Antidiabetic and antihyperlipidemic activity of ethyl acetate:Isopropanol (1:1) fraction of Vernonia anthelmintica seeds in Streptozotocin induced diabetic rats

In vivo and in vitro studies to identify the hypoglycaemic constituents of Momordica charantia wild variant WB24

“…The in vivo hypoglycaemic activities of these fractions were then confirmed in animal experiments. In general, the dosages of plant extracts or fractions used in animal tests for hypoglycaemic activity assays are around 100-1000 mg/kg/day as reported in the literature, and animals are usually administered the sample for 21 days or more in order to demonstrate an obvious reduction in blood glucose (e.g., Fatima et al, 2010;Wang et al, 2008Wang et al, , 2010. Thus, the dosages of fraction 16 (50 mg/kg/day) and fractions 21 and 23 (100 mg/kg/day) used in this study were quite reasonable or even low, and the number of days of administration required for the animals to display reduced blood glucose were comparatively short.…”

Biologically active steroids from the aerial parts of Vernonia anthelmintica Willd

“…Vernonia anthelmintica Willd belongs to the family Compositae and has been used for curing asthma, hiccough, inflammatory swellings, sores, and itching of the eyes [1][2][3]. Members of genus Vernonia were well known for the production of sesquiterpene lactones and stigmastane-type steroids and steroidal glycosides [4][5][6][7][8].…”

Hypolipidemic potential of Lepidogrammitis drymoglossoides in high-fat diet fed mice

“…It suggests that LPL and HL are rate-limiting enzymes involved in the lipolysis of lipoprotein TG, which stores TG in adipose tissue and serves as an energy source [12,13]. AST and ALT are used to evaluate hepatic disorders induced by hyperlipidemia [14]. In our experiment, LD caused a reduction in the activities of AST and ALT, and an enhancement of the levels of LPL and HL.…”