Antidiabetic, Antioxidant and Antihyperlipidemic Status of Heliotropium zeylanicum Extract on Streptozotocin-Induced Diabetes in Rats

Kandasamy, Murugesh; Yeligar, Veerendra C.; Dash, Deepak Kumar; Sengupta, Pinaki; Maiti, B. R.; Maity, Tapan K.

doi:10.1248/bpb.29.2202

Cited by 28 publications

(14 citation statements)

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“…Heliotropium bacciferum is a potent source of various phytochemicals and reported significant Diphenyl picryl hydrazyl (DPPH) radical scavenging activities [10]. It is a wealthy source of pyrrolizidine alkaloids, which have antimicrobial, antihyperlipidemic, antidiabetic, and antitumor properties [11]. Previously reported study revealed that the aerial parts of Heliotropium bacciferum have significant antibacterial and antifungal effects.…”

Section: Introductionmentioning

confidence: 99%

In VitroAntimicrobial Bioassays, DPPH Radical Scavenging Activity, and FTIR Spectroscopy Analysis ofHeliotropium bacciferum

Ahmad

AbdEl-Salam

Ullah³

2016

BioMed Research International

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The present study deals with the antimicrobial, antioxidant, and functional group analysis of Heliotropium bacciferum extracts. Disc diffusion susceptibility method was followed for antimicrobial assessment. Noteworthy antimicrobial activities were recorded by various plant extracts against antibiotic resistant microorganisms. Plant flower extracts antioxidant activity was investigated against 2, 2-diphenyl-1-picryl hydrazyl radical by ultraviolet spectrophotometer (517 nm). Plant extracts displayed noteworthy radical scavenging activities at all concentrations (25–225 μg/mL). Notable activities were recorded by crude, chloroform and ethyl acetate extracts up to 88.27% at 225 μg/mL concentration. Compounds functional groups were examined by Fourier transform infrared spectroscopic studies. Alkanes, alkenes, alkyl halides, amines, carboxylic acids, amides, esters, alcohols, phenols, nitrocompounds, and aromatic compounds were identified by FTIR analysis. Thin layer chromatography bioautography was carried out for all plant extracts. Different bands were separated by various solvent systems. The results of the current study justify the use of Heliotropium bacciferum in traditional remedial herbal medicines.

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Section: Introductionmentioning

confidence: 99%

In VitroAntimicrobial Bioassays, DPPH Radical Scavenging Activity, and FTIR Spectroscopy Analysis ofHeliotropium bacciferum

Ahmad

AbdEl-Salam

Ullah³

2016

BioMed Research International

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“…Heliotropium zeylanicum Burm. f. também mostrou diminuição de triacilglicerol e colesterol em ratos com diabetes induzida por estreptozocina (Murugest et al, 2006), além de Helicteres isora L. que reduziu triacilglicerol em camundongos db/db, e, em animais normais e em hamster tratados com dieta rica em gordura que também diminuiu triacilglicerol, colesterol total, LDL, e VLDL e aumentou HDL (Chakrabarti et al, 2002).…”

Section: Atividade Nas Complicações Diabéticasunclassified

Efeitos antidiabéticos de plantas medicinais

Dornas¹,

Oliveira²,

Dôres³

et al. 2009

Rev. bras. farmacogn.

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RESUMO:Diabetes mellitus (DM) é uma doença metabólica crônica caracterizada por hipeglicemia que tem impacto significante em seus pacientes. Sua incidência está crescendo rapidamente conduzindo para aumento no custo dos cuidados da doença e de suas complicações. O tratamento envolve, além de controle dietético e atividade física, o uso de fármacos que ocasionam efeitos colaterais para atingir ações farmacológicas desejadas. Entretanto, produtos de plantas são, freqüentemente, considerados menos tóxicos e com menos efeitos colaterais que drogas sintéticas e amplamente utilizadas pela população. Nesse trabalho várias espécies de plantas utilizadas experimentalmente ou na medicina popular, agindo de diferentes formas de modo a controlar glicemia e/ou inibir sintomas e complicações características da diabetes serão revisadas para avaliação de seus supostos efeitos terapêuticos.Unitermos: Diabetes, glicose, hipoglicemia, colesterol, estresse oxidativo.ABSTRACT: "Antidiabetic effects of the medicinal plants". Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemy that has a significant impact for their patients. Its incidence is raising leading to an increase in the cost of the cares of the disease and of its complications. The treatment involves, besides dietary control and physical activity, the use of drugs that cause side effects to reach wanted pharmacological actions. However, products of plants are, frequently, considered less poisonous and with fewer side effects than synthetic drugs and widely used by the population. In this paper, several species of plants, used experimentally or in the popular medicine, acting by different ways to control glycemia and/or to inhibit symptoms and characteristic complications of the diabetes, they will be reviewed for evaluation of their supposed therapeutic effects.

