Antidiabetic and antioxidant effect of magnetic and noble metal nanoparticles of Clitoria ternatea

Sa, Nishigandha; Tejaswani, P.; Pradhan, Sweta Priyadarshini; Alkhayer, Khider Ali; Behera, Anindita; Sahu, Pratap Kumar

doi:10.1016/j.jddst.2023.104521

Cited by 2 publications

(2 citation statements)

References 61 publications

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“…For example, it has been reported that LaNPs synthesized with the aqueous extract from Moringa oleifera can scavenge 61.0 and 78.5% of DPPH radicals at 100 and 200 µg/mL, respectively [36]. Using other experimental models, the capacity of LaNPs to prevent the generation of free radicals has been related to the electronic configuration of their 4f shielded electrons [37]. For Sm-based nanomaterials, however, biomedical evidence on their antioxidant activity is scarce.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Lanthanide-Doped ZnO Nanoparticles: Unraveling Their Role in Cytotoxicity, Antioxidant Capacity, and Nanotoxicology

Mejía-Méndez,

Navarro-López,

Sanchez-Martinez

et al. 2024

Antioxidants

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This study used a sonochemical synthesis method to prepare (La, Sm)-doped ZnO nanoparticles (NPs). The effect of incorporating these lanthanide elements on the structural, optical, and morphological properties of ZnO-NPs was analyzed. The cytotoxicity and the reactive oxygen species (ROS) generation capacity of ZnO-NPs were evaluated against breast (MCF7) and colon (HT29) cancer cell lines. Their antioxidant activity was analyzed using a DPPH assay, and their toxicity towards Artemia salina nauplii was also evaluated. The results revealed that treatment with NPs resulted in the death of 10.559–42.546% and 18.230–38.643% of MCF7 and HT29 cells, respectively. This effect was attributed to the ability of NPs to downregulate ROS formation within the two cell lines in a dose-dependent manner. In the DPPH assay, treatment with (La, Sm)-doped ZnO-NPs inhibited the generation of free radicals at IC50 values ranging from 3.898 to 126.948 μg/mL. Against A. salina nauplii, the synthesized NPs did not cause death nor induce morphological changes at the tested concentrations. A series of machine learning (ML) models were used to predict the biological performance of (La, Sm)-doped ZnO-NPs. Among the designed ML models, the gradient boosting model resulted in the greatest mean absolute error (MAE) (MAE 9.027, R2 = 0.86). The data generated in this work provide innovative insights into the influence of La and Sm on the structural arrangement and chemical features of ZnO-NPs, together with their cytotoxicity, antioxidant activity, and in vivo toxicity.

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Section: Antioxidant Activitymentioning

confidence: 99%

Lanthanide-Doped ZnO Nanoparticles: Unraveling Their Role in Cytotoxicity, Antioxidant Capacity, and Nanotoxicology

Mejía-Méndez,

Navarro-López,

Sanchez-Martinez

et al. 2024

Antioxidants

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“…14 Additionally, they are extensively used in biomedicine and environmental applications due to their favorable optical, chemical, mechanical, electrical, and magnetic characteristics. 15–18 These NPs can be produced using a variety of physical, chemical, and biological methods. 19 Biological methods are regarded as a green route for the synthesis of metal and metal oxide NPs without requiring harmful chemicals and reagents.…”

Section: Introductionmentioning

confidence: 99%

Carbohydrate polymer-supported metal and metal oxide nanoparticles for constructing electrochemical sensors

Zahran

2024

Mater. Adv.

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Antidiabetic and antioxidant effect of magnetic and noble metal nanoparticles of Clitoria ternatea

Cited by 2 publications

References 61 publications

Lanthanide-Doped ZnO Nanoparticles: Unraveling Their Role in Cytotoxicity, Antioxidant Capacity, and Nanotoxicology

Lanthanide-Doped ZnO Nanoparticles: Unraveling Their Role in Cytotoxicity, Antioxidant Capacity, and Nanotoxicology

Carbohydrate polymer-supported metal and metal oxide nanoparticles for constructing electrochemical sensors

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