Antidiabetic, antihyperlipidemic and anti-inflammatory effects of tilianin in streptozotocin-nicotinamide diabetic rats

García-Díaz, Jorge Alberto; Navarrete‐Vázquez, Gabriel; García‐Jiménez, Sara; Hidalgo-Figueroa, Sergio; Almanza-Perez, Julio César; Alarcón-Aguilar, Francisco Javier; Gómez-Zamudio, Jaime; Crúz, Miguel A.; Ibarra-Barajas, Maximiliano; Estrada-Soto, Samuel

doi:10.1016/j.biopha.2016.07.023

Cited by 40 publications

(24 citation statements)

References 34 publications

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“…D. moldavica is mainly used for the treatment of a variety of cardiovascular diseases (Guo et al, 2015;Jia et al, 2017;Tan et al, 2017;Shen et al, 2019). Modern pharmacological studies have illustrated that the active ingredients in D. moldavica displayed the ability to prevent or treat neurodegenerative disorders and inflammatory disorders (García-Díaz et al, 2016;Liu et al, 2018), and suppressed the growth and proliferation of various types of cancer cells (Sato et al, 2015;Chakrabarti and Ray, 2016). Tilianin is the major effective component of the total flavonoid extract from D. moldavica (Zeng et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways

et al. 2020

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Tilianin Regulates Tumor Immunosuppressive Microenvironment these results showed that tilianin treatment increased cytotoxicity as well as the apoptotic population of FaDu cells in a dose-dependent manner. Furthermore, tilianin treatment decreased the level of anti-apoptotic markers Bcl-2 and Bcl-xL, increased the level of apoptotic factors Bad and Bax, and stimulated cytochrome c release, caspase-3 and poly ADP ribose polymerase (PARP) activation in FaDu cells. Furthermore, our findings indicated that tilianin treatment activated TLR4/p38/JNK/NF-κB signaling pathways and increased the release of inflammatory cytokines. This promoted the maturation of DCs to enhance immune system function in the tumor microenvironment. Moreover, the effects of tilianin on immune system function were abolished by TLR4 siRNA and p65 siRNA. In conclusion, these findings suggested that tilianin may be of immunotherapeutic value for inhibiting human pharyngeal squamous cell carcinoma.

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Section: Introductionmentioning

confidence: 99%

Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways

et al. 2020

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“…In Uyghur folk medicine, granules of dried DML, called Badiranji Buya Keli, have been used clinically for a few hundred years to treat coronary heart disease, blood pressure, angina, neuralgia, and atherosclerosis [ 16 , 17 ]. Commonly known as XinJiang in China, DML contains a potent antioxidant flavonoid component, tilianin (acacetin 7-glucoside, molecular formula: C 22 H 22 O 10 , molecular weight: 446.4, Fig 1A ), which is used to prevent and treat hypertension and heart failure [ 12 , 18 ]. Specifically, tilianin isolated from this medicinal herb has been shown to prevent MIRI in rats [ 19 , 20 ] by conferring cardioprotection [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway

et al. 2018

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Our previous research demonstrated that tilianin protects the myocardium in a myocardial ischemia reperfusion injury (MIRI) rat model and has prominent pharmacological potential as a cardiovascular drug. Our study aimed to investigate the molecular signaling implicated in the improvement of myocardial survival induced by tilianin, a flavonoid antioxidant. Tilianin (2.5, 5, and 10 mg/kg/d) or saline was orally administered to rats for 14 days. On the 15th day, ischemia was induced by ligating the left anterior descending artery for 45 min, followed by 4 h of reperfusion. The levels of MIRI-induced serum myocardial enzymes and cardiomyocyte apoptosis as well as infarct size were examined to assess the cardioprotective effects. Cardiac tissues were collected for western blot analyses to determine the protein expression of anti-apoptotic signaling molecules. In MIRI-treated rats, our results revealed that pre-administration of high dose-tilianin the reduced release of LDH, MDA, and CK-MB and increased the plasma SOD level, and significantly attenuated the infarct size. Western blot analysis showed that a remarkable rise in expression of Bcl-2 and XIAP, and decline in expression of Bax, Smac/Diablo, HtrA2/Omi, cleaved caspase-3, caspase-7 and caspase-9 was observed in the myocardium. The apoptosis index of cardiomyocytes further supports the cardioprotective effect of tilianin. Additionally, compared with the MIRI model group, pretreatment with high dose-tilianin group upregulated phosphorylated Akt and PI3K. In contrast, using the PI3K inhibitor LY294002 to block Akt activation effectively inhibited the protective effects of tilianin against MIRI. Tilianin pretreatment was beneficial for activating the PI3K/Akt signaling pathway and inhibiting myocardial apoptosis.

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“…Flavonoids are also potent inhibitors of cell proliferation, angiogenesis, antithromboticity, infectious properties of the viruses [24]. Flavonoids are benzo-gamma pyrone derivatives of plant origin, which activate signalling metabolism and insulin sensitising in hepatic cells and adipose tissue leads to exert anti diabetic activity [25].…”

Section: Quantitative Estimation Of Flavonoidsmentioning

confidence: 99%

A Quantitative Estimation of Phytochemicals, Anti-Diabetic and Anti-Oxidant Activities of Crude Extracts of Sphagneticola trilobata (L.) and Adathoda vasica Linn

Kurapati¹,

Pallapatti²,

Sunita³

et al. 2018

JNPR

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Due to therapeutic efficacy, Sphagneticola trilobata (roots), and Adathoda vasica (whole plant) were selected to explore anti-diabetic and anti-oxidant activities of their crude plant extracts. The plant samples were extracted with low to high polar solvents viz. n-hexane, ethyl acetate, methanol and water. Further crude extracts were screened for the presence of phytochemicals such as alkaloids, flavonoids, phenols etc. The quantitative estimation of phenols, flavonoids, alkaloids was performed by spectrophotometric approach. The evaluation of anti-oxidant activity of Sphagneticola trilobata was determined by DPPH method and ABTS method was applied to access the antioxidant activity of Adathoda vasica. The antidiabetic activity of crude extracts of Sphagneticola trilobata and Adathoda vasica was determined along with Brassica oleraceae by applying in vitro α-amylase inhibition method. The methanolic extract of Sphagneticola trilobata was significantly showed DPPH IC50 inhibition at 20 µg/mL, and in vitro α-amylase inhibition IC50 at 50 µg/mL. In Adathoda vasica methanol extract showed ABTS inhibition IC50 at 30 µg/mL, and in vitro α-amylase inhibition of IC50 at 25 µg/mL. It is concluded that methanolic extract of Sphagneticola trilobata can be potential source of anti-oxidant and methanolic extract of Adathoda vasica proven as good anti-diabetic agent.

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Antidiabetic, antihyperlipidemic and anti-inflammatory effects of tilianin in streptozotocin-nicotinamide diabetic rats

Cited by 40 publications

References 34 publications

Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways

Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways

Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway

A Quantitative Estimation of Phytochemicals, Anti-Diabetic and Anti-Oxidant Activities of Crude Extracts of Sphagneticola trilobata (L.) and Adathoda vasica Linn

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