Antidiabetic and Oxidative Stress Ameliorative Potential of
Ethanolic Extract of Pedicularis longiflora Rudolph

Yatoo, Mohd Iqbal; Dimri, Umesh; Gopalakris, Arumugam; Saminathan, Mani; Dhama, Kuldeep; Karikalan, M.; Saxena, Archana; Gopinath, D. M.; Husain, Shahid

doi:10.3923/ijp.2016.177.187

Cited by 12 publications

(10 citation statements)

References 36 publications

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“…Hence, oxidative stress plays a vital role in the development of diabetes complications such as microvascular and cardiovascular [39]. The metabolic irregularities of diabetes cause mitochondrial superoxide overproduction, which is the main linker of diabetes tissue damage, insulin resistance, β-cell dysfunction, and impaired glucose tolerance [40]. The usage of medicinal herbs in the management of diabetes and oxidative stress is well known, and these herbs contain bioactive constituents such as flavonoids, polyphenols, alkaloids, terpenoids, carotenoids, vitamins, and numerous other phytochemicals, which can act as antidiabetics and/or antioxidants/radical scavengers [41].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Alpha-glucosidase and Alpha-amylase Inhibitory Activities, Molecular Docking and Antioxidant Capacities of Salvia Aurita Constituents

Etsassala¹,

Badmus²,

Marnewick³

et al. 2020

Preprint

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Diabetes mellitus (DM) is one of the most dangerous metabolic diseases with high rate of mortality worldwide. It is well known that insulin resistance and deficiency in insulin production from pancreatic β-cells are the main characteristic of DM. Due to the detrimental side effects of the current treatment, there is a considerable need to develop new effective antidiabetic drugs, especially alpha-glucosidase and alpha-amylase inhibitors with lesser adverse effects. These inhibitors are known to be directly involved in the delay of carbohydrate digestion, resulting in a reduction of glucose absorption rate and consequently reduce the post-prandial raise of plasma glucose, which can reduce the risk of long-term diabetes complications. Hence, natural products are well-known sources for the discovery of new scaffold for drugs discovery, including new antidiabetic drugs. The phytochemical investigation of Salvia aurita collected from Hogobach pass, Eastern Cape, South Africa (SA), yielded four known abietane diterpenes namely carnosol (1), rosmanol (2), 7-methoxyrosmanol (3), 12-methoxycarnosic acid (4) and one flavonoid named 4,7-dimethylapigenin (5). Structural characterization of these isolated compounds was conducted using 1 and 2D NMR, in comparison with reported spectroscopic data. These compounds are reported for the first time from S. aurita. The biological evaluation of the isolated compound against alpha-glucosidase exhibited strong inhibitory activities for 3 and 2 with IC50 values of 4.2 ± 0.7 and 16.4 ± 1.1 µg/mL respectively, while 4 and 1 demonstrated strong alpha-amylase inhibitory activity amongst the isolated compounds with IC50 of 16.2 ± 0.3 and 19.8 ± 1.4 µg/mL. Molecular docking analysis confirms strong inhibitory activity of 3 against alpha-glucosidase. Additionally, excellent antioxidant capacities were displayed by 2, 1 and 3 respectively as ORAC (25789.9 ± 10.5; 23961.8 ± 14.1; 23939.3 ± 2.4) µM TE/g; 1 and 2 as FRAP (3917.8 ± 2.1; 1522.3 ± 0.9) µM AAE/g; 5 and 2 as TEAC (3190.4 ± 2.8; 2055.0 ± 2.6) µM TE/g. The methanolic extract of S. aurita is a rich source of abietane diterpenes with excellent antioxidant and anti-diabetic activities that can be useful to modulate oxidative stress, and might possibly be excellent candidates for the management of diabetes. This is the first scientific report on the phytochemical isolation and biological evaluation of alpha-glucosidase and alpha-amylase inhibitory activities of Salvia aurita.

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Section: Antioxidant Activitymentioning

confidence: 99%

Alpha-glucosidase and Alpha-amylase Inhibitory Activities, Molecular Docking and Antioxidant Capacities of Salvia Aurita Constituents

Etsassala¹,

Badmus²,

Marnewick³

et al. 2020

Preprint

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“…They are distributed in Europe especially in the mountainous areas of the Mediterranean Basin and of Northern Asia and America ( Figure 2). The highest biodiversity is present in Europe with about 70 species, India with about 83 species and China with about 350 species of which 271 are endemic [6][7][8]. Indeed, in North America the present species are 36 with two endemisms [9].…”

Section: Distribution and Habitatmentioning

confidence: 99%

Pedicularis L. Genus: Systematics, Botany, Phytochemistry, Chemotaxonomy, Ethnopharmacology and Other

Frezza

Venditti

Toniolo

et al. 2019

Preprint

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In this review, the relevance of plants belonging to the Pedicularis L. genus was explored from different points of view. Particular emphasys was given especially to the phytochemistry and the ethnopharmacology of the genus since several classes of natural compounds have been evidenced within it and several Pedicularis species are well known to be employed in the traditional medicine of many Asian countries. Nevertheless, some important conclusions on the chemotaxonomic and chemosystematic aspects of the genus were also provided for the first time. This work represents the first total comprehensive review on the genus Pedicularis.

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“…The two plants have been proven to have antiviral and antibacterial characteristics [ 7 ]. Plant extracts of different species have also been tested to have anti-diabetic potential, including Cordia dichotoma fruits [ 8 ] and Pedicularis longiflora Rudolph , which additionally showed antioxidant properties [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and hypolipidemic effects of two mangrove plants in a streptozotocin-induced animal model of diabetes

Zeid¹,

Jaghthmi²

2020

J Adv Vet Anim Res

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Objective: This study aims at evaluating the anti-diabetic, hypolipidemic, and pancreatic histopathological changes of Rhizophora mucronata and Avicennia marina . Materials and Methods: The experimental rats were divided into eight groups ( n = 15 each). Streptozotocin was used to induce diabetes. Daily oral administration of an aqueous extract from the leaves of R. mucronata and A. marina at 400 mg/kg BW, and a mixture of the two extracts for 6 weeks was assessed. The measurements of serum glucose, insulin, and lipid profile were carried out. Pancreatic specimens were collected from all groups and processed for pathological studies. Results: The study revealed that the plant extracts restored the levels of diabetic markers and lipid profiles of diabetic rats, with no significant changes in non-diabetic ones. The extract of R. mucronata exhibited more promising anti-diabetic and hypolipidemic effects than A. marina singly or combined. Conclusion: Leaf extracts from R. mucronata , singly or combined, and A. marina , induced a potent anti-diabetic and hypolipidemic potential in diabetic rats.

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Antidiabetic and Oxidative Stress Ameliorative Potential of Ethanolic Extract of Pedicularis longiflora Rudolph

Cited by 12 publications

References 36 publications

Alpha-glucosidase and Alpha-amylase Inhibitory Activities, Molecular Docking and Antioxidant Capacities of Salvia Aurita Constituents

Alpha-glucosidase and Alpha-amylase Inhibitory Activities, Molecular Docking and Antioxidant Capacities of Salvia Aurita Constituents

Pedicularis L. Genus: Systematics, Botany, Phytochemistry, Chemotaxonomy, Ethnopharmacology and Other

Hypoglycemic and hypolipidemic effects of two mangrove plants in a streptozotocin-induced animal model of diabetes

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