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“…1 Insulin resistance, a prediabetic state of resistance towards the effects of insulin on its target tissues mainly in muscle, liver, and adipose tissue, is a central pathogenic feature of diabetes. 2 Currently, PPARγ agonists are used as insulin sensitizers in the treatment of diabetes.…”

Section: Introductionmentioning

confidence: 99%

Effect of Fractions of Alcoholic Extract of Moringa oleifera Lam. Bark on Dexamethasone induced Insulin Resistance in Rats

Sholapur¹,

Patil²

2017

JYP

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Objective: Alcoholic extract of the bark of Moringa oleifera Lam. (MO), (Moringaceae), has been experimentally evaluated previously for its insulin sensitizing potentials. In the quest to explore the possibility of the class of phytochemical(s) responsible for this experimental claim, the alcoholic extract was fractionated and evaluated for insulin sensitizing effect in rat model for insulin resistance. Methods: Alcoholic extract of MO was fractionated into, non-polar [petroleum ether (PEF)], moderately non-polar [ethyl acetate (EAF)] and polar [aqueous (AQF)] fractions. The fractions obtained were investigated for their insulin sensitizing properties in dexamethasone induced insulin resistance in rats. The bioactive fraction was analysed by spectroscopy for further characterization of phytochemical(s) present. Results: Acute treatment for 4 h with dexamethasone (1 mg/kg i.p.) in rats led to the development of impaired oral glucose tolerance. Treatment with pioglitazone and EAF abolished dexamethasone induced oral glucose intolerance (OGT). Dexamethasone (1 mg/kg s.c., once daily for 11 d) administration led to the development of insulin resistance, characterised by fasting hyperglycemia, hyperinsulinemia, hypertriglyceridemia, impaired OGT and increased HOMA IR index. Treatments with EAF (140 mg/kg p.o.) and pioglitazone [PIO (10 mg/kg p.o.)] significantly prevented dexamethasone induced metabolic changes. Similarly, treatment with AQF (95 mg/kg p.o.) also significantly prevented metabolic changes due to dexamethasone except impaired OGT. In contrast PEF (15 mg/kg p.o.) failed to prevent these metabolic changes except hypertriglyceridemia. Conclusion: The present study reveals that triterpenoid and the polyphenols (procyanidin) class of phytochemicals detected in EAF of alcoholic extract of MO bark may be responsible for the prevention of dexamethasoneinduced insulin resistance in rats.Key words: Dexamethasone, Insulin resistance, Moringa oleifera, Oral glucose tolerance test, Serum triglyceride. Key message: This is the first report which confirms and speculates the presence of polyphenols and triterpenoids respectively in EAF of MO which may be responsible for preventing the development of insulin resistance in rat model.

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Antidiabetic, Antioxidant and Antihyperlipidemic Status of Heliotropium zeylanicum Extract on Streptozotocin-Induced Diabetes in Rats

Cited by 28 publications

References 22 publications

In VitroAntimicrobial Bioassays, DPPH Radical Scavenging Activity, and FTIR Spectroscopy Analysis ofHeliotropium bacciferum

In VitroAntimicrobial Bioassays, DPPH Radical Scavenging Activity, and FTIR Spectroscopy Analysis ofHeliotropium bacciferum

Efeitos antidiabéticos de plantas medicinais

Effect of Fractions of Alcoholic Extract of Moringa oleifera Lam. Bark on Dexamethasone induced Insulin Resistance in Rats

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