Antidiabetic and hypolipidaemic effects of few common plants extract in Type 2 diabetic patients at Bengal

The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature

“…The reviewed studies involved a total of 1111 participants with ages ranging from 10 to 80 years old with eight clinical trials limiting participants to ≥40 years old [38, 61, 66, 68–70, 72, 75]. Only three clinical trials included 100 or more participants [65, 66, 82].…”

“…From the 24 studies identified only eight included a placebo [66, 68, 70, 75–77, 81, 82]. Five of the included trials adopted a two-arm parallel design [62, 63, 65, 67, 80], while four used a cross-over design with one being described in three different papers that reported on two different sets of outcomes [70, 75, 77].…”

“…Six of the identified trials on metabolic conditions were randomized clinical trials with placebo controls [66, 68, 70, 74, 75]. In addition, eight studies were of 2–5 weeks duration [38, 63, 64, 70, 73–75], three were of 6–8 weeks [61, 62, 68], and six were of 12-13 weeks [65–67, 69, 71, 72].…”

“…In addition, eight studies were of 2–5 weeks duration [38, 63, 64, 70, 73–75], three were of 6–8 weeks [61, 62, 68], and six were of 12-13 weeks [65–67, 69, 71, 72]. When the duration of the tulsi intervention was increased from 4-5 weeks [38, 70] to 12-13 weeks there was a more dramatic reduction in fasting blood glucose (FBG) and postprandial glucose (PPG) compared to controls [66, 67].…”

“…In comparable trials with longer durations, FBG and PPG improved by 1.2–2.2 and 1.5–6.0 folds, respectively, while HbA1c improved 1.5 and 3.2 fold after 12-13 weeks [66, 67]. Similarly, lipid profile was improved significantly in MetS and diabetes participants in three clinical trials [38, 66, 68] with a separate clinical trial reporting significant improvement in lipid profile in obese participants [62] and a further study reporting improved lipid levels in healthy subjects [74]. …”