Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats, role of HMG CoA: In vivo and in silico approaches

Asiatic Acid Reduces Blood Pressure by Enhancing Nitric Oxide Bioavailability with Modulation of eNOS and p47phox Expression in l‐NAME‐induced Hypertensive Rats

“…There is no report on the toxicity of AA in the animal models. Nevertheless, LD50 of AA of 42 ± 3.5 μM has been found in tumor cell lines (PPC‐1 prostate cancer cells; Gurfinkel et al ., ).The concentrations of AA used in the present study were influenced by the two recent reports of AA activity in streptozotocin‐induced diabetic rats (Ramachandran and Saravanan, ; Ramachandran et al ., ).…”

“…Asiatic acid (AA) is a triterpenoid component found in Centella asiatica. Previous studies have demonstrated that AA has antioxidant, antiinflammatory, antidiabetic, and antihyperlipidemic effects (Huang et al, 2011;Ramachandran et al, 2014). While other triterpenoid compounds have been shown to mediate a vasorelaxant effect in isolated rat thoracic aorta by enhancing NO release (Aguirre-Crespo et al, 2006) and to reduce blood pressure in L-NAME-treated rats by ameliorating oxidative stress and restoring vascular function (Fu et al, 2011), it remains unknown whether AA shows the same antihypertensive activity.…”

Proposed mechanisms of Terminalia catappa in hyperglycaemia and associated diabetic complications

“…Therefore, quercetin and ursolic acid ultimately reduce total plasma LDL cholesterol levels and thus may potentially be utilized for the prevention of diabetic nephropathy . Another triterpenoid present in T. catappa , named asiatic acid, also presented similar LDL cholesterol‐lowering activity by reducing the expression of HMG CoA reductase enzyme and subsequently decreasing increased plasma glucose, total cholesterol, triglycerides, free fatty acids, phospholipids, low‐density lipoprotein, very low density lipoprotein, atherogenic index and increasing insulin and high‐density lipoprotein in animal models of streptozotocin (STZ)‐induced diabetes, thus demonstrating antidiabetic and antihyperlipidaemic properties …”

“…[53,59] Another triterpenoid present in T. catappa, named asiatic acid, also presented similar LDL cholesterol-lowering activity by reducing the expression of HMG CoA reductase enzyme and subsequently decreasing increased plasma glucose, total cholesterol, triglycerides, free fatty acids, phospholipids, low-density lipoprotein, very low density lipoprotein, atherogenic index and increasing insulin and high-density lipoprotein in animal models of streptozotocin (STZ)induced diabetes, thus demonstrating antidiabetic and antihyperlipidaemic properties. [60] Another recent study concluded that administration of a decoction of T. catappa (containing tannins, flavonoids, saponins, b-carotene, thiocyanates, cardiac glycosides, alkaloids, cyanogenic glycosides, vitamin C, q-hydroxybenzoic acid, alkaloids, catechins, free amino acids and monosaccharides) in Wistar rats resulted in improvement in the lipid profile by preventing the oxidation of LDL, reducing elevated serum total cholesterol, triacylglycerol, VLDL cholesterol, serum LDL cholesterol levels and augmenting the production of HDL and phospholipids. HDL is associated with the destruction of oxidized LDL while phospholipids are an important constituent of bile which helps in the solubilizing of cholesterol due to their detergent action.…”

Biopharmaceutical and pharmacokinetic characterization of asiatic acid in Centella asiatica as determined by a sensitive and robust HPLC–MS method

“…Asiatic acid is a triterpenoid component found in Centella asiatica Pakdeechote et al, 2014;Ramachandran et al, 2014), which is an important herb used widely in China and gradually becomes popular in the west (Gohil et al, 2010;Kavitha et al, 2011;Orhan, 2012;Xu et al, 2013;Chen et al, 2014;Yan et al, 2014). Previous studies have demonstrated that asiatic acid could be used for wound healing, various skin conditions, inflammatory, diabetic, hyperlipidemic, and also for anti-depressant, relieving anxiety and improving cognition (Jeong, 2006;Tang et al, 2012;Xu et al, 2012;Zhang et al, 2012;Wei et al, 2013).…”