for 12 days to alloxan-induced diabetic mice improved glucose tolerance, glycemic control, and activities of GPx and SOD in the liver, kidney, and brain [43]. Trigonella foenum graecum L. (fenugreek) is being used as folk medicine for diabetes treatment and several studies have demonstrated that fenugreek seed extract, mucilage of seeds and leaves have hypoglycemic effect in experimental diabetic animals and in humans [44,45].…”

Section: Plants In the Service Of Alleviation Of Diabetic Complicationsmentioning

confidence: 99%

The Influence of Plant Extracts and Phytoconstituents on Antioxidant Enzymes Activity and Gene Expression in the Prevention and Treatment of Impaired Glucose Homeostasis and Diabetes Complications

et al. 2021

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Diabetes is a complex metabolic disorder resulting either from insulin resistance or an impaired insulin secretion. Prolonged elevated blood glucose concentration, the key clinical sign of diabetes, initiates an enhancement of reactive oxygen species derived from glucose autoxidation and glycosylation of proteins. Consequently, chronic oxidative stress overwhelms cellular endogenous antioxidant defenses and leads to the acute and long-standing structural and functional changes of macromolecules resulting in impaired cellular functioning, cell death and organ dysfunction. The oxidative stress provoked chain of pathological events over time cause diabetic complications such as nephropathy, peripheral neuropathy, cardiomyopathy, retinopathy, hypertension, and liver disease. Under diabetic conditions, accompanying genome/epigenome and metabolite markers alterations may also affect glucose homeostasis, pancreatic β-cells, muscle, liver, and adipose tissue. By providing deeper genetic/epigenetic insight of direct or indirect dietary effects, nutrigenomics offers a promising opportunity to improve the quality of life of diabetic patients. Natural plant extracts, or their naturally occurring compounds, were shown to be very proficient in the prevention and treatment of different pathologies associated with oxidative stress including diabetes and its complications. Considering that food intake is one of the crucial components in diabetes’ prevalence, progression and complications, this review summarizes the effect of the major plant secondary metabolite and phytoconstituents on the antioxidant enzymes activity and gene expression under diabetic conditions.

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“…A natural extract from Centella asiatica, rich in ascorbic acid, asiatic acid, oleanolic acid, stevioside, stigmasterol and α-humulene protects diabetes tissues from stress via antioxidant and anti-inflammatory mechanisms eliciting brain reduced levels of malondialdehyde, TNF-α, IFN-γ, IL-4 or IL10 [127]. Similar outcomes have been reported for Ixeris gracilis extract used in mice with alloxan-induced diabetes [128]. Specific assessment of mitochondrial status in STZ-induced diabetes has also revealed the capacity of Malvastrum tricuspidatum extract to restore oxidative damage [129] (Tables 1 and 2, and Figure 1).…”

Section: Natural Compounds and Central Complications In Dmmentioning

confidence: 81%

Review of the Effect of Natural Compounds and Extracts on Neurodegeneration in Animal Models of Diabetes Mellitus

Infante-Garcia

García-Alloza

2019

IJMS

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Diabetes mellitus is a chronic metabolic disease with a high prevalence in the Western population. It is characterized by pancreas failure to produce insulin, which involves high blood glucose levels. The two main forms of diabetes are type 1 and type 2 diabetes, which correspond with >85% of the cases. Diabetes shows several associated alterations including vascular dysfunction, neuropathies as well as central complications. Brain alterations in diabetes are widely studied; however, the mechanisms implicated have not been completely elucidated. Diabetic brain shows a wide profile of micro and macrostructural changes, such as neurovascular deterioration or neuroinflammation leading to neurodegeneration and progressive cognition dysfunction. Natural compounds (single isolated compounds and/or natural extracts) have been widely assessed in metabolic disorders and many of them have also shown antioxidant, antiinflamatory and neuroprotective properties at central level. This work reviews natural compounds with brain neuroprotective activities, taking into account several therapeutic targets: Inflammation and oxidative stress, vascular damage, neuronal loss or cognitive impairment. Altogether, a wide range of natural extracts and compounds contribute to limit neurodegeneration and cognitive dysfunction under diabetic state. Therefore, they could broaden therapeutic alternatives to reduce or slow down complications associated with diabetes at central level.

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Antidiabetic, antioxidant, and TNF-α lowering properties of extract of the traditionally used plantIxeris gracilisin alloxan-induced diabetic mice

Abstract: The study supports the inclusion of Ixeris gracilis in the list of plants with antidiabetic potential.

Cited by 6 publications

References 56 publications

Fuzhu jiangtang granules combined with metformin reduces insulin resistance in skeletal muscle of diabetic rats via PI3K/Akt signaling

Fuzhu jiangtang granules combined with metformin reduces insulin resistance in skeletal muscle of diabetic rats via PI3K/Akt signaling

The Influence of Plant Extracts and Phytoconstituents on Antioxidant Enzymes Activity and Gene Expression in the Prevention and Treatment of Impaired Glucose Homeostasis and Diabetes Complications

Review of the Effect of Natural Compounds and Extracts on Neurodegeneration in Animal Models of Diabetes Mellitus

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