Antidiabetic and antimicrobial activities of fractions and compounds isolated from &lt;i&gt;Berberis brevissima&lt;/i&gt; Jafri and &lt;i&gt;Berberis parkeriana&lt;/i&gt; Schneid

Ali, Saqib; Igoli, John O.; Clements, Carol; Semaan, Dima; Almazeb, Muhammad; Rashid, Mehboob ur; Shah, Syed Qaisar; Ferro, Valerie A.; Gray, Alexander; Khan, Muhammad Rafiullah

doi:10.3329/bjp.v8i3.13888

Cited by 11 publications

(8 citation statements)

References 15 publications

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“…Moreover, aqueous root extract of B. vulgaris shows potent and significant hypoglycemic effects in streptozotocin-induced diabetic rats, with significant increases in serum cholesterol and serum triglycerides levels [57]. B. brevissima and B. parkeriana are also have anti-diabetic activities [58].…”

Section: Anti-diabetic Activitymentioning

confidence: 99%

Phytopharmacological and ethnomedicinal uses of the Genus Berberis (Berberidaceae): A review

Khan¹,

Najeebullah²,

Ali³

et al. 2016

Trop. J. Pharm Res

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Section: Anti-diabetic Activitymentioning

confidence: 99%

Phytopharmacological and ethnomedicinal uses of the Genus Berberis (Berberidaceae): A review

Khan¹,

Najeebullah²,

Ali³

et al. 2016

Trop. J. Pharm Res

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“…Berberine is the major constituent of the Berberis spp. along with other principal isoquinoline alkaloids (Freile et al, 2003;Ali et al, 2013). Berberine was reported to be the principal antibacterial and antifungal component of the Berberis genus.…”

Section: Conclusion and Recommendationsmentioning

confidence: 99%

Phytochemical and Antimicrobial Potential of the Roots of Berberis brevissima Jafri. (Berberidaceae)

Ullah¹,

Shad²,

Ali³

2021

SJA

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B erberis is the only genus of the family Berberidaceae, in the southerly hemisphere and comprises 600 species (Bai et al., 2011; Ali et al., 2020). About 24 species are widely distributed in Pakistan's mountainous parts, including Baluchistan, Gilgit, Chitral, Hazara, Murree, Swat, Dir, and Kashmir (Ali et al., 2020). The species is about 1-5 m tall, having deciduous and evergreen shrubs with yellow wood, thorny shoots, and simple leaves. Many species are distinguished for their attractive pink, violet, blue, or dark red color (Arayne et al., 2007). Various species of Berberis are generally dispersed in the temperate and semi-temperate region and are inherent of the whole range of the Himalayas Mountains and North America, Europe, Asia, and the Mediterranean regions (Knapp and Melly, 1986;Chevallier, 2011). The Spe-cies of the Berberis genus are famous for their traditional medicinal use. The evergreen shrub species with the intense pale-yellow color of shoots and roots are used for various ailments, such as rheumatism, stomach disorders diabetes, ear and eye infections, malarial fever, fever, skin disease, and jaundice in remote and rural areas (

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“…In order to identify a particular compound's location within tissues, techniques such as MALDI-TOF MS are usually employed. Compounds isolated in this way from different natural sources have consistently shown promising therapeutic potential against a range of diseases including cancer, hypertension, diabetes and infections [26]. In evaluating extracts and isolated compounds, a range of bioassays are employed to determine the potential therapeutic activity present [27].…”

Section: Impact Of Drug-delivery Systems In Natural Product Researchmentioning

confidence: 99%

Delivering Natural Products and Biotherapeutics to Improve Drug Efficacy

et al. 2017

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Due to the increasing problem of drug resistance, new and improved medicines are required. Natural products and biotherapeutics offer a vast resource for new drugs; however, challenges, including the cost and time taken for traditional drug discovery processes and the subsequent lack of investment from the pharmaceutical industry, are associated with these areas. New techniques are producing compounds with appropriate activity at a faster rate. While the formulation of these combined with drug-delivery systems offers a promising approach for expanding the drug developments available to modern medicine. Here, various classes of drug-delivery systems are described and the advantages they bring to small molecule and biotherapeutic targeting are highlighted. This is an attractive approach to the pharmaceutical industry and the rising trend in research in this area is examined in brief. New medicines are constantly being developed or repurposed, aimed at curing or preventing diseases or conditions where therapeutic product availability is lacking, or to reduce side effects, improve quality of life, reduce the burden on the cost of healthcare systems, while significantly extending patients' lives. However, drug discovery, research and development (R&D) can be an extensive process lasting over 7-10 years, with an average cost of $2.6 billion for each successful drug that reaches the market [1]. These substantial cost and time factors originate from the scientific, technical and regulatory challenges that are needed to fully understand the drug mechanisms of action and physiological interactions for complex diseases at molecular level. Achieving viable commercial success subsequently

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Antidiabetic and antimicrobial activities of fractions and compounds isolated from <i>Berberis brevissima</i> Jafri and <i>Berberis parkeriana</i> Schneid

Cited by 11 publications

References 15 publications

Phytopharmacological and ethnomedicinal uses of the Genus Berberis (Berberidaceae): A review

Phytopharmacological and ethnomedicinal uses of the Genus Berberis (Berberidaceae): A review

Phytochemical and Antimicrobial Potential of the Roots of Berberis brevissima Jafri. (Berberidaceae)

Delivering Natural Products and Biotherapeutics to Improve Drug Efficacy

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